RSAD2

Gene Symbol	RSAD2
Entrez Gene	91543
Alt Symbol	2510004L01Rik, cig33, cig5, vig1
Species	Human
Gene Type	protein-coding
Description	radical S-adenosyl methionine domain containing 2
Other Description	cytomegalovirus-induced gene 5 protein|radical S-adenosyl methionine domain-containing protein 2|viperin|virus inhibitory protein, endoplasmic reticulum-associated, interferon-inducible
Swissprots	Q8WXG1 Q8WVI4
Accessions	AAY14802 EAX01034 EAX01035 Q8WXG1 AF026942 AF442151 AAL50053 AK300085 BAG61888 AK312670 BAG35552 BC017969 AAH17969 DQ891977 ABM82903 DQ895168 ABM86094 XM_011510414 XP_011508716 XM_011510415 XP_011508717 NM_080657 NP_542388
Function	Interferon-inducible iron-sulfur (4FE-4S) cluster- binding antiviral protein which plays a major role in the cell antiviral state induced by type I and type II interferon. Can inhibit a wide range of DNA and RNA viruses, including human cytomegalovirus (HCMV), hepatitis C virus (HCV), west Nile virus (WNV), dengue virus, sindbis virus, influenza A virus, sendai virus, vesicular stomatitis virus (VSV), and human immunodeficiency virus (HIV-1). Displays antiviral activity against influenza A virus by inhibiting the budding of the virus from the plasma membrane by disturbing the lipid rafts. This is accomplished, at least in part, through binding and inhibition of the enzyme farnesyl diphospate synthase (FPPS), which is essential for the biosynthesis of isoprenoid-derived lipids. Promotes TLR7 and TLR9-dependent production of IFN-beta production in plasmacytoid dendritic cells (pDCs) by facilitating Lys-63'-linked ubiquitination of IRAK1. Plays a role in CD4+ T-cells activation and differ
Subcellular Location	Endoplasmic reticulum membrane; Peripheral membrane protein; Cytoplasmic side. Golgi apparatus {ECO:0000269|PubMed:11752458, ECO:0000269|PubMed:16982913}. Endoplasmic reticulum {ECO:0000269|PubMed:11752458, ECO:0000269|PubMed:16982913}. Lipid droplet {ECO:0000250}. Mitochondrion. Mitochondrion inner membrane. Mitochondrion outer membrane. Note=Infection with human cytomegalovirus (HCMV) causes relocation to the Golgi apparatus and to cytoplasmic vacuoles which also contain HCMV proteins glycoprotein B and pp28. Interaction with human cytomegalovirus/HHV-5 protein vMIA/UL37 results in its relocalization from the endoplasmic reticulum to the mitochondria.
Top Pathways	Influenza A

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human Viperin full length protein - ab164861 from Abcam Category Protein Source Wheat germ Species Human

Human Viperin peptide - ab73863 from Abcam Category Peptide

Human Viperin protein fragment - ab164862 from Abcam Category Protein Source Wheat germ Species Human

Recombinant Human Viperin Protein - H00091543-P01 from Novus Biologicals Category Protein Prices $319.00 Sizes 2 µg Source Wheat Germ Species Human

Viperin Partial Recombinant Protein - H00091543-Q01 from Novus Biologicals Category Protein Prices $369.00 Sizes 10 µg Species Human

RSAD2 Blocking Peptide - 33R-7188 from Fitzgerald Category Peptide Prices $130.00 Sizes 100 µg

RSAD2 Blocking Peptide - 33R-10171 from Fitzgerald Category Peptide Prices $130.00 Sizes 100 µg

RSAD2 / CIG5 - H00091543-P01 from Acris Antibodies Category Protein Prices $310.00 Sizes 2 µg Species Human

RSAD2 / CIG5 - H00091543-Q01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Species Human

RSAD2 / CIG5 - H00091543-Q01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Species Human

RSAD2 fusion protein - Ag15174 from Proteintech Group Category Protein Prices $199.00 Sizes 50 μg Source E. coli -derived, PET28a Species Human

RSAD2 fusion protein - Ag2409 from Proteintech Group Category Protein Prices $199.00 Sizes 50 μg Source E. coli -derived, PGEX-4T Species Human

Recombinant Human RSAD2, His-tagged - RSAD2-2449H from Creative Biomart Category Protein Source E.coli Species Human

Recombinant Virus Inhibitory Protein (Viperin) - RPM762Hu01 from Uscn Life Science Inc. Category Protein Source E.coli Species Human

Recombinant Virus Inhibitory Protein (Viperin) - RPM762Hu01 from Cloud-clone Category Protein Source E.coli Species Human

Recombinant Human Radical S-adenosyl methionine domain-containing protein 2(RSAD - CSB-YP848838HU CSB-EP848838HU CSB-BP848838HU CSB-MP848838HU from Cusabio Category Protein Source Yeast or E.coli or Baculovirus or Mammalian cell Species Human

RSAD2 Protein - abx163176 from Abbexa Category Protein Species Human

RSAD2 / CIG5 - TP305066 from Acris Antibodies Category Protein Prices $680.00 Sizes 20 µg Source HEK293 cells Species Human

Viperin Recombinant Protein Antigen - NBP1-84467PEP from Novus Biologicals Category Protein Prices $199.00 Sizes 100 µl Source E.coli Species Human

RSAD2 Peptide, Human - M34GP13640H from Creative Peptides Category Peptide Source Synthetic. Species Human

Viperin Recombinant Protein Antigen - NBP2-58186PEP from Novus Biologicals Category Protein Prices $199.00 Sizes 100 µl Source E.coli Species Human

Radical S-adenosyl methionine domain-containing protein 2 (RSAD2), Recombinant Protein - MBS1394421 from MyBioSource Category Protein Prices $1,125.00, $1,125.00, $1,355.00, $1,355.00, $1,790.00, $1,790.00, $2,255.00, $2,255.00 Sizes 500 µg (E-Coli), 50 µg (Baculovirus), 500 µg (Yeast), 50 µg (Mammalian-Cell), 1 mg (E-Coli), 100 µg (Baculovirus), 1 mg (Yeast), 100 µg (Mammalian-Cell) Source E Coli or Yeast or Baculovirus or Mammalian Cell Species Human

RSAD2 fusion protein - Ag27733 from Proteintech Group Category Protein Source E. coli -derived, PET28a Species Human

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