| Gene Symbol | RSAD2 |
|---|---|
| Entrez Gene | 91543 |
| Alt Symbol | 2510004L01Rik, cig33, cig5, vig1 |
| Species | Human |
| Gene Type | protein-coding |
| Description | radical S-adenosyl methionine domain containing 2 |
| Other Description | cytomegalovirus-induced gene 5 protein|radical S-adenosyl methionine domain-containing protein 2|viperin|virus inhibitory protein, endoplasmic reticulum-associated, interferon-inducible |
| Swissprots | Q8WXG1 Q8WVI4 |
| Accessions | AAY14802 EAX01034 EAX01035 Q8WXG1 AF026942 AF442151 AAL50053 AK300085 BAG61888 AK312670 BAG35552 BC017969 AAH17969 DQ891977 ABM82903 DQ895168 ABM86094 XM_011510414 XP_011508716 XM_011510415 XP_011508717 NM_080657 NP_542388 |
| Function | Interferon-inducible iron-sulfur (4FE-4S) cluster- binding antiviral protein which plays a major role in the cell antiviral state induced by type I and type II interferon. Can inhibit a wide range of DNA and RNA viruses, including human cytomegalovirus (HCMV), hepatitis C virus (HCV), west Nile virus (WNV), dengue virus, sindbis virus, influenza A virus, sendai virus, vesicular stomatitis virus (VSV), and human immunodeficiency virus (HIV-1). Displays antiviral activity against influenza A virus by inhibiting the budding of the virus from the plasma membrane by disturbing the lipid rafts. This is accomplished, at least in part, through binding and inhibition of the enzyme farnesyl diphospate synthase (FPPS), which is essential for the biosynthesis of isoprenoid-derived lipids. Promotes TLR7 and TLR9-dependent production of IFN-beta production in plasmacytoid dendritic cells (pDCs) by facilitating Lys-63'-linked ubiquitination of IRAK1. Plays a role in CD4+ T-cells activation and differ |
| Subcellular Location | Endoplasmic reticulum membrane; Peripheral membrane protein; Cytoplasmic side. Golgi apparatus {ECO:0000269|PubMed:11752458, ECO:0000269|PubMed:16982913}. Endoplasmic reticulum {ECO:0000269|PubMed:11752458, ECO:0000269|PubMed:16982913}. Lipid droplet {ECO:0000250}. Mitochondrion. Mitochondrion inner membrane. Mitochondrion outer membrane. Note=Infection with human cytomegalovirus (HCMV) causes relocation to the Golgi apparatus and to cytoplasmic vacuoles which also contain HCMV proteins glycoprotein B and pp28. Interaction with human cytomegalovirus/HHV-5 protein vMIA/UL37 results in its relocalization from the endoplasmic reticulum to the mitochondria. |
| Top Pathways | Influenza A |