RSAD2

Gene Symbol RSAD2
Entrez Gene 91543
Alt Symbol 2510004L01Rik, cig33, cig5, vig1
Species Human
Gene Type protein-coding
Description radical S-adenosyl methionine domain containing 2
Other Description cytomegalovirus-induced gene 5 protein|radical S-adenosyl methionine domain-containing protein 2|viperin|virus inhibitory protein, endoplasmic reticulum-associated, interferon-inducible
Swissprots Q8WXG1 Q8WVI4
Accessions AAY14802 EAX01034 EAX01035 Q8WXG1 AF026942 AF442151 AAL50053 AK300085 BAG61888 AK312670 BAG35552 BC017969 AAH17969 DQ891977 ABM82903 DQ895168 ABM86094 XM_011510414 XP_011508716 XM_011510415 XP_011508717 NM_080657 NP_542388
Function Interferon-inducible iron-sulfur (4FE-4S) cluster- binding antiviral protein which plays a major role in the cell antiviral state induced by type I and type II interferon. Can inhibit a wide range of DNA and RNA viruses, including human cytomegalovirus (HCMV), hepatitis C virus (HCV), west Nile virus (WNV), dengue virus, sindbis virus, influenza A virus, sendai virus, vesicular stomatitis virus (VSV), and human immunodeficiency virus (HIV-1). Displays antiviral activity against influenza A virus by inhibiting the budding of the virus from the plasma membrane by disturbing the lipid rafts. This is accomplished, at least in part, through binding and inhibition of the enzyme farnesyl diphospate synthase (FPPS), which is essential for the biosynthesis of isoprenoid-derived lipids. Promotes TLR7 and TLR9-dependent production of IFN-beta production in plasmacytoid dendritic cells (pDCs) by facilitating Lys-63'-linked ubiquitination of IRAK1. Plays a role in CD4+ T-cells activation and differ
Subcellular Location Endoplasmic reticulum membrane; Peripheral membrane protein; Cytoplasmic side. Golgi apparatus {ECO:0000269|PubMed:11752458, ECO:0000269|PubMed:16982913}. Endoplasmic reticulum {ECO:0000269|PubMed:11752458, ECO:0000269|PubMed:16982913}. Lipid droplet {ECO:0000250}. Mitochondrion. Mitochondrion inner membrane. Mitochondrion outer membrane. Note=Infection with human cytomegalovirus (HCMV) causes relocation to the Golgi apparatus and to cytoplasmic vacuoles which also contain HCMV proteins glycoprotein B and pp28. Interaction with human cytomegalovirus/HHV-5 protein vMIA/UL37 results in its relocalization from the endoplasmic reticulum to the mitochondria.
Top Pathways Influenza A

Viperin (D5T2X) Rabbit mAb - 13996 from Cell Signaling Technology

Prices $246.00
Sizes 100 µl (10 western blots)
Host Rabbit
Clonality Monoclonal
Clone D5T2X
Western blot analysis of extracts from 293T cells, mock transfected (-) or transfected with a construct expressing DDK-tagged full-length human Viperin (hViperin-DDK; +), using viperin (D5T2X) Rabbit mAb.

RSAD2 (G-8) - sc-390342 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
RSAD2 (G-8): sc-390342. Western blot analysis of RSAD2 expression in Jurkat (A) and HUV-EC-C (B) whole cell lysates.

RSAD2 (E-13) - sc-132442 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
RSAD2 (E-13): sc-132442. Western blot analysis of RSAD2 expression in HUV-EC-C (A) and Jurkat (B) whole cell lysates.

RSAD2 (H-291) - sc-368790 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal

RSAD2 (S-12) - sc-132443 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

RSAD2 (O-24) - sc-102099 from Santa Cruz Biotechnology

Prices $279.00
Sizes 100 µg/ml
Host Rabbit
Clonality Polyclonal
RSAD2 (O-24): sc-102099. Western blot analysis of RSAD2 expression in Jurkat whole cell lysate.

Anti-Viperin antibody [4D12] - ab156788 from Abcam

Host Mouse
Clonality Monoclonal
Clone 4D12
All lanes : Anti-Viperin antibody [4D12] (ab156788) at 1/4000 dilutionLane 1 : HEK293T cells transfected with pCMV6-ENTRY controlLane 2 : HEK293T cells transfected with pCMV6-ENTRY ViperinLysates/proteins at 5 µg per lane.

