| Gene Symbol |
TRIM68
|
| Entrez Gene |
55128
|
| Alt Symbol |
GC109, RNF137, SS-56, SS56
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
tripartite motif containing 68
|
| Other Description |
E3 ubiquitin-protein ligase TRIM68|Ro/SSA1 related protein|SSA protein SS-56|ring finger protein 137|tripartite motif-containing protein 68
|
| Swissprots |
Q8WZ70 Q9H9C2 Q6AZZ1 Q96PF7 Q9NW18 A6NI19 B4DVK4 A8K551 B3KPM5 Q96LE5
|
| Accessions |
CAK32341 EAW68834 EAW68835 Q6AZZ1 AF360739 AAL11501 AF439153 AAL31641 AK001231 BAA91569 AK022923 BAB14309 AK056523 BAG51737 AK291166 BAF83855 AK301120 BAG62716 AK310888 AL832730 AM392750 CAL37628 AY005802 AAF91075 BC075058 AAH75058 BC109063 AAI09064 DA833140 DC402744 EU446815 ABZ92344 NM_001304496 NP_001291425 NM_018073 NP_060543
|
| Function |
Functions as a ubiquitin E3 ligase. Acts as a coactivator of androgen receptor (AR) depending on its ubiquitin ligase activity. {ECO:0000269|PubMed:18451177}.
|
| Subcellular Location |
Cytoplasm, perinuclear region. Nucleus. Note=Colocalized with AR in nucleus.
|
| Tissue Specificity |
Widely expressed. Expressed at high levels in prostate cancer cell lines. Up-regulation could be restricted to androgen-dependent cells. {ECO:0000269|PubMed:11560955, ECO:0000269|PubMed:11597395, ECO:0000269|PubMed:18451177}.
|