Gene Symbol | IFNK |
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Entrez Gene | 56832 |
Alt Symbol | IFNT1, INFE1 |
Species | Human |
Gene Type | protein-coding |
Description | interferon, kappa |
Other Description | IFN-kappa|interferon kappa|interferon-like protein |
Swissprots | Q9P0W0 Q5T166 |
Accessions | AAK63835 EAW58563 Q9P0W0 AF146759 AAF67468 AF315688 AAK01623 AY358855 AAQ89214 BC140280 AAI40281 BC141647 AAI41648 NM_020124 NP_064509 |
Function | May play a role in the regulation of immune cell function. Cytokine that imparts cellular protection against viral infection in a species-specific manner. Activates the interferon- stimulated response element signaling pathway. It is able to directly modulate cytokine release from monocytes and dendritic cells. Binds heparin. {ECO:0000269|PubMed:11514542, ECO:0000269|PubMed:12391192}. |
Subcellular Location | Secreted. |
Tissue Specificity | Expressed in keratinocytes, monocytes and in resting dendritic cells. {ECO:0000269|PubMed:11514542, ECO:0000269|PubMed:12391192}. |
Top Pathways | Cytokine-cytokine receptor interaction, Jak-STAT signaling pathway, RIG-I-like receptor signaling pathway |
IFN-κ CRISPR/Cas9 KO Plasmid (h) - sc-417280 from Santa Cruz Biotechnology
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IFN-κ HDR Plasmid (h) - sc-417280-HDR from Santa Cruz Biotechnology
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IFN-κ Double Nickase Plasmid (h) - sc-417280-NIC from Santa Cruz Biotechnology
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IFN-κ Double Nickase Plasmid (h2) - sc-417280-NIC-2 from Santa Cruz Biotechnology
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IFN-κ CRISPR Activation Plasmid (h) - sc-417280-ACT from Santa Cruz Biotechnology
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IFN-κ CRISPR Activation Plasmid (h2) - sc-417280-ACT-2 from Santa Cruz Biotechnology
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IFN-κ Lentiviral Activation Particles (h) - sc-417280-LAC from Santa Cruz Biotechnology
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IFN-κ Lentiviral Activation Particles (h2) - sc-417280-LAC-2 from Santa Cruz Biotechnology
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IFN-κ siRNA (h) - sc-39608 from Santa Cruz Biotechnology
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IFN-κ shRNA Plasmid (h) - sc-39608-SH from Santa Cruz Biotechnology
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IFN-κ shRNA (h) Lentiviral Particles - sc-39608-V from Santa Cruz Biotechnology
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CompoZr® Knockout ZFN Kit - CKOZFN10495 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND10495 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR03993 from Sigma-Aldrich
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IFNK siRNA (Human) - CRJ1182 from Cohesion Biosciences
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IFN-alpha K RNAi - H00056832-R01 from Novus Biologicals
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IFNK - MBS8216127 from MyBioSource
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shRNA set against Human IFNK (NM_020124.2) - SHH317201 from Creative biogene
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shRNA set against Human IFNK(NM_020124.2) - SHL166734 from Creative biogene
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Human IFNK siRNA - orb271683 from Biorbyt
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IFNK shRNA Plasmid (Human) - CHJ1182 from Cohesion Biosciences
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IFNK miRNA 3'UTR clone - MiUTR1H-04820 from Creative biogene
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