Anti-Viperin antibody [MaP.VIP] - ab107359 from Abcam

Prices $373.00
Sizes 50 µg
Host Mouse
Clonality Monoclonal
Clone MaP.VIP

Anti-VIPERIN / RSAD2 Antibody (aa92-362, clone MaP.VIP) - LS-C139851 from LifeSpan Bioscience

Prices $515.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone MaP.VIP

Anti-VIPERIN / RSAD2 Antibody (aa165-215) - LS-C148858 from LifeSpan Bioscience

Prices $335.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-VIPERIN / RSAD2 Antibody (aa101-150) - LS-C31915 from LifeSpan Bioscience

Prices $325.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Jurkat Cell Lysate

Anti-VIPERIN / RSAD2 Antibody - LS-C343717 from LifeSpan Bioscience

Prices $395.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Detection of mouse Viperin in L929 cells by Western Blot using PAb to Viperin (AT131). Cell extracts from L929 cell either unstimulated (lane 1) or stimulated for 24h with poly(dA.dT) poly(dT.dA) at 3 ug/ml (lane 2) were resolved by SDS-PAGE under reducing conditions, transferred to nitrocellulose and incubated with the PAb to Viperin (AT131) at a 1:1000 dilution for 1 hour. Proteins were visualized using a peroxidase-conjugated polyclonal antibody to rabbit IgG and a chemiluminescence detection system.

Anti-VIPERIN / RSAD2 Antibody (C-Terminus) - LS-C31916 from LifeSpan Bioscience

Prices $325.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
RSAD2 / Viperin antibody LS-C31916 was used in IHC to stain formalin-fixed, paraffin-embedded human kidney.

Anti-VIPERIN / RSAD2 Antibody (clone 4D12) - LS-C174525 from LifeSpan Bioscience

Prices $350.00
Sizes 100 µl
Host Mouse
Clonality Monoclonal
Clone 4D12
Anti-RSAD2 mouse monoclonal antibody immunofluorescent staining of COS7 cells transiently transfected by pCMV6-ENTRY RSAD2.

Viperin Antibody - NBP2-03971 from Novus Biologicals

Prices $99.00, $249.00
Sizes 25 µg, 100 µg
Host Rabbit
Clonality Polyclonal
Western Blot: Viperin Antibody [NBP2-03971] - analysis of viperin using viperin polyclonal antibody. Human brain lysate in the absence (1) and presence (2) of immunizing peptide, mouse brain (3) and rat brain (4) lysate probed with viperin antibody at 3 ug/ml. Goat anti-rabbit Ig HRP secondary antibody and PicoTect ECL substrate solution were used for this test.

Viperin Antibody - NBP1-58021 from Novus Biologicals

Prices $299.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Western Blot: Viperin Antibody [NBP1-58021] - Jurkat cell lysate, Antibody Titration: 5.0ug/ml

Viperin Antibody - NBP1-58062 from Novus Biologicals

Prices $139.00, $299.00
Sizes 20 µl, 100 µl
Host Rabbit
Clonality Polyclonal
Western Blot: Viperin Antibody [NBP1-58062] - Jurkat cell lysate, concentration 2.5 ug/ml.

Viperin Antibody - NBP1-84467 from Novus Biologicals

Prices $419.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Viperin Antibody (MaP.VIP) - NBP1-49603 from Novus Biologicals

Prices $329.00
Sizes 50 µg
Host Mouse
Clonality Monoclonal
Clone MaP.VIP

Viperin Antibody (4D10) - H00091543-M01 from Novus Biologicals

Prices $359.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone 4D10
Western Blot: Viperin Antibody (4D10) [H00091543-M01] - Analysis of RSAD2 expression in transfected 293T cell line by RSAD2 monoclonal antibody (M01), clone 4D10.Lane 1: RSAD2 transfected lysate (Predicted MW: 42.2 KDa).Lane 2: Non-transfected lysate.

Viperin Antibody - H00091543-B01P from Novus Biologicals

Prices $359.00
Sizes 50 µg
Host Mouse
Clonality Polyclonal

Viperin Polyclonal Antibody - bs-8718R from Bioss

Prices $269.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Anti-RSAD2 (AB2) antibody produced in rabbit - AV42696 from Sigma-Aldrich

Prices $267.50, $267.50
Sizes 100 µg, 100 µl
Host Rabbit
Clonality Polyclonal
<B>Immunohistochemistry</B><BR/>Anti-RSAD2 (ab2): <B>Cat. No. AV42696</B>: Immunohistochemistry of RSAD2 in Human Kidney tissue with RSAD2 antibody at 4-8 μg/mL.

Anti-RSAD2 antibody produced in mouse - SAB1409978 from Sigma-Aldrich

Prices $347.00
Sizes 50 µg
Host Mouse
Clonality Polyclonal
<B>Immunoblotting</B><BR/>Anti-RSAD2: <B>Cat. No. SAB1409978</B>: Antibody concentration: 0.1-5 μg/mL. Specific band of ~39.7 kDa using RSAD2 transfected 293T lysate.<BR/><B>Lanes</B><BR/>1. Transfected 293T lysate.<BR/>2. Non-transfected 293T lysate.

Anti-RSAD2 (AB1) antibody produced in rabbit - AV42695 from Sigma-Aldrich

Prices $267.50, $267.50
Sizes 100 µg, 100 µl
Host Rabbit
Clonality Polyclonal
<B>Immunoblotting</B><BR/>Cell Type: Jurkat (<B>Cat. No. AV42695</B>).<BR/><B>Lanes</B><BR/>1. Antibody dilution (concentration) 2.5 μg/mL in cell type Jurkat
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