| Gene Symbol |
NKX3-2
|
| Entrez Gene |
579
|
| Alt Symbol |
BAPX1, NKX3.2, NKX3B, SMMD
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
NK3 homeobox 2
|
| Other Description |
bagpipe homeobox protein homolog 1|homeobox protein NK-3 homolog B|homeobox protein Nkx-3.2
|
| Swissprots |
Q2M2I7 P78367
|
| Accessions |
AAB49696 AAB82784 AAC39536 EAW92714 P78367 AF009801 AAB82783 BC111926 AAI11927 BC111966 AAI11967 BC118497 AAI18498 EU446467 ABZ91996 NM_001189 NP_001180
|
| Function |
Transcriptional repressor that acts as a negative regulator of chondrocyte maturation. PLays a role in distal stomach development; required for proper antral-pyloric morphogenesis and development of antral-type epithelium. In concert with GSC, defines the structural components of the middle ear; required for tympanic ring and gonium development and in the regulation of the width of the malleus (By similarity). {ECO:0000250}.
|
| Subcellular Location |
Nucleus {ECO:0000305}.
|
| Tissue Specificity |
Expressed at highest levels in cartilage, bone (osteosarcoma) and gut (small intestine and colon), whereas moderate expression is seen in trachea and brain. Expressed in visceral mesoderm and embryonic skeleton. {ECO:0000269|PubMed:20004766}.
|