Gene Symbol | MSI1 |
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Entrez Gene | 4440 |
Alt Symbol | - |
Species | Human |
Gene Type | protein-coding |
Description | musashi RNA-binding protein 1 |
Other Description | RNA-binding protein Musashi homolog 1|musashi-1|musashi1 |
Swissprots | Q96PU1 Q96PU2 Q96PU0 O43347 Q96PU3 |
Accessions | AAB95636 CBF67590 CBU92464 EAW98185 EAW98186 EAW98187 O43347 AB012851 BAA33962 AB072590 BAB69767 AB072591 BAB69768 AB072592 BAB69769 AB073212 BAB70469 AI583233 AK023262 BAG51178 BC140380 AAI40381 BC146463 AAI46464 BX393884 XM_006719403 XP_006719466 XM_006719404 XP_006719467 XM_011538361 XP_011536663 XM_011538362 XP_011536664 XM_011538363 XP_011536665 XM_011538364 XP_011536666 XM_011538365 XP_011536667 XM_011538366 XP_011536668 XM_011538367 XP_011536669 XM_011538368 XP_011536670 XM_011538369 XP_011536671 XM_011538370 XP_011536672 XM_011538371 XP_011536673 NM_002442 NP_002433 |
Function | RNA binding protein that regulates the expression of target mRNAs at the translation level. Regulates expression of the NOTCH1 antagonist NUMB. Binds RNA containing the sequence 5'- GUUAGUUAGUUAGUU-3' and other sequences containing the pattern 5'- [GA]U(1-3)AGU-3'. May play a role in the proliferation and maintenance of stem cells in the central nervous system (By similarity). {ECO:0000250}. |
Subcellular Location | Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}. |
Tissue Specificity | Detected in fetal kidney, brain, liver and lung, and in adult brain and pancreas. Detected in hepatoma cell lines. {ECO:0000269|PubMed:12054577, ECO:0000269|PubMed:9790759}. |
Top Pathways | mRNA surveillance pathway |
Msi1 CRISPR/Cas9 KO Plasmid (h) - sc-404014 from Santa Cruz Biotechnology
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Msi1 HDR Plasmid (h) - sc-404014-HDR from Santa Cruz Biotechnology
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Msi1 Double Nickase Plasmid (h) - sc-404014-NIC from Santa Cruz Biotechnology
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Msi1 Double Nickase Plasmid (h2) - sc-404014-NIC-2 from Santa Cruz Biotechnology
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Msi1 CRISPR Activation Plasmid (h) - sc-404014-ACT from Santa Cruz Biotechnology
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Msi1 CRISPR Activation Plasmid (h2) - sc-404014-ACT-2 from Santa Cruz Biotechnology
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Msi1 Lentiviral Activation Particles (h) - sc-404014-LAC from Santa Cruz Biotechnology
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Msi1 Lentiviral Activation Particles (h2) - sc-404014-LAC-2 from Santa Cruz Biotechnology
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Msi1 siRNA (h) - sc-106836 from Santa Cruz Biotechnology
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Msi1 shRNA Plasmid (h) - sc-106836-SH from Santa Cruz Biotechnology
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Msi1 shRNA (h) Lentiviral Particles - sc-106836-V from Santa Cruz Biotechnology
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Musashi-1 RNAi - H00004440-R01 from Novus Biologicals
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CompoZr® Knockout ZFN Kit - CKOZFN14647 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND14647 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR00002 from Sigma-Aldrich
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MSI1 siRNA (Human) - CRH2972 from Cohesion Biosciences
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Msi1 CRISPR/Cas9 KO Plasmid (h2) - sc-404014-KO-2 from Santa Cruz Biotechnology
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Msi1 HDR Plasmid (h2) - sc-404014-HDR-2 from Santa Cruz Biotechnology
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shRNA set against Human MSI1 (NM_002442.3) - SHH345672 from Creative biogene
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MSI1 shRNA Plasmid (Human) - CHH2972 from Cohesion Biosciences
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MSI1 miRNA 3'UTR clone - MiUTR4H-TG11764 from Creative biogene
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