Gene Symbol | MTPN |
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Entrez Gene | 136319 |
Alt Symbol | GCDP, V-1 |
Species | Human |
Gene Type | protein-coding |
Description | myotrophin |
Other Description | granule cell differentiation protein|protein V-1 |
Swissprots | P58546 |
Accessions | EAL24056 EAW83859 EAW83860 P58546 AF106075 AAP97226 AK055660 AK056225 BAG51651 AK309816 AL110137 AL834231 CAD38909 AM393216 CAL38094 AM393266 CAL38144 AY611627 AAU14892 BC028093 AAH28093 BC034722 CB530008 DA325130 NM_145808 NP_665807 |
Function | Promotes dimerization of NF-kappa-B subunits and regulates NF-kappa-B transcription factor activity (By similarity). Plays a role in the regulation of the growth of actin filaments. Inhibits the activity of the F-actin-capping protein complex formed by the CAPZA1 and CAPZB heterodimer. Promotes growth of cardiomyocytes, but not cardiomyocyte proliferation. Promotes cardiac muscle hypertrophy. {ECO:0000250, ECO:0000269|PubMed:10329199, ECO:0000269|PubMed:16895918, ECO:0000269|PubMed:20625546}. |
Subcellular Location | Cytoplasm {ECO:0000305}. Nucleus {ECO:0000250}. Cytoplasm, perinuclear region {ECO:0000250}. |
Tissue Specificity | Ubiquitous. {ECO:0000269|PubMed:10329199}. |
Myotrophin CRISPR/Cas9 KO Plasmid (h) - sc-406148 from Santa Cruz Biotechnology
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Myotrophin HDR Plasmid (h) - sc-406148-HDR from Santa Cruz Biotechnology
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Myotrophin Double Nickase Plasmid (h) - sc-406148-NIC from Santa Cruz Biotechnology
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Myotrophin Double Nickase Plasmid (h2) - sc-406148-NIC-2 from Santa Cruz Biotechnology
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Myotrophin CRISPR Activation Plasmid (h) - sc-406148-ACT from Santa Cruz Biotechnology
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Myotrophin CRISPR Activation Plasmid (h2) - sc-406148-ACT-2 from Santa Cruz Biotechnology
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Myotrophin Lentiviral Activation Particles (h) - sc-406148-LAC from Santa Cruz Biotechnology
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Myotrophin Lentiviral Activation Particles (h2) - sc-406148-LAC-2 from Santa Cruz Biotechnology
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Myotrophin siRNA (h) - sc-45700 from Santa Cruz Biotechnology
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Myotrophin shRNA Plasmid (h) - sc-45700-SH from Santa Cruz Biotechnology
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Myotrophin shRNA (h) Lentiviral Particles - sc-45700-V from Santa Cruz Biotechnology
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Myotrophin RNAi - H00136319-R01 from Novus Biologicals
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MISSION® esiRNA - EHU088481 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN14729 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND14729 from Sigma-Aldrich
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MTPN siRNA (Human) - CRJ5186 from Cohesion Biosciences
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shRNA set against Human MTPN (NM_145808.3) - SHH346632 from Creative biogene
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Human MTPN siRNA - orb275687 from Biorbyt
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MTPN shRNA Plasmid (Human) - CHJ5186 from Cohesion Biosciences
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MTPN miRNA 3'UTR clone - MiUTR4H-TG05720 from Creative biogene
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