| Gene Symbol |
POLR3G
|
| Entrez Gene |
10622
|
| Alt Symbol |
RPC32, RPC7
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
polymerase (RNA) III (DNA directed) polypeptide G (32kD)
|
| Other Description |
DNA-directed RNA polymerase III 32 kDa polypeptide|DNA-directed RNA polymerase III subunit G|DNA-directed RNA polymerase III subunit RPC7|RNA polymerase III 32 kDa subunit|RNA polymerase III subunit C7
|
| Swissprots |
A8MTH0 O15318
|
| Accessions |
CCQ43359 EAW95980 EAW95981 EAW95982 O15318 AK025490 AK295434 BAG58376 BC140282 AAI40283 BC141649 AAI41650 BM788728 BP348952 CD657312 U93868 AAB63676 XM_005248404 XP_005248461 XM_006714519 XP_006714582 XM_006714520 XP_006714583 XM_011543100 XP_011541402 XM_011543101 XP_011541403 XM_011543102 XP_011541404 XM_011543103 XP_011541405 XM_011543104 XP_011541406 XM_011543105 XP_011541407 XM_011543106 XP_011541408 NM_006467 NP_006458
|
| Function |
DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Specific peripheric component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and tRNAs. May direct with other members of the RPC3/POLR3C-RPC6/POLR3F- RPC7/POLR3G subcomplex RNA Pol III binding to the TFIIIB-DNA complex via the interactions between TFIIIB and POLR3F. May be involved either in the recruitment and stabilization of the subcomplex within RNA polymerase III, or in stimulating catalytic functions of other subunits during initiation. Plays a key role in sensing and limiting infection by intracellular bacteria and DNA viruses. Acts as nuclear and cytosolic DNA sensor involved in innate immune response. Can sense non-self dsDNA that serves as template for transcription into dsRNA. The non-self RNA polymerase III transcripts, such as Epstein-Barr virus-encoded RNAs (EBERs) induce type I interferon and NF- Kappa-B through the RIG-
|
| Subcellular Location |
Nucleus {ECO:0000250}.
|
| Top Pathways |
Cytosolic DNA-sensing pathway, Epstein-Barr virus infection, Purine metabolism, RNA polymerase, Pyrimidine metabolism
|