Gene Symbol | Dio2 |
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Entrez Gene | 13371 |
Alt Symbol | 5DII, AI324267, DIOII |
Species | Mouse |
Gene Type | protein-coding |
Description | deiodinase, iodothyronine, type II |
Other Description | iodothyronine type II deiodinase|type 2 DI|type II iodothyronine deiodinase|type-II 5' deiodinase|type-II 5'-deiodinase |
Swissprots | Q9JHH1 Q9Z1Y9 Q05A70 |
Accessions | EDL18957 Q9Z1Y9 AF093137 AAF00069 AF096875 AAD11422 AF177196 AAD53113 AF177197 AAD53114 AK032038 AK045607 BC125383 AAI25384 BC125385 AAI25386 BE655410 CB522312 CO042302 CO425270 CO427407 CV555526 CX223140 NM_010050 NP_034180 |
Function | Responsible for the deiodination of T4 (3,5,3',5'- tetraiodothyronine) into T3 (3,5,3'-triiodothyronine). Essential for providing the brain with appropriate levels of T3 during the critical period of development (By similarity). {ECO:0000250}. |
Subcellular Location | Membrane {ECO:0000305}; Single-pass membrane protein {ECO:0000305}. |
Tissue Specificity | Expressed in mammary gland and in brain. {ECO:0000269|PubMed:10715551}. |
DIO2 CRISPR/Cas9 KO Plasmid (m) - sc-420003 from Santa Cruz Biotechnology
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DIO2 HDR Plasmid (m) - sc-420003-HDR from Santa Cruz Biotechnology
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DIO2 Double Nickase Plasmid (m) - sc-420003-NIC from Santa Cruz Biotechnology
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DIO2 Double Nickase Plasmid (m2) - sc-420003-NIC-2 from Santa Cruz Biotechnology
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DIO2 CRISPR Activation Plasmid (m) - sc-420003-ACT from Santa Cruz Biotechnology
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DIO2 CRISPR Activation Plasmid (m2) - sc-420003-ACT-2 from Santa Cruz Biotechnology
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DIO2 Lentiviral Activation Particles (m) - sc-420003-LAC from Santa Cruz Biotechnology
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DIO2 Lentiviral Activation Particles (m2) - sc-420003-LAC-2 from Santa Cruz Biotechnology
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DIO2 siRNA (m) - sc-77149 from Santa Cruz Biotechnology
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DIO2 shRNA Plasmid (m) - sc-77149-SH from Santa Cruz Biotechnology
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DIO2 shRNA (m) Lentiviral Particles - sc-77149-V from Santa Cruz Biotechnology
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CompoZr® Knockout ZFN Kit - CKOZFN29999 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND29999 from Sigma-Aldrich
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DIO2 siRNA (Mouse) - CRM1030 from Cohesion Biosciences
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DIO2 - MBS8215560 from MyBioSource
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shRNA set against Mouse DIO2 (NM_010050.2) - SHH278125 from Creative biogene
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shRNA set against Mouse Dio2(NM_010050.2) - SHH005609 from Creative biogene
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Mouse DIO2 siRNA - orb280506 from Biorbyt
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DIO2 shRNA Plasmid (Mouse) - CHM1030 from Cohesion Biosciences
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DIO2 miRNA 3'UTR clone - MiUTR1M-03867 from Creative biogene
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