| Gene Symbol |
LILRB2
|
| Entrez Gene |
10288
|
| Alt Symbol |
CD85D, ILT-4, ILT4, LIR-2, LIR2, MIR-10, MIR10
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 2
|
| Other Description |
CD85 antigen-like family member D|Ig-like transcript 4|leukocyte immunoglobulin-like receptor subfamily B member 2|monocyte/macrophage immunoglobulin-like receptor 10
|
| Swissprots |
Q8N423 A8MU67 C9JF29 O75017 Q8NHJ7 Q8NHJ8
|
| Accessions |
EAW72224 Q8N423 AF000574 AAB88119 AF004231 AAB67711 AF011565 AAC51882 AF011566 AAC51883 AF025528 AAB87662 AF283986 AAL36990 AF283987 AAL36991 AK226015 AK297041 BAH12481 AK297071 BAH12489 AK298649 BAH12836 AK310263 BC025766 BC036827 AAH36827 DC429031 DC429053 DQ655938 EU832815 ACE87826 EU915606 ACK56072 GQ129422 ACT64556 XM_006722966 XP_006723029 XM_006722968 XP_006723031 XM_006726143 XP_006726206 XM_006726241 XP_006726304 XM_006726278 XP_006726341 XM_006726280 XP_006726343 XM_011526307 XP_011524609 XM_011526308 XP_011524610 XM_011526309 XP_011524611 XM_011526310 XP_011524612 XM_011526311 XP_011524613 XM_011526312 XP_011524614 XM_011526313 XP_011524615 XM_011526314 XP_011524616 XM_011526315 XP_011524617 XM_011547046 XP_011545348 XM_011547047 XP_011545349 XM_011547048 XP_011545350 XM_011547049 XP_011545351 XM_011547050 XP_011545352 XM_011547051 XP_011545353 XM_011547052 XP_011545354 XM_011547053 XP_011545355 XM_011547054 XP_011545356 XM_011547055 XP_011545357 XM_011547056 XP_011545358 XM_011547057 XP_011545359 XM_011547058 XP_011545360 XM_011548578 XP_011546880 XM_011548579 XP_011546881 XM_011548580 XP_011546882 XM_011548581 XP_011546883 XM_011548582 XP_011546884 XM_011548583 XP_011546885 XM_011548584 XP_011546886 XM_011548585 XP_011546887 XM_011548632 XP_011546934 XM_011548633 XP_011546935 XM_011548634 XP_011546936 XM_011548635 XP_011546937 XM_011548636 XP_011546938 XM_011548637 XP_011546939 XR_935713 XR_952180 XR_952181 XR_952182 XR_953141 XR_953162 NM_001080978 NP_001074447 NM_001278403 NP_001265332 NM_001278404 NP_001265333 NM_001278405 NP_001265334 NM_001278406 NP_001265335 NM_005874 NP_005865 NR_103521
|
| Function |
Receptor for class I MHC antigens. Recognizes a broad spectrum of HLA-A, HLA-B, HLA-C and HLA-G alleles. Involved in the down-regulation of the immune response and the development of tolerance. Competes with CD8A for binding to class I MHC antigens. Inhibits FCGR1A-mediated phosphorylation of cellular proteins and mobilization of intracellular calcium ions. {ECO:0000269|PubMed:11875462, ECO:0000269|PubMed:12853576, ECO:0000269|PubMed:9548455, ECO:0000269|PubMed:9842885}.
|
| Subcellular Location |
Membrane; Single-pass type I membrane protein.
|
| Tissue Specificity |
Expressed on monocytes and B-cells, and at lower levels on dendritic cells. Detected at low levels in natural killer (NK) cells. {ECO:0000269|PubMed:9548455, ECO:0000269|PubMed:9842885}.
|
| Top Pathways |
Osteoclast differentiation
|
