Gene Symbol | NSMAF |
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Entrez Gene | 8439 |
Alt Symbol | FAN |
Species | Human |
Gene Type | protein-coding |
Description | neutral sphingomyelinase (N-SMase) activation associated factor |
Other Description | factor associated with N-SMase activation|factor associated with neutral sphingomyelinase activation|protein FAN |
Swissprots | E9PCH0 B4DFB0 Q92636 Q8IW26 |
Accessions | EAW86817 Q92636 AK292679 BAF85368 AK294009 BAG57371 AK313991 BAG36703 BC041124 AAH41124 DR005814 X96586 CAA65405 NM_001144772 NP_001138244 NM_003580 NP_003571 |
Function | Couples the p55 TNF-receptor (TNF-R55 / TNFR1) to neutral sphingomyelinase (N-SMASE). Specifically binds to the N- smase activation domain of TNF-R55. May regulate ceramide production by N-SMASE. |
Tissue Specificity | Ubiquitous. |
Top Pathways | Sphingolipid signaling pathway |
FAN CRISPR/Cas9 KO Plasmid (h) - sc-411175 from Santa Cruz Biotechnology
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FAN HDR Plasmid (h) - sc-411175-HDR from Santa Cruz Biotechnology
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FAN Double Nickase Plasmid (h) - sc-411175-NIC from Santa Cruz Biotechnology
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FAN Double Nickase Plasmid (h2) - sc-411175-NIC-2 from Santa Cruz Biotechnology
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FAN CRISPR Activation Plasmid (h) - sc-411175-ACT from Santa Cruz Biotechnology
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FAN CRISPR Activation Plasmid (h2) - sc-411175-ACT-2 from Santa Cruz Biotechnology
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FAN Lentiviral Activation Particles (h) - sc-411175-LAC from Santa Cruz Biotechnology
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FAN Lentiviral Activation Particles (h2) - sc-411175-LAC-2 from Santa Cruz Biotechnology
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FAN siRNA (h) - sc-63326 from Santa Cruz Biotechnology
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FAN shRNA Plasmid (h) - sc-63326-SH from Santa Cruz Biotechnology
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FAN shRNA (h) Lentiviral Particles - sc-63326-V from Santa Cruz Biotechnology
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NSMAF RNAi - H00008439-R01 from Novus Biologicals
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MISSION® esiRNA - EHU038331 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN15534 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND15534 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR07252 from Sigma-Aldrich
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NSMAF siRNA (Human) - CRH5529 from Cohesion Biosciences
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shRNA set against Human NSMAF (NM_003580.3) - SHH355380 from Creative biogene
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NSMAF shRNA Plasmid (Human) - CHH5529 from Cohesion Biosciences
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NSMAF miRNA 3'UTR clone - MiUTR3H-05580 from Creative biogene
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NSMAF miRNA 3'UTR clone - MiUTR3H-05581 from Creative biogene
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