| Gene Symbol | ACSL4 |
|---|---|
| Entrez Gene | 2182 |
| Alt Symbol | ACS4, FACL4, LACS4, MRX63, MRX68 |
| Species | Human |
| Gene Type | protein-coding |
| Description | acyl-CoA synthetase long-chain family member 4 |
| Other Description | LACS 4|acyl-CoA synthetase 4|fatty-acid-Coenzyme A ligase, long-chain 4|lignoceroyl-CoA synthase|long-chain acyl-CoA synthetase 4|long-chain fatty-acid-Coenzyme A ligase 4|long-chain-fatty-acid--CoA ligase 4 |
| Swissprots | D3DUY2 O60488 Q5JWV8 O60848 O60849 |
| Accessions | BAB88649 EAX02671 EAX02672 EAX02673 EAX02674 O60488 AB061713 BAB86900 AB061714 BAB86901 AF030555 AAC17493 AK292070 BAF84759 AK294915 BAG58000 AK307566 BC034959 AAH34959 BQ016115 CN310691 DQ890835 ABM81761 DQ893990 ABM84916 DR004263 Y12777 CAA73314 Y13058 CAA73501 XM_005262108 XP_005262165 XM_005262109 XP_005262166 XM_005262110 XP_005262167 XM_006724635 XP_006724698 XM_011530888 XP_011529190 XM_011530889 XP_011529191 NM_004458 NP_004449 NM_022977 NP_075266 |
| Function | Activation of long-chain fatty acids for both synthesis of cellular lipids, and degradation via beta-oxidation. Preferentially uses arachidonate and eicosapentaenoate as substrates. |
| Subcellular Location | Mitochondrion outer membrane {ECO:0000250}; Single-pass type III membrane protein {ECO:0000250}. Peroxisome membrane {ECO:0000250}; Single-pass type III membrane protein {ECO:0000250}. Microsome membrane {ECO:0000250}; Single-pass type III membrane protein {ECO:0000250}. Endoplasmic reticulum membrane {ECO:0000250}; Single-pass type III membrane protein {ECO:0000250}. |
| Top Pathways | Adipocytokine signaling pathway, PPAR signaling pathway, Peroxisome, Fatty acid biosynthesis, Fatty acid degradation |