Gene Symbol | NAGS |
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Entrez Gene | 162417 |
Alt Symbol | AGAS, ARGA |
Species | Human |
Gene Type | protein-coding |
Description | N-acetylglutamate synthase |
Other Description | N-acetylglutamate synthase, mitochondrial|amino-acid acetyltransferase |
Swissprots | Q8N159 Q8IWR4 B2RAZ9 |
Accessions | AAM75385 EAW51643 Q8N159 AI241153 AK074407 AK091938 AK300923 BAG62555 AK314432 BAG37046 AY116538 AAM75386 AY158070 AAN76451 BC111713 AAI11714 BF589712 XM_011524438 XP_011522740 XM_011524439 XP_011522741 NM_153006 NP_694551 |
Function | Plays a role in the regulation of ureagenesis by producing the essential cofactor N-acetylglutamate (NAG), thus modulating carbamoylphosphate synthase I (CPSI) activity. |
Subcellular Location | Mitochondrion matrix. |
Tissue Specificity | Highly expressed in the adult liver, kidney and small intestine. Weakly expressed in the fetal liver, lung, pancreas, placenta, heart and brain tissue. {ECO:0000269|PubMed:12459178, ECO:0000269|PubMed:12754705}. |
Top Pathways | Arginine and proline metabolism, Biosynthesis of amino acids, 2-Oxocarboxylic acid metabolism |
NAGS CRISPR/Cas9 KO Plasmid (h) - sc-406340 from Santa Cruz Biotechnology
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NAGS HDR Plasmid (h) - sc-406340-HDR from Santa Cruz Biotechnology
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NAGS Double Nickase Plasmid (h) - sc-406340-NIC from Santa Cruz Biotechnology
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NAGS Double Nickase Plasmid (h2) - sc-406340-NIC-2 from Santa Cruz Biotechnology
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NAGS CRISPR Activation Plasmid (h) - sc-406340-ACT from Santa Cruz Biotechnology
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NAGS CRISPR Activation Plasmid (h2) - sc-406340-ACT-2 from Santa Cruz Biotechnology
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NAGS Lentiviral Activation Particles (h) - sc-406340-LAC from Santa Cruz Biotechnology
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NAGS Lentiviral Activation Particles (h2) - sc-406340-LAC-2 from Santa Cruz Biotechnology
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NAGS siRNA (h) - sc-93810 from Santa Cruz Biotechnology
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NAGS shRNA Plasmid (h) - sc-93810-SH from Santa Cruz Biotechnology
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NAGS shRNA (h) Lentiviral Particles - sc-93810-V from Santa Cruz Biotechnology
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NAGS RNAi - H00162417-R02 from Novus Biologicals
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MISSION® esiRNA - EHU153281 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN14934 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND14934 from Sigma-Aldrich
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NAGS siRNA (Human) - CRJ5947 from Cohesion Biosciences
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shRNA set against Human NAGS (NM_153006.2) - SHH349068 from Creative biogene
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Human NAGS siRNA - orb276448 from Biorbyt
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NAGS shRNA Plasmid (Human) - CHJ5947 from Cohesion Biosciences
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NAGS miRNA 3'UTR clone - MiUTR1H-06625 from Creative biogene
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