| Gene Symbol |
Dio2
|
| Entrez Gene |
13371
|
| Alt Symbol |
5DII, AI324267, DIOII
|
| Species |
Mouse
|
| Gene Type |
protein-coding
|
| Description |
deiodinase, iodothyronine, type II
|
| Other Description |
iodothyronine type II deiodinase|type 2 DI|type II iodothyronine deiodinase|type-II 5' deiodinase|type-II 5'-deiodinase
|
| Swissprots |
Q9JHH1 Q9Z1Y9 Q05A70
|
| Accessions |
EDL18957 Q9Z1Y9 AF093137 AAF00069 AF096875 AAD11422 AF177196 AAD53113 AF177197 AAD53114 AK032038 AK045607 BC125383 AAI25384 BC125385 AAI25386 BE655410 CB522312 CO042302 CO425270 CO427407 CV555526 CX223140 NM_010050 NP_034180
|
| Function |
Responsible for the deiodination of T4 (3,5,3',5'- tetraiodothyronine) into T3 (3,5,3'-triiodothyronine). Essential for providing the brain with appropriate levels of T3 during the critical period of development (By similarity). {ECO:0000250}.
|
| Subcellular Location |
Membrane {ECO:0000305}; Single-pass membrane protein {ECO:0000305}.
|
| Tissue Specificity |
Expressed in mammary gland and in brain. {ECO:0000269|PubMed:10715551}.
|