Gene Symbol | SLC25A24 |
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Entrez Gene | 29957 |
Alt Symbol | APC1, SCAMC-1 |
Species | Human |
Gene Type | protein-coding |
Description | solute carrier family 25 (mitochondrial carrier; phosphate carrier), member 24 |
Other Description | calcium-binding mitochondrial carrier protein SCaMC-1|calcium-binding transporter|mitochondrial ATP-Mg/Pi carrier protein 1|mitochondrial Ca(2+)-dependent solute carrier protein 1|short calcium-binding mitochondrial carrier 1|small calcium-binding mitochondrial carrier protein 1 |
Swissprots | Q6PJJ9 Q705K4 Q9P129 Q5T485 Q6NUK1 B7ZAI9 Q5T331 |
Accessions | EAW51254 EAW51255 Q6NUK1 AF123303 AAF28888 AJ619961 CAF04058 AJ619987 CAF04493 AK292567 BAF85256 AK304165 BAG65052 AK316304 BAH14675 AK316506 BAH14877 AL050209 AW069035 BC014519 AAH14519 BC029377 BC029905 BC068010 BC068561 AAH68561 BE243559 BQ685792 DC309482 DC340944 DC416591 EU832524 ACE87696 EU832606 ACE87008 NM_013386 NP_037518 NM_213651 NP_998816 |
Function | Calcium-dependent mitochondrial solute carrier. Mediates the reversible, electroneutral exchange of Mg-ATP or Mg-ADP against phosphate ions, catalyzing the net uptake or efflux of adenine nucleotides across the mitochondrial inner membrane. Nucleotide transport is inactive when cytosolic calcium levels are low, and is activated by an increase in cytosolic calcium levels. May play a role in protecting cells against oxidative stress- induced cell death, probably by promoting the formation of calcium-phosphate precipitates in the mitochondrial matrix, and thereby buffering calcium levels in the mitochondrial matrix. {ECO:0000269|PubMed:15123600, ECO:0000269|PubMed:22015608}. |
Subcellular Location | Mitochondrion inner membrane {ECO:0000269|PubMed:15054102, ECO:0000269|PubMed:15123600, ECO:0000269|PubMed:22015608}; Multi-pass membrane protein {ECO:0000269|PubMed:15054102, ECO:0000269|PubMed:15123600, ECO:0000269|PubMed:22015608}. |
Tissue Specificity | Present in various cell lines (at protein level). Expressed in all tissues tested. Highly expressed in testis, expressed at intermediate level in small intestine and pancreas, and weakly expressed in kidney, spleen, liver, skeletal muscle and heart. {ECO:0000269|PubMed:15054102, ECO:0000269|PubMed:15123600}. |
SCaMC-1 CRISPR/Cas9 KO Plasmid (h) - sc-408440 from Santa Cruz Biotechnology
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SCaMC-1 HDR Plasmid (h) - sc-408440-HDR from Santa Cruz Biotechnology
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SCaMC-1 Double Nickase Plasmid (h) - sc-408440-NIC from Santa Cruz Biotechnology
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SCaMC-1 Double Nickase Plasmid (h2) - sc-408440-NIC-2 from Santa Cruz Biotechnology
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SCaMC-1 CRISPR Activation Plasmid (h) - sc-408440-ACT from Santa Cruz Biotechnology
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SCaMC-1 CRISPR Activation Plasmid (h2) - sc-408440-ACT-2 from Santa Cruz Biotechnology
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SCaMC-1 Lentiviral Activation Particles (h) - sc-408440-LAC from Santa Cruz Biotechnology
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SCaMC-1 Lentiviral Activation Particles (h2) - sc-408440-LAC-2 from Santa Cruz Biotechnology
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SCaMC-1 siRNA (h) - sc-88209 from Santa Cruz Biotechnology
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SCaMC-1 shRNA Plasmid (h) - sc-88209-SH from Santa Cruz Biotechnology
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SCaMC-1 shRNA (h) Lentiviral Particles - sc-88209-V from Santa Cruz Biotechnology
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SLC25A24 RNAi - H00029957-R01 from Novus Biologicals
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MISSION® esiRNA - EHU085281 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN19493 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND19493 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR12803 from Sigma-Aldrich
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SLC25A24 siRNA (Human) - CRH9298 from Cohesion Biosciences
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SLC25A24 RNAi - H00029957-R02 from Novus Biologicals
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SLC25A24 - MBS8202058 from MyBioSource
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shRNA set against Human SLC25A24 (NM_013386.4) - SHH409572 from Creative biogene
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Human SLC25A24 siRNA - orb269800 from Biorbyt
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SLC25A24 shRNA Plasmid (Human) - CHH9298 from Cohesion Biosciences
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SLC25A24 miRNA 3'UTR clone - MiUTR3H-10190 from Creative biogene
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SLC25A24 miRNA 3'UTR clone - MiUTR3H-10191 from Creative biogene
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