MYD88

Gene Symbol MYD88
Entrez Gene 4615
Alt Symbol MYD88D
Species Human
Gene Type protein-coding
Description myeloid differentiation primary response 88
Other Description myeloid differentiation primary response gene (88)|myeloid differentiation primary response protein MyD88
Swissprots J3KPU4 B4DKH8 Q99836 B4DKU4 Q53XS7 B4DQ72 J3KQJ6 B4DQ60 J3KQ87 P78397
Accessions EAW64520 EAW64521 Q99836 AB446470 BAG55247 AK097983 AK124685 AK296570 BAG59190 AK296716 BAG59306 AK298650 BAG60822 AK298666 BAG60834 AK300051 BAG61860 AK300448 BAG62170 AK304676 BAG65448 AL832906 BC013589 AAH13589 BP242808 BP339466 BT007376 AAP36040 BX537602 DC350705 EU831951 ACE87392 EU832045 ACE86707 U70451 AAB49967 U84408 AAC50954 XM_005265172 XP_005265229 XM_006713170 XP_006713233 NM_001172566 NP_001166037 NM_001172567 NP_001166038 NM_001172568 NP_001166039 NM_001172569 NP_001166040 NM_002468 NP_002459
Function Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response. Acts via IRAK1, IRAK2, IRF7 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Increases IL-8 transcription. Involved in IL-18-mediated signaling pathway. Activates IRF1 resulting in its rapid migration into the nucleus to mediate an efficient induction of IFN-beta, NOS2/INOS, and IL12A genes. MyD88-mediated signaling in intestinal epithelial cells is crucial for maintenance of gut homeostasis and controls the expression of the antimicrobial lectin REG3G in the small intestine. {ECO:0000269|PubMed:15361868, ECO:0000269|PubMed:18292575, ECO:0000269|PubMed:19506249, ECO:0000269|PubMed:9013863}.
Subcellular Location Cytoplasm {ECO:0000269|PubMed:15361868, ECO:0000269|PubMed:15492225}.
Tissue Specificity Ubiquitous. {ECO:0000269|PubMed:8957090}.
Top Pathways Herpes simplex infection, Legionellosis, Tuberculosis, Pertussis, Salmonella infection

MyD88 (D80F5) Rabbit mAb - 4283 from Cell Signaling Technology

Prices $246.00
Sizes 100 µl (10 western blots)
Host Rabbit
Clonality Monoclonal
Clone D80F5
Western blot analysis of extracts from Raji, A549, and THP-1 cells using MyD88 (D80F5) Rabbit mAb.

MyD88 Antibody - 3699 from Cell Signaling Technology

Prices $246.00
Sizes 100 µl (10 western blots)
Host Rabbit
Clonality Polyclonal
Western blot analysis of extracts from HeLa cells, either mock transfected or transfected with MyD88, using MyD88 Antibody.

MyD88 (N-19) - sc-8196 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
MyD88 (N-19): sc-8196. Western blot analysis of MyD88 expression in J774.A1 (A) and MCP-5 (B) whole cell lysates and mouse uterus extract (C).

MyD88 (HFL-296) - sc-11356 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
MyD88 (HFL-296): sc-11356. Western blot analysis of MyD88 expression in non-transfected (A) and human MyD88 transfected (B) CHO whole cell lysates.

MyD88 (E-11) - sc-74532 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
MyD88 (E-11): sc-74532. Western blot analysis of MyD88 expression in non-transfected (A) and human MyD88 transfected (B) CHO whole cell lysates.

MyD88 (B-1) - sc-136970 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
MyD88 (B-1): sc-136970. Immunoperoxidase staining of formalin fixed, paraffin-embedded human duodenum tissue showing cytoplasmic staining of glandular cells.

Anti-MyD88 antibody - ab2064 from Abcam

Prices $400.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
All lanes : Anti-MyD88 antibody (ab2064) at 1 µg/mlLane 1 : Wild type MEFs whole cell lysateLane 2 : Wild type MEFs whole cell lysateLane 3 : MyD88 knockout MEFs whole cell lysateLane 4 : MyD88 knockout MEFs whole cell lysateSecondaryHRP-conjugated goat anti-rabbit IgG polyclonal at 1/10000 dilutiondeveloped using the ECL techniquePerformed under reducing conditions.

Anti-MyD88 antibody - ab135693 from Abcam

Prices $385.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
ICC/IF image of ab135693 stained A549 cells. The cells were 4% formaldehyde fixed (10 min) and then incubated in 1%BSA / 10% normal goat serum / 0.3M glycine in 0.1% PBS-Tween for 1h to permeabilise the cells and block non-specific protein-protein interactions. The cells were then incubated with the antibody ab135693 at 5µg/ml overnight at +4°C. The secondary antibody (green) was DyLight® 488 goat anti- rabbit (ab96899) IgG (H+L) used at a 1/250 dilution for 1h. Alexa Fluor® 594 WGA was used to label plasma membranes (red) at a 1/200 dilution for 1h. DAPI was used to stain the cell nuclei (blue) at a concentration of 1.43µM.

