Gene Symbol | EIF2A |
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Entrez Gene | 83939 |
Alt Symbol | CDA02, EIF-2A, MST089, MSTP004, MSTP089 |
Species | Human |
Gene Type | protein-coding |
Description | eukaryotic translation initiation factor 2A, 65kDa |
Other Description | 65 kDa eukaryotic translation initiation factor 2A|eukaryotic translation initiation factor 2A |
Swissprots | A8MPS6 B4DF96 B4DQ14 Q96EW9 Q7Z4E9 Q5QTR2 Q8NFM1 Q9BY44 Q96K81 D3DNI9 |
Accessions | EAW78830 EAW78831 EAW78832 Q9BY44 AF109358 AAQ13506 AF172818 AAQ13612 AF212241 AAK14926 AF497978 AAM83402 AI560242 AK027356 BAB55058 AK293993 BAG57357 AK298586 BAG60776 AL833101 BC011885 AAH11885 BX647951 DQ896788 ABM87787 EU176412 ABW03863 XM_011513223 XP_011511525 XM_011513224 XP_011511526 NM_032025 NP_114414 |
Function | Functions in the early steps of protein synthesis of a small number of specific mRNAs. Acts by directing the binding of methionyl-tRNAi to 40S ribosomal subunits. In contrast to the eIF- 2 complex, it binds methionyl-tRNAi to 40 S subunits in a codon- dependent manner, whereas the eIF-2 complex binds methionyl-tRNAi to 40 S subunits in a GTP-dependent manner. May act by impiging the expression of specific proteins. {ECO:0000269|PubMed:12133843}. |
Tissue Specificity | Widely expressed. Expressed at higher level in pancreas, heart, brain and placenta. {ECO:0000269|PubMed:12133843}. |
eIF2A CRISPR/Cas9 KO Plasmid (h) - sc-413527 from Santa Cruz Biotechnology
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eIF2A HDR Plasmid (h) - sc-413527-HDR from Santa Cruz Biotechnology
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eIF2A Double Nickase Plasmid (h) - sc-413527-NIC from Santa Cruz Biotechnology
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eIF2A Double Nickase Plasmid (h2) - sc-413527-NIC-2 from Santa Cruz Biotechnology
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eIF2A CRISPR Activation Plasmid (h) - sc-413527-ACT from Santa Cruz Biotechnology
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eIF2A CRISPR Activation Plasmid (h2) - sc-413527-ACT-2 from Santa Cruz Biotechnology
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eIF2A Lentiviral Activation Particles (h) - sc-413527-LAC from Santa Cruz Biotechnology
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eIF2A Lentiviral Activation Particles (h2) - sc-413527-LAC-2 from Santa Cruz Biotechnology
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eIF2A siRNA (h) - sc-78173 from Santa Cruz Biotechnology
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eIF2A shRNA Plasmid (h) - sc-78173-SH from Santa Cruz Biotechnology
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eIF2A shRNA (h) Lentiviral Particles - sc-78173-V from Santa Cruz Biotechnology
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MISSION® esiRNA - EHU052871 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN7740 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND7740 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR10890 from Sigma-Aldrich
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EIF2A siRNA (Human) - CRJ3247 from Cohesion Biosciences
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eIF2A RNAi - H00083939-R01 from Novus Biologicals
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EIF2A - MBS8239638 from MyBioSource
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shRNA set against Human EIF2A (NM_032025.3) - SHH284193 from Creative biogene
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shRNA set against Human EIF2A(NM_032025.3) - SHH028343 from Creative biogene
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Human EIF2A siRNA - orb273748 from Biorbyt
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EIF2A shRNA Plasmid (Human) - CHJ3247 from Cohesion Biosciences
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EIF2A miRNA 3'UTR clone - MiUTR1H-03154 from Creative biogene
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