Gene Symbol | LIM2 |
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Entrez Gene | 3982 |
Alt Symbol | CTRCT19, MP17, MP19 |
Species | Human |
Gene Type | protein-coding |
Description | lens intrinsic membrane protein 2, 19kDa |
Other Description | MP18|MP20|lens fiber membrane intrinsic protein |
Swissprots | Q9BXD0 Q6B083 Q9HAR5 P55344 |
Accessions | AAG32328 EAW72010 EAW72011 P55344 AF340019 AAK26327 AF340020 AAK26328 BC069430 AAH69430 BC074916 AAH74916 BC074917 AAH74917 BC126139 AAI26140 BU734982 CD675859 HQ258752 ADR83503 NM_001161748 NP_001155220 NM_030657 NP_085915 |
Function | Present in the thicker 16-17 nm junctions of mammalian lens fiber cells, where it may contribute to cell junctional organization. Acts as a receptor for calmodulin. May play an important role in both lens development and cataractogenesis. |
Subcellular Location | Membrane; Multi-pass membrane protein. |
Tissue Specificity | Eye lens specific. {ECO:0000269|PubMed:12107413}. |
MP19 CRISPR/Cas9 KO Plasmid (h) - sc-409642 from Santa Cruz Biotechnology
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MP19 HDR Plasmid (h) - sc-409642-HDR from Santa Cruz Biotechnology
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MP19 Double Nickase Plasmid (h) - sc-409642-NIC from Santa Cruz Biotechnology
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MP19 Double Nickase Plasmid (h2) - sc-409642-NIC-2 from Santa Cruz Biotechnology
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MP19 CRISPR Activation Plasmid (h) - sc-409642-ACT from Santa Cruz Biotechnology
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MP19 CRISPR Activation Plasmid (h2) - sc-409642-ACT-2 from Santa Cruz Biotechnology
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MP19 Lentiviral Activation Particles (h) - sc-409642-LAC from Santa Cruz Biotechnology
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MP19 Lentiviral Activation Particles (h2) - sc-409642-LAC-2 from Santa Cruz Biotechnology
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MP19 siRNA (h) - sc-97373 from Santa Cruz Biotechnology
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MP19 shRNA Plasmid (h) - sc-97373-SH from Santa Cruz Biotechnology
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MP19 shRNA (h) Lentiviral Particles - sc-97373-V from Santa Cruz Biotechnology
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CompoZr® Knockout ZFN Kit - CKOZFN11718 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND11718 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR02537 from Sigma-Aldrich
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LIM2 siRNA (Human) - CRH2695 from Cohesion Biosciences
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shRNA set against Human LIM2 (NM_030657.3) - SHH330339 from Creative biogene
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Human LIM2 siRNA - orb263197 from Biorbyt
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LIM2 shRNA Plasmid (Human) - CHH2695 from Cohesion Biosciences
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LIM2 miRNA 3'UTR clone - MiUTR4H-TG05064 from Creative biogene
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