Anti-MyD88 antibody - ab36076 from Abcam

Prices $385.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Anti-MyD88 antibody (ab36076) at 1 µg/ml + Jurkat (Human T cell lymphoblast-like cell line) Whole Cell Lysate at 10 µgSecondaryIRDye 680 Conjugated Goat Anti-Rabbit IgG (H+L) at 1/10000 dilutionPerformed under reducing conditions.

Anti-MyD88 antibody - ab196341 from Abcam

Prices $372.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-MyD88 antibody - ab131071 from Abcam

Prices $370.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-MyD88 antibody - ab89576 from Abcam

Prices $376.00
Sizes 50 µg
Host Mouse
Clonality Polyclonal
Anti-MyD88 antibody (ab89576) at 1 µg/ml + human liver tissue lysate at 50 µg

Anti-MyD88 antibody - ab94527 from Abcam

Prices $376.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Anti-MyD88 antibody (ab94527) at 1 µg/ml (in 5% skim milk / PBS buffer) + Human fetal muscle lysate at 10 µgSecondaryHRP conjugated anti-Rabbit IgG at 1/50000 dilution

Anti-MyD88 antibody [1B4] - ab119048 from Abcam

Prices $384.00
Sizes 100 µl
Host Mouse
Clonality Monoclonal
Clone 1B4
All lanes : Anti-MyD88 antibody [1B4] (ab119048) at 1/2000 dilutionLane 1 : HEK293T lysate transfected with pCMV6-ENTRY control cDNA Lane 2 : HEK293T lysate transfected with pCMV6-ENTRY MyD88 cDNA Lysates/proteins at 5 µg per lane.

Anti-MyD88 antibody [4D6] - ab107585 from Abcam

Prices $384.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone 4D6
Intracellular flow cytometric analysis of MyD88 antibody (ab107585) in Jurkat cells (0.5 ug). Shaded histogram represents cells without antibody; green represents isotype control; red represents anti-MyD88 antibody. Secondary antibody- anti-mouse IgG PE conjugated.

Anti-MyD88 antibody [EPR590(N)] - ab133739 from Abcam

Prices $385.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone EPR590(N)
Overlay histogram showing MCF7 cells stained with ab133739 (red line). The cells were fixed with 4% paraformaldehyde (10 min) and then permeabilized with 0.1% PBS-Tween for 20 min. The cells were then incubated in 1x PBS / 10% normal goat serum / 0.3M glycine to block non-specific protein-protein interactions followed by the antibody (ab133739, 1/10000 dilution) for 30 min at 22°C. The secondary antibody used was Alexa Fluor® 488 goat anti-rabbit IgG (H&L) (ab150077) at 1/2000 dilution for 30 min at 22°C. Isotype control antibody (black line) was rabbit IgG (monoclonal) (0.1μg/1x106 cells) used under the same conditions. Unlabelled sample (blue line) was also used as a control. Acquisition of >5,000 events were collected using a 20mW Argon ion laser (488nm) and 525/30 bandpass filter. This antibody gave a positive signal in MCF7 cells fixed with 80% methanol (5 min)/permeabilized with 0.1% PBS-Tween for 20 min used under the same conditions.

Anti-MYD88 Antibody (aa44-264) - LS-C344009 from LifeSpan Bioscience

Prices $325.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
MyD88 antibody IHC-paraffin: Human Intestinal Cancer Tissue.

Anti-MYD88 Antibody (clone 2B2) - LS-C172372 from LifeSpan Bioscience

Prices $325.00
Sizes 100 µl
Host Mouse
Clonality Monoclonal
Clone 2B2
IHC of paraffin-embedded Human thyroid tissue using anti-MYD88 mouse monoclonal antibody.

Anti-MYD88 Antibody (aa233-248) - LS-C9153 from LifeSpan Bioscience

Prices $415.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-MYD88 Antibody (N-Terminus) - LS-C9156 from LifeSpan Bioscience

Prices $475.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-MYD88 Antibody - LS-C18598 from LifeSpan Bioscience

Prices $390.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Anti-MYD88 Antibody - LS-C48267 from LifeSpan Bioscience

Prices $445.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-MYD88 Antibody - LS-C124199 from LifeSpan Bioscience

Prices $375.00
Sizes 20 µl
Host Rabbit
Clonality Polyclonal

Anti-MYD88 Antibody - LS-C130897 from LifeSpan Bioscience

Prices $445.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal

Anti-MYD88 Antibody (aa279-296) - LS-C309 from LifeSpan Bioscience

Prices $345.00, $1,035.00
Sizes 100 µg, 500 µg
Host Rabbit
Clonality Polyclonal
Western blot of MyD88 in Jurkat whole cell lysate with MyD88 antibody at 1:500 dilution.
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