| Gene Symbol |
SLC25A24
|
| Entrez Gene |
29957
|
| Alt Symbol |
APC1, SCAMC-1
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
solute carrier family 25 (mitochondrial carrier; phosphate carrier), member 24
|
| Other Description |
calcium-binding mitochondrial carrier protein SCaMC-1|calcium-binding transporter|mitochondrial ATP-Mg/Pi carrier protein 1|mitochondrial Ca(2+)-dependent solute carrier protein 1|short calcium-binding mitochondrial carrier 1|small calcium-binding mitochondrial carrier protein 1
|
| Swissprots |
Q6PJJ9 Q705K4 Q9P129 Q5T485 Q6NUK1 B7ZAI9 Q5T331
|
| Accessions |
EAW51254 EAW51255 Q6NUK1 AF123303 AAF28888 AJ619961 CAF04058 AJ619987 CAF04493 AK292567 BAF85256 AK304165 BAG65052 AK316304 BAH14675 AK316506 BAH14877 AL050209 AW069035 BC014519 AAH14519 BC029377 BC029905 BC068010 BC068561 AAH68561 BE243559 BQ685792 DC309482 DC340944 DC416591 EU832524 ACE87696 EU832606 ACE87008 NM_013386 NP_037518 NM_213651 NP_998816
|
| Function |
Calcium-dependent mitochondrial solute carrier. Mediates the reversible, electroneutral exchange of Mg-ATP or Mg-ADP against phosphate ions, catalyzing the net uptake or efflux of adenine nucleotides across the mitochondrial inner membrane. Nucleotide transport is inactive when cytosolic calcium levels are low, and is activated by an increase in cytosolic calcium levels. May play a role in protecting cells against oxidative stress- induced cell death, probably by promoting the formation of calcium-phosphate precipitates in the mitochondrial matrix, and thereby buffering calcium levels in the mitochondrial matrix. {ECO:0000269|PubMed:15123600, ECO:0000269|PubMed:22015608}.
|
| Subcellular Location |
Mitochondrion inner membrane {ECO:0000269|PubMed:15054102, ECO:0000269|PubMed:15123600, ECO:0000269|PubMed:22015608}; Multi-pass membrane protein {ECO:0000269|PubMed:15054102, ECO:0000269|PubMed:15123600, ECO:0000269|PubMed:22015608}.
|
| Tissue Specificity |
Present in various cell lines (at protein level). Expressed in all tissues tested. Highly expressed in testis, expressed at intermediate level in small intestine and pancreas, and weakly expressed in kidney, spleen, liver, skeletal muscle and heart. {ECO:0000269|PubMed:15054102, ECO:0000269|PubMed:15123600}.
|
![Western Blot: SLC25A24 Overexpression Lysate (Adult Normal) [NBP2-04468] Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for SLC25A24.](http://www.bioprodhub.com/system/product_images/cel_products/5/sub_2/4132_SLC25A24%2520Overexpression%2520Lysate%2520(Adult%2520Normal)-Western%2520Blot-NBP2-04468-img0001.jpg)