ACSL4

Gene Symbol ACSL4
Entrez Gene 2182
Alt Symbol ACS4, FACL4, LACS4, MRX63, MRX68
Species Human
Gene Type protein-coding
Description acyl-CoA synthetase long-chain family member 4
Other Description LACS 4|acyl-CoA synthetase 4|fatty-acid-Coenzyme A ligase, long-chain 4|lignoceroyl-CoA synthase|long-chain acyl-CoA synthetase 4|long-chain fatty-acid-Coenzyme A ligase 4|long-chain-fatty-acid--CoA ligase 4
Swissprots D3DUY2 O60488 Q5JWV8 O60848 O60849
Accessions BAB88649 EAX02671 EAX02672 EAX02673 EAX02674 O60488 AB061713 BAB86900 AB061714 BAB86901 AF030555 AAC17493 AK292070 BAF84759 AK294915 BAG58000 AK307566 BC034959 AAH34959 BQ016115 CN310691 DQ890835 ABM81761 DQ893990 ABM84916 DR004263 Y12777 CAA73314 Y13058 CAA73501 XM_005262108 XP_005262165 XM_005262109 XP_005262166 XM_005262110 XP_005262167 XM_006724635 XP_006724698 XM_011530888 XP_011529190 XM_011530889 XP_011529191 NM_004458 NP_004449 NM_022977 NP_075266
Function Activation of long-chain fatty acids for both synthesis of cellular lipids, and degradation via beta-oxidation. Preferentially uses arachidonate and eicosapentaenoate as substrates.
Subcellular Location Mitochondrion outer membrane {ECO:0000250}; Single-pass type III membrane protein {ECO:0000250}. Peroxisome membrane {ECO:0000250}; Single-pass type III membrane protein {ECO:0000250}. Microsome membrane {ECO:0000250}; Single-pass type III membrane protein {ECO:0000250}. Endoplasmic reticulum membrane {ECO:0000250}; Single-pass type III membrane protein {ECO:0000250}.
Top Pathways Adipocytokine signaling pathway, PPAR signaling pathway, Peroxisome, Fatty acid biosynthesis, Fatty acid degradation

ACSL4 (A-5) - sc-271800 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
ACSL4 (A-5): sc-271800. Immunofluorescence staining of methanol-fixed HeLa cells showing mitochondrial localization.

ACSL4 (C-19) - sc-47995 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

ACSL4 (F-4) - sc-365230 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
ACSL4 (F-4): sc-365230. Western blot analysis of ACSL4 expression in non-transfected 293: sc-110760 (A), human ACSL4 transfected 293: sc-173428 (B), Hep G2 (C) and HeLa (D) whole cell lysates.

ACSL4 (H-53) - sc-134507 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
ACSL4 (H-53): sc-134507. Western blot analysis of ACSL4 expression in Hep G2 whole cell lysate.

ACSL4 (K-12) - sc-47996 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

ACSL4 (N-18) - sc-47997 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
ACSL4 (N-18): sc-47997. Western blot analysis of ACSL4 expression in Hep G2 whole cell lysate.

Anti-FACL4 antibody - ab38420 from Abcam

Prices $384.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
ICC/IF image of ab38420 stained HepG2 cells. The cells were 4% formaldehyde fixed (10 min) and then incubated in 1%BSA / 10% normal goat serum / 0.3M glycine in 0.1% PBS-Tween for 1h to permeabilise the cells and block non-specific protein-protein interactions. The cells were then incubated with the antibody ab38420 at 10µg/ml overnight at +4°C. The secondary antibody (pseudo-colored green) was Alexa Fluor® 488 goat anti- rabbit (ab150081) IgG (H+L) preadsorbed, used at a 1/1000 dilution for 1h. Alexa Fluor® 594 WGA was used to label plasma membranes (pseudo-colored red) at a 1/200 dilution for 1h at room temperature. DAPI was used to stain the cell nuclei (pseudo-colored blue) at a concentration of 1.43µM for 1hour at room temperature.

Anti-FACL4 antibody [EPR8640] - ab155282 from Abcam

Prices $99.00
Sizes 10 µl
Host Rabbit
Clonality Monoclonal
Clone EPR8640
All lanes : Anti-FACL4 antibody [EPR8640] (ab155282) at 1/10000 dilutionLane 1 : HepG2 lysateLane 2 : HeLa lysateLane 3 : 293T lysateLane 4 : Fetal kidney lysate, humanLysates/proteins at 10 µg per lane.

Anti-FACL4 antibody - Aminoterminal end - ab70937 from Abcam

Prices $359.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Anti-FACL4 antibody - Aminoterminal end (ab70937) at 1/100 dilution + 293 cell lysate at 12.5 µg

Anti-FACL4 antibody - Carboxyterminal end - ab137525 from Abcam

Prices $378.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
All lanes : Anti-FACL4 antibody - Carboxyterminal end (ab137525) at 1/1000 dilutionLane 1 : HeLa whole cell lysateLane 2 : NT2D1 whole cell lysateLysates/proteins at 30 µg per lane.

Anti-ACSL4 / FACL4 Antibody (aa236-267) - LS-C98511 from LifeSpan Bioscience

Prices $295.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
Formalin-fixed and paraffin-embedded human cancer tissue reacted with the primary antibody, which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated. BC = breast carcinoma; HC = hepatocarcinoma.

Anti-ACSL4 / FACL4 Antibody (N-Terminus) IHC-plus™ - LS-B5818 from LifeSpan Bioscience

Prices $450.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Anti-ACSL4 antibody IHC of human brain, cortex. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B5818 concentration 5 ug/ml.

Anti-ACSL4 / FACL4 Antibody (aa658-670) IHC-plus™ - LS-B4440 from LifeSpan Bioscience

Prices $395.00
Sizes 50 µg
Host Goat
Clonality Polyclonal
Anti-ACSL4 antibody IHC of human small intestine. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B4440 concentration 3.75 ug/ml.

Anti-ACSL4 / FACL4 Antibody (aa244-274, Biotin) - LS-C212587 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-ACSL4 / FACL4 Antibody (aa244-274, FITC) - LS-C212588 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-ACSL4 / FACL4 Antibody (aa244-274, Azide-free, HRP) - LS-C212589 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-ACSL4 / FACL4 Antibody (aa244-274, AP) - LS-C212585 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-ACSL4 / FACL4 Antibody (aa244-274, APC) - LS-C212586 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-ACSL4 / FACL4 Antibody (aa244-274, PE) - LS-C212590 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-ACSL4 / FACL4 Antibody (aa27-56, APC) - LS-C212592 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-ACSL4 / FACL4 Antibody (aa27-56, FITC) - LS-C212594 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-ACSL4 / FACL4 Antibody (aa27-56, AP) - LS-C212591 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-ACSL4 / FACL4 Antibody (aa27-56, Biotin) - LS-C212593 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-ACSL4 / FACL4 Antibody (aa27-56, Azide-free, HRP) - LS-C212595 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-ACSL4 / FACL4 Antibody (aa27-56, PE) - LS-C212596 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal
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