Gene Symbol | Cyp24a1 |
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Entrez Gene | 13081 |
Alt Symbol | 24-OHase, CP24, Cyp24 |
Species | Mouse |
Gene Type | protein-coding |
Description | cytochrome P450, family 24, subfamily a, polypeptide 1 |
Other Description | 1,25-dihydroxyvitamin D(3) 24-hydroxylase, mitochondrial|25-hydroxyvitamin D-24-hydroxylase|cytochrome P450 24A1|cytochrome P450, 24|cytochrome P450, 24a1|cytochrome P450-CC24|vitamin D(3) 24-hydroxylase |
Swissprots | Q64441 |
Accessions | EDL06583 Q64441 AK016668 AK143984 BAE25646 AK159109 BAE34825 AK159481 BAE35118 AK159527 BAE35156 AK159852 BAE35429 AK159954 BAE35510 AK159976 BAE35528 AK164697 BAE37882 BC109139 AAI09140 BC109140 AAI09141 D49438 BAA08416 D89669 BAA21843 NM_009996 NP_034126 |
Function | Has a role in maintaining calcium homeostasis. Catalyzes the NADPH-dependent 24-hydroxylation of calcidiol (25- hydroxyvitamin D(3)) and calcitriol (1-alpha,25-dihydroxyvitamin D(3)). The enzyme can perform up to 6 rounds of hydroxylation of calcitriol leading to calcitroic acid. |
Subcellular Location | Mitochondrion. |
Top Pathways | MicroRNAs in cancer, Steroid biosynthesis |
CYP24 CRISPR/Cas9 KO Plasmid (m) - sc-419901 from Santa Cruz Biotechnology
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CYP24 HDR Plasmid (m) - sc-419901-HDR from Santa Cruz Biotechnology
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CYP24 Double Nickase Plasmid (m) - sc-419901-NIC from Santa Cruz Biotechnology
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CYP24 Double Nickase Plasmid (m2) - sc-419901-NIC-2 from Santa Cruz Biotechnology
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CYP24 CRISPR Activation Plasmid (m) - sc-419901-ACT from Santa Cruz Biotechnology
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CYP24 CRISPR Activation Plasmid (m2) - sc-419901-ACT-2 from Santa Cruz Biotechnology
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CYP24 Lentiviral Activation Particles (m) - sc-419901-LAC from Santa Cruz Biotechnology
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CYP24 Lentiviral Activation Particles (m2) - sc-419901-LAC-2 from Santa Cruz Biotechnology
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CYP24 siRNA (m) - sc-44653 from Santa Cruz Biotechnology
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CYP24 shRNA Plasmid (m) - sc-44653-SH from Santa Cruz Biotechnology
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CYP24 shRNA (m) Lentiviral Particles - sc-44653-V from Santa Cruz Biotechnology
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CompoZr® Knockout ZFN Kit - CKOZFN29498 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND29498 from Sigma-Aldrich
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CYP24A1 siRNA (Mouse) - CRM0933 from Cohesion Biosciences
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CYP24A1 - MBS8208304 from MyBioSource
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shRNA set against Mouse CYP24A1 (NM_009996.3) - SHH272925 from Creative biogene
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shRNA set against Mouse Cyp24a1(NM_009996.3) - SHG215519 from Creative biogene
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Mouse CYP24A1 siRNA - orb280409 from Biorbyt
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CYP24A1 shRNA Plasmid (Mouse) - CHM0933 from Cohesion Biosciences
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CYP24A1 miRNA 3'UTR clone - MiUTR1M-03521 from Creative biogene
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