Gene Symbol | ACSL4 |
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Entrez Gene | 2182 |
Alt Symbol | ACS4, FACL4, LACS4, MRX63, MRX68 |
Species | Human |
Gene Type | protein-coding |
Description | acyl-CoA synthetase long-chain family member 4 |
Other Description | LACS 4|acyl-CoA synthetase 4|fatty-acid-Coenzyme A ligase, long-chain 4|lignoceroyl-CoA synthase|long-chain acyl-CoA synthetase 4|long-chain fatty-acid-Coenzyme A ligase 4|long-chain-fatty-acid--CoA ligase 4 |
Swissprots | D3DUY2 O60488 Q5JWV8 O60848 O60849 |
Accessions | BAB88649 EAX02671 EAX02672 EAX02673 EAX02674 O60488 AB061713 BAB86900 AB061714 BAB86901 AF030555 AAC17493 AK292070 BAF84759 AK294915 BAG58000 AK307566 BC034959 AAH34959 BQ016115 CN310691 DQ890835 ABM81761 DQ893990 ABM84916 DR004263 Y12777 CAA73314 Y13058 CAA73501 XM_005262108 XP_005262165 XM_005262109 XP_005262166 XM_005262110 XP_005262167 XM_006724635 XP_006724698 XM_011530888 XP_011529190 XM_011530889 XP_011529191 NM_004458 NP_004449 NM_022977 NP_075266 |
Function | Activation of long-chain fatty acids for both synthesis of cellular lipids, and degradation via beta-oxidation. Preferentially uses arachidonate and eicosapentaenoate as substrates. |
Subcellular Location | Mitochondrion outer membrane {ECO:0000250}; Single-pass type III membrane protein {ECO:0000250}. Peroxisome membrane {ECO:0000250}; Single-pass type III membrane protein {ECO:0000250}. Microsome membrane {ECO:0000250}; Single-pass type III membrane protein {ECO:0000250}. Endoplasmic reticulum membrane {ECO:0000250}; Single-pass type III membrane protein {ECO:0000250}. |
Top Pathways | Adipocytokine signaling pathway, PPAR signaling pathway, Peroxisome, Fatty acid biosynthesis, Fatty acid degradation |
ACSL4 CRISPR/Cas9 KO Plasmid (h) - sc-401649 from Santa Cruz Biotechnology
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ACSL4 HDR Plasmid (h) - sc-401649-HDR from Santa Cruz Biotechnology
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ACSL4 Double Nickase Plasmid (h) - sc-401649-NIC from Santa Cruz Biotechnology
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ACSL4 Double Nickase Plasmid (h2) - sc-401649-NIC-2 from Santa Cruz Biotechnology
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ACSL4 CRISPR Activation Plasmid (h) - sc-401649-ACT from Santa Cruz Biotechnology
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ACSL4 CRISPR Activation Plasmid (h2) - sc-401649-ACT-2 from Santa Cruz Biotechnology
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ACSL4 Lentiviral Activation Particles (h) - sc-401649-LAC from Santa Cruz Biotechnology
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ACSL4 Lentiviral Activation Particles (h2) - sc-401649-LAC-2 from Santa Cruz Biotechnology
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ACSL4 siRNA (h) - sc-60619 from Santa Cruz Biotechnology
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ACSL4 shRNA Plasmid (h) - sc-60619-SH from Santa Cruz Biotechnology
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ACSL4 shRNA (h) Lentiviral Particles - sc-60619-V from Santa Cruz Biotechnology
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FACL4 RNAi - H00002182-R01 from Novus Biologicals
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FACL4 RNAi - H00002182-R02 from Novus Biologicals
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MISSION® esiRNA - EHU087251 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN2754 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND2754 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR11694 from Sigma-Aldrich
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ACSL4 siRNA (Human) - CRH1520 from Cohesion Biosciences
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ACSL4 - MBS8232389 from MyBioSource
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shRNA set against Human ACSL4 (NM_004458.2) - SHH230746 from Creative biogene
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shRNA set against Human ACSL4(NM_022977.2) - SHG035687 from Creative biogene
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shRNA set against Human ACSL4(NM_004458.2) - SHG035809 from Creative biogene
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Human ACSL4 siRNA - orb262022 from Biorbyt
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ACSL4 shRNA Plasmid (Human) - CHH1520 from Cohesion Biosciences
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ACSL4 miRNA 3'UTR clone - MiUTR1H-00123 from Creative biogene
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