| Gene Symbol |
HEPACAM
|
| Entrez Gene |
220296
|
| Alt Symbol |
GlialCAM, MLC2A, MLC2B
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
hepatic and glial cell adhesion molecule
|
| Other Description |
hepatocyte cell adhesion molecule|protein hepaCAM
|
| Swissprots |
Q8N7I3 Q8ND35 Q6ZWL4 Q67IP8 Q14CZ8
|
| Accessions |
EAW67614 EAW67615 EAW67616 Q14CZ8 AK098396 BAC05297 AK122595 BAC85486 AL834419 CAD39081 AY047587 AAQ93018 BC037810 BC104831 AAI04832 BC113562 AAI13563 DA239226 XM_005271449 XP_005271506 XM_006718786 XP_006718849 XM_011542669 XP_011540971 NM_152722 NP_689935
|
| Function |
Involved in regulating cell motility and cell-matrix interactions. May inhibit cell growth through suppression of cell proliferation. {ECO:0000269|PubMed:15885354, ECO:0000269|PubMed:15917256}.
|
| Subcellular Location |
Cytoplasm {ECO:0000269|PubMed:15885354, ECO:0000269|PubMed:15917256}. Membrane; Single-pass type I membrane protein; Cytoplasmic side {ECO:0000269|PubMed:15885354, ECO:0000269|PubMed:15917256}. Note=In MCF-7 breast carcinoma and hepatic Hep 3B2.1-7 and Hep-G2 cell lines, localization of HEPACAM is cell density-dependent. In well spread cells, localized to punctate structures in the perinuclear membrane, cytoplasm, and at cell surface of protusions. In confluent cells, localized predominantly to the cytoplasmic membrane, particularly in areas of cell-cell contacts. Colocalizes with CDH1.
|
