| Gene Symbol | MSI1 |
|---|---|
| Entrez Gene | 4440 |
| Alt Symbol | - |
| Species | Human |
| Gene Type | protein-coding |
| Description | musashi RNA-binding protein 1 |
| Other Description | RNA-binding protein Musashi homolog 1|musashi-1|musashi1 |
| Swissprots | Q96PU1 Q96PU2 Q96PU0 O43347 Q96PU3 |
| Accessions | AAB95636 CBF67590 CBU92464 EAW98185 EAW98186 EAW98187 O43347 AB012851 BAA33962 AB072590 BAB69767 AB072591 BAB69768 AB072592 BAB69769 AB073212 BAB70469 AI583233 AK023262 BAG51178 BC140380 AAI40381 BC146463 AAI46464 BX393884 XM_006719403 XP_006719466 XM_006719404 XP_006719467 XM_011538361 XP_011536663 XM_011538362 XP_011536664 XM_011538363 XP_011536665 XM_011538364 XP_011536666 XM_011538365 XP_011536667 XM_011538366 XP_011536668 XM_011538367 XP_011536669 XM_011538368 XP_011536670 XM_011538369 XP_011536671 XM_011538370 XP_011536672 XM_011538371 XP_011536673 NM_002442 NP_002433 |
| Function | RNA binding protein that regulates the expression of target mRNAs at the translation level. Regulates expression of the NOTCH1 antagonist NUMB. Binds RNA containing the sequence 5'- GUUAGUUAGUUAGUU-3' and other sequences containing the pattern 5'- [GA]U(1-3)AGU-3'. May play a role in the proliferation and maintenance of stem cells in the central nervous system (By similarity). {ECO:0000250}. |
| Subcellular Location | Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}. |
| Tissue Specificity | Detected in fetal kidney, brain, liver and lung, and in adult brain and pancreas. Detected in hepatoma cell lines. {ECO:0000269|PubMed:12054577, ECO:0000269|PubMed:9790759}. |
| Top Pathways | mRNA surveillance pathway |