ASXL1

Gene Symbol	ASXL1
Entrez Gene	171023
Alt Symbol	BOPS, MDS
Species	Human
Gene Type	protein-coding
Description	additional sex combs like transcriptional regulator 1
Other Description	additional sex combs like 1|putative Polycomb group protein ASXL1
Swissprots	Q8IYY7 Q8IXJ9 Q9Y2I4 B2RP59 Q9UFP8 Q9H466 Q9NQF8 Q9UFJ0 Q5JWS9
Accessions	EAW76377 EAW76378 EAW76379 EAW76380 Q8IXJ9 AB023195 BAA76822 AB084280 BAD00087 AJ438952 CAD27708 AK025756 AK122923 BAG53800 AL117518 CAB55975 AL117647 CAB56029 BC033284 AAH33284 BC064984 AAH64984 BC100280 AAI00281 BC137278 AAI37279 BC137280 AAI37281 BQ064719 BU686340 BX109122 CR977683 XM_006723727 XP_006723790 XM_006723728 XP_006723791 XM_006723730 XP_006723793 XM_006723732 XP_006723795 XM_006723733 XP_006723796 XM_011528647 XP_011526949 XM_011528648 XP_011526950 XM_011528649 XP_011526951 XM_011528650 XP_011526952 XM_011528651 XP_011526953 XM_011528652 XP_011526954 NM_001164603 NP_001158075 NM_015338 NP_056153
Function	Probable Polycomb group (PcG) protein involved in transcriptional regulation mediated by ligand-bound nuclear hormone receptors, such as retinoic acid receptors (RARs) and peroxisome proliferator-activated receptor gamma (PPARG). Acts as coactivator of RARA and RXRA through association with NCOA1. Acts as corepressor through recruitment of KDM1A and CBX5 to target genes in a cell-type specific manner; the function seems to involve differential recruitment of methylated histone H3 to respective promoters. Acts as corepressor for PPARG and suppresses its adipocyte differentiation-inducing activity (By similarity). Non-catalytic component of the PR-DUB complex, a complex that specifically mediates deubiquitination of histone H2A monoubiquitinated at 'Lys-119' (H2AK119ub1). {ECO:0000250, ECO:0000269|PubMed:16606617, ECO:0000269|PubMed:20436459}.
Subcellular Location	Nucleus {ECO:0000250}.
Tissue Specificity	Widely expressed at low level. Expressed in heart, brain, skeletal muscle, placenta, pancreas, spleen, prostate, small intestine, colon, peripheral blood, leukocytes, bone marrow and fetal liver. Highly expressed in testes. {ECO:0000269|PubMed:10231032, ECO:0000269|PubMed:12657473}.

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human ASXL1 full length protein - ab153620 from Abcam Category Protein Prices $402.00 Sizes 10 µg Source Wheat germ Species Human

Human ASXL1 protein fragment - ab185833 from Abcam Category Protein Prices $442.00 Sizes 10 µg Source E. coli Species Human

ASXL1 Antibody Blocking Peptide - LS-E780 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

Recombinant Human ASXL1 Protein - H00171023-P01 from Novus Biologicals Category Protein Prices $369.00, $529.00 Sizes 10 µg, 25 µg Source Wheat Germ Species Human

ASXL1-Antibody-Center-Blocking-peptide - BP11132c from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

Human ASXL1 protein - orb180390 from Biorbyt Category Protein Prices $408.00, $595.00, $2,074.00, $2,933.00 Sizes 10 μg, 50 μg, 500 μg, 1 mg Species Human

ASXL1 - H00171023-P01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Species Human

ASXL1 - H00171023-P01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Species Human

ASXL1 fusion protein - Ag10305 from Proteintech Group Category Protein Prices $199.00 Sizes 50 μg Source E. coli -derived, PET28a Species Human

ASXL1 fusion protein - Ag10290 from Proteintech Group Category Protein Prices $199.00 Sizes 50 μg Source E. coli -derived, PGEX-4T Species Human

Recombinant Human ASXL1, His-tagged - ASXL1-9951H from Creative Biomart Category Protein Source E.coli Species Human

Recombinant Human Putative Polycomb group protein ASXL1(ASXL1) ,partial - CSB-YP809007HU CSB-EP809007HU CSB-BP809007HU CSB-MP809007HU from Cusabio Category Protein Source Yeast or E.coli or Baculovirus or Mammalian cell Species Human

Additional sex combs like 1 (ASXL1) - TP328030 from Acris Antibodies Category Protein Prices $680.00 Sizes 20 µg Source HEK293 cells Species Human

ASXL1 Peptide, Human - M34GP01069H from Creative Peptides Category Peptide Source Synthetic. Species Human

ASXL1 fusion protein - Ag25874 from Proteintech Group Category Protein Prices $199.00 Sizes 50 μg Source E. coli -derived, PGEX-4T Species Human

Human ASXL1 protein - orb391264 from Biorbyt Category Protein Prices $374.00, $901.00, $3,536.00 Sizes 10 μl (Trial size), 50 μl, 500 μl Species Human

Putative Polycomb group protein ASXL1 (ASXL1), partial, Recombinant Protein - MBS1432924 from MyBioSource Category Protein Source E Coli or Yeast or Baculovirus or Mammalian Cell Species Human

ASXL1 Recombinant Protein Antigen - NBP2-56271PEP from Novus Biologicals Category Protein Prices $199.00 Sizes 100 µl Source E.coli Species Human

Recombinant Human Putative Polycomb Group Protein ASXL1 (N-GST) - AP75871 from Signalway Antibody Category Protein Prices $349.00, $749.00, $2,489.00, $3,489.00 Sizes 10 µg, 50 µg, 500 µg, 1 mg Source E. coli Species Human

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