MYD88

Gene Symbol MYD88
Entrez Gene 4615
Alt Symbol MYD88D
Species Human
Gene Type protein-coding
Description myeloid differentiation primary response 88
Other Description myeloid differentiation primary response gene (88)|myeloid differentiation primary response protein MyD88
Swissprots J3KPU4 B4DKH8 Q99836 B4DKU4 Q53XS7 B4DQ72 J3KQJ6 B4DQ60 J3KQ87 P78397
Accessions EAW64520 EAW64521 Q99836 AB446470 BAG55247 AK097983 AK124685 AK296570 BAG59190 AK296716 BAG59306 AK298650 BAG60822 AK298666 BAG60834 AK300051 BAG61860 AK300448 BAG62170 AK304676 BAG65448 AL832906 BC013589 AAH13589 BP242808 BP339466 BT007376 AAP36040 BX537602 DC350705 EU831951 ACE87392 EU832045 ACE86707 U70451 AAB49967 U84408 AAC50954 XM_005265172 XP_005265229 XM_006713170 XP_006713233 NM_001172566 NP_001166037 NM_001172567 NP_001166038 NM_001172568 NP_001166039 NM_001172569 NP_001166040 NM_002468 NP_002459
Function Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response. Acts via IRAK1, IRAK2, IRF7 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Increases IL-8 transcription. Involved in IL-18-mediated signaling pathway. Activates IRF1 resulting in its rapid migration into the nucleus to mediate an efficient induction of IFN-beta, NOS2/INOS, and IL12A genes. MyD88-mediated signaling in intestinal epithelial cells is crucial for maintenance of gut homeostasis and controls the expression of the antimicrobial lectin REG3G in the small intestine. {ECO:0000269|PubMed:15361868, ECO:0000269|PubMed:18292575, ECO:0000269|PubMed:19506249, ECO:0000269|PubMed:9013863}.
Subcellular Location Cytoplasm {ECO:0000269|PubMed:15361868, ECO:0000269|PubMed:15492225}.
Tissue Specificity Ubiquitous. {ECO:0000269|PubMed:8957090}.
Top Pathways Herpes simplex infection, Legionellosis, Tuberculosis, Pertussis, Salmonella infection

MyD88 CRISPR/Cas9 KO Plasmid (h) - sc-417166 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

MyD88 HDR Plasmid (h) - sc-417166-HDR from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

MyD88 Double Nickase Plasmid (h) - sc-417166-NIC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

MyD88 Double Nickase Plasmid (h2) - sc-417166-NIC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

MyD88 CRISPR Activation Plasmid (h) - sc-417166-ACT from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

MyD88 CRISPR Activation Plasmid (h2) - sc-417166-ACT-2 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

MyD88 Lentiviral Activation Particles (h) - sc-417166-LAC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

MyD88 Lentiviral Activation Particles (h2) - sc-417166-LAC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

MyD88 siRNA (h) - sc-35986 from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

MyD88 shRNA Plasmid (h) - sc-35986-SH from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

MyD88 shRNA (h) Lentiviral Particles - sc-35986-V from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

MyD88 siRNA (h2) - sc-44313 from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

MyD88 shRNA Plasmid (h2) - sc-44313-SH from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

MyD88 shRNA (h2) Lentiviral Particles - sc-44313-V from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

MyD88 RNAi - H00004615-R02 from Novus Biologicals

Category siRNA
Prices $399.00
Sizes 20 nmol
Species Reactivities Human

MISSION® esiRNA - EHU029771 from Sigma-Aldrich

Category siRNA
Prices $250.00
Sizes 50 µg

MISSION® esiRNA - EHU104311 from Sigma-Aldrich

Category siRNA
Prices $140.00, $250.00
Sizes 20 µg, 50 µg

CompoZr® Knockout ZFN Kit - CKOZFN14806 from Sigma-Aldrich

Category ZFN Kit
Prices $4,999.00
Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND14806 from Sigma-Aldrich

Category ZFN Kit
Prices $3,999.00
Sizes 1 kt

MISSION® 3′UTR Lenti GoClone™ - HUTR10313 from Sigma-Aldrich

Category miRNA

MYD88 siRNA (Human) - CRH3043 from Cohesion Biosciences

Category siRNA
Prices $340.00, $510.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

shRNA set against Human MYD88 (NM_002468.4) - SHH347620 from Creative biogene

Category siRNA
Species Reactivities Human

Human MYD88 siRNA - orb263545 from Biorbyt

Category siRNA
Prices $485.00, $629.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

MYD88 shRNA Plasmid (Human) - CHH3043 from Cohesion Biosciences

Category siRNA
Prices $500.00, $750.00
Sizes 150 µg, 300 µg
Species Reactivities Human

MYD88 miRNA 3'UTR clone - MiUTR3H-04732 from Creative biogene

Species Reactivities Human
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