| Gene Symbol |
GAP43
|
| Entrez Gene |
2596
|
| Alt Symbol |
B-50, PP46
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
growth associated protein 43
|
| Other Description |
axonal membrane protein GAP-43|calmodulin-binding protein P-57|growth-associated protein 43|nerve growth-related peptide GAP43|neural phosphoprotein B-50|neuromodulin|neuron growth-associated protein 43|protein F1
|
| Swissprots |
A8K0Y4 P17677
|
| Accessions |
AAB28649 AAV88094 CAA59050 EAW79594 P17677 AF279774 AK123311 AK289699 BAF82388 AK290100 BAF82789 AK313658 BAG36412 AM392759 CAL37637 AM393509 CAL38386 BC007936 AAH07936 BT019771 AAV38576 BT019810 AAV38613 BX648458 DA701390 DQ893244 ABM84170 DQ896574 ABM87573 M25667 AAA52516 NM_001130064 NP_001123536 NM_002045 NP_002036
|
| Function |
This protein is associated with nerve growth. It is a major component of the motile "growth cones" that form the tips of elongating axons. Plays a role in axonal and dendritic filopodia induction. {ECO:0000269|PubMed:14978216, ECO:0000269|PubMed:21152083}.
|
| Subcellular Location |
Cell membrane {ECO:0000269|PubMed:14978216}; Peripheral membrane protein {ECO:0000269|PubMed:14978216}; Cytoplasmic side {ECO:0000269|PubMed:14978216}. Cell projection, growth cone membrane {ECO:0000269|PubMed:14978216}; Peripheral membrane protein {ECO:0000269|PubMed:14978216}; Cytoplasmic side {ECO:0000269|PubMed:14978216}. Cell junction, synapse {ECO:0000269|PubMed:14978216}. Cell projection, filopodium membrane {ECO:0000269|PubMed:14978216}; Peripheral membrane protein {ECO:0000269|PubMed:14978216}. Note=Cytoplasmic surface of growth cone and synaptic plasma membranes.
|