POLR3G

Gene Symbol	POLR3G
Entrez Gene	10622
Alt Symbol	RPC32, RPC7
Species	Human
Gene Type	protein-coding
Description	polymerase (RNA) III (DNA directed) polypeptide G (32kD)
Other Description	DNA-directed RNA polymerase III 32 kDa polypeptide|DNA-directed RNA polymerase III subunit G|DNA-directed RNA polymerase III subunit RPC7|RNA polymerase III 32 kDa subunit|RNA polymerase III subunit C7
Swissprots	A8MTH0 O15318
Accessions	CCQ43359 EAW95980 EAW95981 EAW95982 O15318 AK025490 AK295434 BAG58376 BC140282 AAI40283 BC141649 AAI41650 BM788728 BP348952 CD657312 U93868 AAB63676 XM_005248404 XP_005248461 XM_006714519 XP_006714582 XM_006714520 XP_006714583 XM_011543100 XP_011541402 XM_011543101 XP_011541403 XM_011543102 XP_011541404 XM_011543103 XP_011541405 XM_011543104 XP_011541406 XM_011543105 XP_011541407 XM_011543106 XP_011541408 NM_006467 NP_006458
Function	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Specific peripheric component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and tRNAs. May direct with other members of the RPC3/POLR3C-RPC6/POLR3F- RPC7/POLR3G subcomplex RNA Pol III binding to the TFIIIB-DNA complex via the interactions between TFIIIB and POLR3F. May be involved either in the recruitment and stabilization of the subcomplex within RNA polymerase III, or in stimulating catalytic functions of other subunits during initiation. Plays a key role in sensing and limiting infection by intracellular bacteria and DNA viruses. Acts as nuclear and cytosolic DNA sensor involved in innate immune response. Can sense non-self dsDNA that serves as template for transcription into dsRNA. The non-self RNA polymerase III transcripts, such as Epstein-Barr virus-encoded RNAs (EBERs) induce type I interferon and NF- Kappa-B through the RIG-
Subcellular Location	Nucleus {ECO:0000250}.
Top Pathways	Cytosolic DNA-sensing pathway, Epstein-Barr virus infection, Purine metabolism, RNA polymerase, Pyrimidine metabolism

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human POLR3G protein fragment - ab161076 from Abcam Category Protein Source Wheat germ Species Human

POLR3G Antibody Blocking Peptide - LS-E4622 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

POLR3G Antibody Blocking Peptide - LS-E24583 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

Recombinant Human POLR3G Protein - H00010622-Q01 from Novus Biologicals Category Protein Prices $369.00, $529.00 Sizes 10 µg, 25 µg Source Wheat Germ Species Human

POLR3G-Antibody-C-term-Blocking-Peptide - BP16982b from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

POLR3G Blocking Peptide - abx161198 from Abbexa Category Peptide Species Human, Mouse, Rat, Monkey

POLR3G - H00010622-Q01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Species Human

POLR3G - H00010622-Q01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Species Human

POLR3G fusion protein - ag19872 from Proteintech Group Category Protein Source E. coli-derived, PET28a Species Human

POLR3G fusion protein - ag18282 from Proteintech Group Category Protein Source E. coli-derived, PGEX-4T Species Human

Recombinant Human POLR3G - POLR3G-1731H from Creative Biomart Category Protein Source Mammalian Cells Species Human

POLR3G Blocking Peptide - CBP3697 from Cohesion Biosciences Category Peptide Prices $100.00, $300.00 Sizes 1 mg, 5 mg Species Human, Mouse, Rat, Monkey

Recombinant Human DNA-directed RNA polymerase III subunit RPC7(POLR3G) - CSB-YP018349HU CSB-EP018349HU CSB-BP018349HU CSB-MP018349HU from Cusabio Category Protein Source Yeast or E.coli or Baculovirus or Mammalian cell Species Human

POLR3G Peptide, Human - M34GP12110H from Creative Peptides Category Peptide Source Synthetic. Species Human

POLR3G Recombinant Protein Antigen - NBP2-55778PEP from Novus Biologicals Category Protein Prices $199.00 Sizes 100 µl Source E.coli Species Human

DNA-directed RNA polymerase III subunit RPC7 (POLR3G), Recombinant Protein - MBS1174852 from MyBioSource Category Protein Prices $975.00, $975.00, $1,200.00, $1,200.00, $1,470.00, $1,470.00, $1,935.00, $1,935.00 Sizes 500 µg (E-Coli), 50 µg (Baculovirus), 500 µg (Yeast), 50 µg (Mammalian-Cell), 1 mg (E-Coli), 100 µg (Baculovirus), 1 mg (Yeast), 100 µg (Mammalian-Cell) Source E Coli or Yeast or Baculovirus or Mammalian Cell Species Human

POLR3G peptide - orb234572 from Biorbyt Category Peptide

Search more