LILRB2

Gene Symbol	LILRB2
Entrez Gene	10288
Alt Symbol	CD85D, ILT-4, ILT4, LIR-2, LIR2, MIR-10, MIR10
Species	Human
Gene Type	protein-coding
Description	leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 2
Other Description	CD85 antigen-like family member D|Ig-like transcript 4|leukocyte immunoglobulin-like receptor subfamily B member 2|monocyte/macrophage immunoglobulin-like receptor 10
Swissprots	Q8N423 A8MU67 C9JF29 O75017 Q8NHJ7 Q8NHJ8
Accessions	EAW72224 Q8N423 AF000574 AAB88119 AF004231 AAB67711 AF011565 AAC51882 AF011566 AAC51883 AF025528 AAB87662 AF283986 AAL36990 AF283987 AAL36991 AK226015 AK297041 BAH12481 AK297071 BAH12489 AK298649 BAH12836 AK310263 BC025766 BC036827 AAH36827 DC429031 DC429053 DQ655938 EU832815 ACE87826 EU915606 ACK56072 GQ129422 ACT64556 XM_006722966 XP_006723029 XM_006722968 XP_006723031 XM_006726143 XP_006726206 XM_006726241 XP_006726304 XM_006726278 XP_006726341 XM_006726280 XP_006726343 XM_011526307 XP_011524609 XM_011526308 XP_011524610 XM_011526309 XP_011524611 XM_011526310 XP_011524612 XM_011526311 XP_011524613 XM_011526312 XP_011524614 XM_011526313 XP_011524615 XM_011526314 XP_011524616 XM_011526315 XP_011524617 XM_011547046 XP_011545348 XM_011547047 XP_011545349 XM_011547048 XP_011545350 XM_011547049 XP_011545351 XM_011547050 XP_011545352 XM_011547051 XP_011545353 XM_011547052 XP_011545354 XM_011547053 XP_011545355 XM_011547054 XP_011545356 XM_011547055 XP_011545357 XM_011547056 XP_011545358 XM_011547057 XP_011545359 XM_011547058 XP_011545360 XM_011548578 XP_011546880 XM_011548579 XP_011546881 XM_011548580 XP_011546882 XM_011548581 XP_011546883 XM_011548582 XP_011546884 XM_011548583 XP_011546885 XM_011548584 XP_011546886 XM_011548585 XP_011546887 XM_011548632 XP_011546934 XM_011548633 XP_011546935 XM_011548634 XP_011546936 XM_011548635 XP_011546937 XM_011548636 XP_011546938 XM_011548637 XP_011546939 XR_935713 XR_952180 XR_952181 XR_952182 XR_953141 XR_953162 NM_001080978 NP_001074447 NM_001278403 NP_001265332 NM_001278404 NP_001265333 NM_001278405 NP_001265334 NM_001278406 NP_001265335 NM_005874 NP_005865 NR_103521
Function	Receptor for class I MHC antigens. Recognizes a broad spectrum of HLA-A, HLA-B, HLA-C and HLA-G alleles. Involved in the down-regulation of the immune response and the development of tolerance. Competes with CD8A for binding to class I MHC antigens. Inhibits FCGR1A-mediated phosphorylation of cellular proteins and mobilization of intracellular calcium ions. {ECO:0000269|PubMed:11875462, ECO:0000269|PubMed:12853576, ECO:0000269|PubMed:9548455, ECO:0000269|PubMed:9842885}.
Subcellular Location	Membrane; Single-pass type I membrane protein.
Tissue Specificity	Expressed on monocytes and B-cells, and at lower levels on dendritic cells. Detected at low levels in natural killer (NK) cells. {ECO:0000269|PubMed:9548455, ECO:0000269|PubMed:9842885}.
Top Pathways	Osteoclast differentiation

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human LILRB2 full length protein - ab160928 from Abcam Category Protein Source Wheat germ Species Human

Human LILRB2 protein fragment - ab151846 from Abcam Category Protein Source HEK 293 cells Species Human

