| Gene Symbol |
ABCC3
|
| Entrez Gene |
8714
|
| Alt Symbol |
ABC31, EST90757, MLP2, MOAT-D, MRP3, cMOAT2
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
ATP-binding cassette, sub-family C (CFTR/MRP), member 3
|
| Other Description |
ATP-binding cassette sub-family C member 3|canalicular multispecific organic anion transporter 2|canicular multispecific organic anion transporter|multi-specific organic anion transporter D|multidrug resistance associated protein|multidrug resistance-associated protein 3
|
| Swissprots |
O95078 O15438 O95289 B2RPA9 Q86X85 D3DTX9 O95290 O75621 Q9UN52 O60265 O60922
|
| Accessions |
CAC69553 EAW94590 EAW94591 EAW94592 EAW94593 EAW94594 O15438 AB010887 BAA28146 AB208954 BAD92191 AF009670 AAD01430 AF083552 AAC34668 AF085690 AAD02845 AF085691 AAD02846 AF085692 AAD02847 AF104943 AAD04170 AF154001 AAD38185 BC034683 BC046126 AAH46126 BC050370 AAH50370 BC058907 BC104952 AAI04953 BC127655 BC131755 BC137347 AAI37348 BC137348 AAI37349 BX649137 U66674 U83659 AAB71756 Y17151 CAA76658 XM_005257763 XP_005257820 XM_011525422 XP_011523724 XM_011525423 XP_011523725 XM_011525424 XP_011523726 XM_011525425 XP_011523727 XR_934586 NM_001144070 NP_001137542 NM_003786 NP_003777 NM_020037 NM_020038
|
| Function |
May act as an inducible transporter in the biliary and intestinal excretion of organic anions. Acts as an alternative route for the export of bile acids and glucuronides from cholestatic hepatocytes (By similarity). {ECO:0000250}.
|
| Subcellular Location |
Membrane; Multi-pass membrane protein.
|
| Tissue Specificity |
Mainly expressed in the liver. Also expressed in small intestine, colon, prostate, testis, brain and at a lower level in the kidney.
|
| Top Pathways |
ABC transporters, Bile secretion
|
![Western Blot: MRP3 Overexpression Lysate (Adult Normal) [NBL1-07178] Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for MRP3.](http://www.bioprodhub.com/system/product_images/cel_products/5/sub_1/11946_MRP3%2520Overexpression%2520Lysate%2520%2528Adult%2520Normal%2529-Western%2520Blot-NBL1-07178-img0002.jpg)