ABCC3

Gene Symbol ABCC3
Entrez Gene 8714
Alt Symbol ABC31, EST90757, MLP2, MOAT-D, MRP3, cMOAT2
Species Human
Gene Type protein-coding
Description ATP-binding cassette, sub-family C (CFTR/MRP), member 3
Other Description ATP-binding cassette sub-family C member 3|canalicular multispecific organic anion transporter 2|canicular multispecific organic anion transporter|multi-specific organic anion transporter D|multidrug resistance associated protein|multidrug resistance-associated protein 3
Swissprots O95078 O15438 O95289 B2RPA9 Q86X85 D3DTX9 O95290 O75621 Q9UN52 O60265 O60922
Accessions CAC69553 EAW94590 EAW94591 EAW94592 EAW94593 EAW94594 O15438 AB010887 BAA28146 AB208954 BAD92191 AF009670 AAD01430 AF083552 AAC34668 AF085690 AAD02845 AF085691 AAD02846 AF085692 AAD02847 AF104943 AAD04170 AF154001 AAD38185 BC034683 BC046126 AAH46126 BC050370 AAH50370 BC058907 BC104952 AAI04953 BC127655 BC131755 BC137347 AAI37348 BC137348 AAI37349 BX649137 U66674 U83659 AAB71756 Y17151 CAA76658 XM_005257763 XP_005257820 XM_011525422 XP_011523724 XM_011525423 XP_011523725 XM_011525424 XP_011523726 XM_011525425 XP_011523727 XR_934586 NM_001144070 NP_001137542 NM_003786 NP_003777 NM_020037 NM_020038
Function May act as an inducible transporter in the biliary and intestinal excretion of organic anions. Acts as an alternative route for the export of bile acids and glucuronides from cholestatic hepatocytes (By similarity). {ECO:0000250}.
Subcellular Location Membrane; Multi-pass membrane protein.
Tissue Specificity Mainly expressed in the liver. Also expressed in small intestine, colon, prostate, testis, brain and at a lower level in the kidney.
Top Pathways ABC transporters, Bile secretion

MRP3/ABCC3 (D1W1P) Rabbit mAb - 14182 from Cell Signaling Technology

Prices $246.00
Sizes 100 µl (10 western blots)
Host Rabbit
Clonality Monoclonal
Clone D1W1P
Western blot analysis of extracts from Hep G2 cells and human liver using MRP3/ABCC3 (D1W1P) Rabbit mAb.

MRP3 (C-18) - sc-5776 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
MRP3 (C-18): sc-5776. Western blot analysis of MRP3 expression in MIA PaCa-2 (A) and COLO 320DM (B) whole cell lysates.

MRP3 (D-15) - sc-5775 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

MRP3 (H-150) - sc-20767 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal

MRP3 (H-16) - sc-5774 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
MRP3 (H-16): sc-5774. Immunoperoxidase staining of formalin fixed, paraffin-embedded human gall bladder tissue showing membrane and cytoplasmic staining of glandular cells.

MRP3 (M3II-21) - sc-59612 from Santa Cruz Biotechnology

Prices $279.00
Sizes 500 µl supernatant
Host Mouse
Clonality Monoclonal

Anti-MRP3 antibody - ab198258 from Abcam

Prices $376.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Immunohistochemical analysis of paraffin-embedded Human breast cancer tissue labeling MRP3 using ab198258 at 1/20 dilution.

Anti-MRP3 antibody - ab107083 from Abcam

Prices $376.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
Anti-MRP3 antibody (ab107083) at 1/100 dilution + MDA-MB435 cell line lysates at 35 µg

Anti-MRP3 antibody - ab84887 from Abcam

Prices $376.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Anti-MRP3 antibody (ab84887) at 1 µg/ml (in 5% skim milk / PBS buffer) + MCF7 cell lysate at 10 µgSecondaryHRP conjugated anti-Rabbit IgG at 1/50000 dilution

Anti-MRP3 antibody - ab174681 from Abcam

Prices $370.00
Sizes 200 µl
Host Goat
Clonality Polyclonal

Anti-MRP3 antibody [DTX1] - ab49479 from Abcam

Prices $388.00
Sizes 100 µl
Host Mouse
Clonality Monoclonal
Clone DTX1
ab49479 staining MRP3 in rat liver tissue section by Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections). Tissue underwent formaldehyde fixation before microwave antigen retrieval and then blocking with 10% serum for 20 minutes at 25°C was performed. The primary antibody was diluted at 1/300 and incubated with sample in PBS for 48 hours at 4°C. A Biotin conjugated rabbit polyclonal to mouse IgG was used undiluted as secondary antibody.See Abreview

Anti-MRP3 antibody [M3II-21] - ab3376 from Abcam

Prices $378.00
Sizes 250 µl
Host Mouse
Clonality Monoclonal
Clone M3II-21

Anti-MRP3 antibody [M3II-9] - ab3375 from Abcam

Prices $388.00
Sizes 250 µl
Host Mouse
Clonality Monoclonal
Clone M3II-9
developed using the ECL techniquePerformed under reducing conditions.Exposure time : 20 minutes HepG2 cells were incubated at 37°C for 24h with vehicle control (0 μM) and different concentrations of clotrimazole (ab120744) in DMSO. Increased expression of MRP3 (ab3375) correlates with an increase in clotrimazole concentration, as described in literature.Whole cell lysates were prepared with RIPA buffer (containing protease inhibitors and sodium orthovanadate), 20μg of each were loaded on the gel and the WB was run under reducing conditions. After transfer the membrane was blocked for an hour using 3% milk before being incubated with ab3375 at 1/50 dilution and ab9484 at 1 μg /ml overnight at 4°C. Antibody binding was detected using an anti-mouse antibody conjugated to HRP (ab97040) at 1/10000 dilution and visualised using ECL development solution.

Anti-ABCC3 / MRP3 Antibody (aa881-894) - LS-C186434 from LifeSpan Bioscience

Prices $335.00
Sizes 100 µg
Host Goat
Clonality Polyclonal

Anti-ABCC3 / MRP3 Antibody (clone M3II-9) - LS-C202616 from LifeSpan Bioscience

Prices $325.00
Sizes 1 ml
Host Mouse
Clonality Monoclonal
Clone M3II-9

Anti-ABCC3 / MRP3 Antibody (aa899-925, Biotin) - LS-C212568 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-ABCC3 / MRP3 Antibody (aa899-925, APC) - LS-C212567 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-ABCC3 / MRP3 Antibody (clone M3II-21) - LS-C202617 from LifeSpan Bioscience

Prices $325.00
Sizes 1 ml
Host Mouse
Clonality Monoclonal
Clone M3II-21

Anti-ABCC3 / MRP3 Antibody (aa899-925, AP) - LS-C212569 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-ABCC3 / MRP3 Antibody (aa899-925, Azide-free, HRP) - LS-C212571 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-ABCC3 / MRP3 Antibody (aa684-733) - LS-C102044 from LifeSpan Bioscience

Prices $365.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
ABCC3 / MRP3 antibody LS-C102044 Western blot of MCF7 cell lysate.

Anti-ABCC3 / MRP3 Antibody (aa899-925, PE) - LS-C212574 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-ABCC3 / MRP3 Antibody (aa899-925, FITC) - LS-C212570 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-ABCC3 / MRP3 Antibody (aa906-933) - LS-C319241 from LifeSpan Bioscience

Prices $345.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-ABCC3 / MRP3 Antibody (aa971-1020) - LS-C291297 from LifeSpan Bioscience

Prices $315.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Search more