Gene Symbol | EPHX2 |
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Entrez Gene | 2053 |
Alt Symbol | CEH, SEH |
Species | Human |
Gene Type | protein-coding |
Description | epoxide hydrolase 2, cytoplasmic |
Other Description | bifunctional epoxide hydrolase 2|epoxide hydratase|epoxide hydrolase 2, cytosolic|epoxide hydrolase, soluble |
Swissprots | J3KPH7 Q9HBJ2 Q9HBJ1 P34913 G3V134 Q16764 B3KUA0 B3KTU8 B2Z3B1 |
Accessions | ACD11487 CAA65751 EAW63547 EAW63548 EAW63549 EAW63550 EAW63551 P34913 AF233334 AAG14966 AF233335 AAG14967 AF233336 AAG14968 AK094393 AK096089 BAG53210 AK096770 BAG53362 AK294065 BAG57410 AK303904 BAG64834 AK308041 AK310507 BC007708 AAH07708 BC011628 AAH11628 BC013874 AAH13874 BQ272362 BT006885 AAP35531 BX103698 CA397329 DC331720 DQ892749 ABM83675 DQ895995 ABM86963 L05779 AAA02756 NM_001256482 NP_001243411 NM_001256483 NP_001243412 NM_001256484 NP_001243413 NM_001979 NP_001970 |
Function | Bifunctional enzyme. The C-terminal domain has epoxide hydrolase activity and acts on epoxides (alkene oxides, oxiranes) and arene oxides. Plays a role in xenobiotic metabolism by degrading potentially toxic epoxides. Also determines steady-state levels of physiological mediators. The N-terminal domain has lipid phosphatase activity, with the highest activity towards threo- 9,10-phosphonooxy-hydroxy-octadecanoic acid, followed by erythro- 9,10-phosphonooxy-hydroxy-octadecanoic acid, 12-phosphonooxy- octadec-9Z-enoic acid, 12-phosphonooxy-octadec-9E-enoic acid, and p-nitrophenyl phospate. {ECO:0000269|PubMed:12574508, ECO:0000269|PubMed:12574510}. |
Subcellular Location | Cytoplasm. Peroxisome. |
Top Pathways | Peroxisome, Arachidonic acid metabolism |
sEH (H-215) - sc-25797 from Santa Cruz Biotechnology
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sEH (Y-13) - sc-87101 from Santa Cruz Biotechnology
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sEH (A-5) - sc-166961 from Santa Cruz Biotechnology
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sEH (D-13) - sc-87099 from Santa Cruz Biotechnology
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Anti-EPHX2 antibody - ab133173 from Abcam
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Anti-EPHX2 antibody - ab185808 from Abcam
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Anti-EPHX2 antibody - ab67788 from Abcam
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Anti-EPHX2 antibody - ab117255 from Abcam
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Anti-EPHX2 antibody - ab115284 from Abcam
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Anti-EPHX2 antibody [1H5] - ab119015 from Abcam
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Anti-EPHX2 antibody [EPR10491(B)] - ab155280 from Abcam
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Anti-EPHX2 antibody - N-terminal - ab150619 from Abcam
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Anti-EPHX2 / Epoxide Hydrolase 2 Antibody (clone 2G2) - LS-C115545 from LifeSpan Bioscience
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Anti-EPHX2 / Epoxide Hydrolase 2 Antibody - LS-C311113 from LifeSpan Bioscience
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Anti-EPHX2 / Epoxide Hydrolase 2 Antibody (N-Terminus) IHC-plus⢠- LS-A8988 from LifeSpan Bioscience
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Anti-EPHX2 / Epoxide Hydrolase 2 Antibody - LS-C341369 from LifeSpan Bioscience
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Anti-EPHX2 / Epoxide Hydrolase 2 Antibody (clone 3F6) - LS-C115570 from LifeSpan Bioscience
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Anti-EPHX2 / Epoxide Hydrolase 2 Antibody IHC-plus⢠- LS-B6940 from LifeSpan Bioscience
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Anti-EPHX2 / Epoxide Hydrolase 2 Antibody (clone 2F2) - LS-C115670 from LifeSpan Bioscience
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Anti-EPHX2 / Epoxide Hydrolase 2 Antibody - LS-C331746 from LifeSpan Bioscience
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Anti-EPHX2 / Epoxide Hydrolase 2 Antibody (Internal) IHC-plus⢠- LS-A8989 from LifeSpan Bioscience
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Anti-EPHX2 / Epoxide Hydrolase 2 Antibody (C-Terminus) IHC-plus⢠- LS-A8996 from LifeSpan Bioscience
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Anti-EPHX2 / Epoxide Hydrolase 2 Antibody (clone 1A6) - LS-C115568 from LifeSpan Bioscience
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Anti-EPHX2 / Epoxide Hydrolase 2 Antibody - LS-C307410 from LifeSpan Bioscience
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EPHX2 Antibody (1A6) - NBP2-02948 from Novus Biologicals
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