LILRB2 / ILT4 Antibody Blocking Peptide - LS-E23308 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

Recombinant Human ILT4/CD85d/LILRB2 Protein - H00010288-P01 from Novus Biologicals Category Protein Prices $369.00, $529.00 Sizes 10 µg, 25 µg Source Wheat Germ Species Human

ILT4/CD85d/LILRB2 Recombinant Protein - H00010288-G01 from Novus Biologicals Category Protein Prices $579.00 Sizes 10 µg Species Human

Recombinant Human LILRB2/CD85d/ILT4 Fc Chimera, CF - 2078-T4-050 from R&D Systems Category Protein Source Mouse myeloma cell line, NS0-derived

Recombinant Human LILRB2/CD85d/ILT4(HEK293-expressed), CF - 8429-T4-050 from R&D Systems Category Protein Source Human embryonic kidney cell, HEK293-derived, Gln22-His458, with a C-terninal 6-His tag

Human LILRB2 protein (His Tag) - orb139282 from Biorbyt Category Protein Prices $238.00, $400.00 Sizes 20 μg, 50 μg Source Human Cells Species Human

Human ILT4 protein - orb49510 from Biorbyt Category Protein Prices $255.00, $349.00, $1,904.00, $2,695.00 Sizes 10 μg, 50 μg, 500 μg, 1 mg Source HEK293

Human LILRB2 protein - orb139283 from Biorbyt Category Protein Prices $400.00, $612.00 Sizes 50 μg, 100 μg Source Human Cells Species Human

CD85d / LILRB2 - H00010288-G01 from Acris Antibodies Category Protein Prices $550.00 Sizes 10 µg Species Human

CD85d / LILRB2 - H00010288-P01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Source in vitro transl. Species Human

CD85d / LILRB2 - H00010288-P01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Source in vitro transl. Species Human

Leukocyte Immunoglobulin-Like Receptor Subfamily B Member 2, LIR-2, Human, Recombinant - 19-C485 from ARP American Research Products Category Protein Prices $109.00 Sizes 10 µg Source HEK293 Species Human

LILRB2 Recombinant Protein - 96-515 from ProSci Category Protein Prices $375.00 Sizes 100 µg Source HEK293 cells Species Human

LILRB2 fusion protein - Ag5336 from Proteintech Group Category Protein Prices $199.00 Sizes 50 μg Source E. coli -derived, PGEX-4T Species Human

Recombinant Human LIR-2 Protein - BP001389-C485 from Syd Labs Category Protein Prices $98.00, $252.00, $2,640.00 Sizes 10 µg, 50 µg, 1 mg Source HEK 293-derived. Species Human

Recombinant Human LILRB2, His tagged - LILRB2-8639H from Creative Biomart Category Protein Source Human Cells Species Human

Recombinant Human LILRB2, Fc tagged - LILRB2-391H from Creative Biomart Category Protein Source Human Cells Species Human

Recombinant Human LILRB2, His-tagged - LILRB2-115H from Creative Biomart Category Protein Source HEK293 Species Human

Recombinant Human LILRB2, GST-tagged - LILRB2-581H from Creative Biomart Category Protein Source E.coli Species Human

Recombinant Human LILRB2, Fc Chimera - LILRB2-253H from Creative Biomart Category Protein Source NSO cells Species Human

Recombinant Leukocyte Immunoglobulin Like Receptor Subfamily B, Member 2 (LILRB2) - RPB153Hu01 from Uscn Life Science Inc. Category Protein Source E.coli Species Human

Human LILRB2 / ILT4 / LIR-2 Protein (His Tag) - 14132-H08H-20 from Sino Biological Category Protein Prices $78.00, $178.00 Sizes 20 µg, 50 µg Source Human Cells Species Human

Human LILRB2 / ILT4 / LIR-2 Protein (Fc Tag) - 14132-H02H-50 from Sino Biological Category Protein Prices $178.00, $298.00 Sizes 50 µg, 100 µg Source Human Cells Species Human

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