Gene Symbol | VAX2 |
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Entrez Gene | 25806 |
Alt Symbol | DRES93 |
Species | Human |
Gene Type | protein-coding |
Description | ventral anterior homeobox 2 |
Other Description | - |
Swissprots | Q53Y33 Q9UIW0 |
Accessions | EAW99792 Q9UIW0 AB593145 BAJ84079 BC006336 AAH06336 BT007035 AAP35683 Y17791 CAB56166 XM_006711982 XP_006712045 XM_011532749 XP_011531051 XM_011532750 XP_011531052 XM_011532751 XP_011531053 XM_011532752 XP_011531054 NM_012476 NP_036608 |
Function | Transcription factor that may function in dorsoventral specification of the forebrain. Regulates the expression of Wnt signaling antagonists including the expression of a truncated TCF7L2 isoform that cannot bind CTNNB1 and acts therefore as a potent dominant-negative Wnt antagonist. Plays a crucial role in eye development and, in particular, in the specification of the ventral optic vesicle (By similarity). May be a regulator of axial polarization in the retina. {ECO:0000250}. |
Subcellular Location | Nucleus {ECO:0000305}. |
VAX2 CRISPR/Cas9 KO Plasmid (h) - sc-407255 from Santa Cruz Biotechnology
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VAX2 HDR Plasmid (h) - sc-407255-HDR from Santa Cruz Biotechnology
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VAX2 Double Nickase Plasmid (h) - sc-407255-NIC from Santa Cruz Biotechnology
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VAX2 Double Nickase Plasmid (h2) - sc-407255-NIC-2 from Santa Cruz Biotechnology
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VAX2 CRISPR Activation Plasmid (h) - sc-407255-ACT from Santa Cruz Biotechnology
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VAX2 CRISPR Activation Plasmid (h2) - sc-407255-ACT-2 from Santa Cruz Biotechnology
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VAX2 Lentiviral Activation Particles (h) - sc-407255-LAC from Santa Cruz Biotechnology
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VAX2 Lentiviral Activation Particles (h2) - sc-407255-LAC-2 from Santa Cruz Biotechnology
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VAX2 siRNA (h) - sc-76891 from Santa Cruz Biotechnology
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VAX2 shRNA Plasmid (h) - sc-76891-SH from Santa Cruz Biotechnology
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VAX2 shRNA (h) Lentiviral Particles - sc-76891-V from Santa Cruz Biotechnology
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MISSION® esiRNA - EHU008591 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN22651 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND22651 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR01267 from Sigma-Aldrich
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VAX2 siRNA (Human) - CRH8510 from Cohesion Biosciences
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VAX2 RNAi - H00025806-R01 from Novus Biologicals
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VAX2 - MBS8200129 from MyBioSource
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shRNA set against Human VAX2 (NM_012476.2) - SHH442400 from Creative biogene
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VAX2 CRISPR/Cas9 KO Plasmid (h2) - sc-407255-KO-2 from Santa Cruz Biotechnology
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VAX2 HDR Plasmid (h2) - sc-407255-HDR-2 from Santa Cruz Biotechnology
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Human VAX2 siRNA - orb269012 from Biorbyt
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VAX2 shRNA Plasmid (Human) - CHH8510 from Cohesion Biosciences
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