| Gene Symbol |
ATAT1
|
| Entrez Gene |
79969
|
| Alt Symbol |
C6orf134, MEC17, Nbla00487, TAT
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
alpha tubulin acetyltransferase 1
|
| Other Description |
TAT|acetyltransferase mec-17 homolog|alpha-TAT|alpha-TAT1|alpha-tubulin N-acetyltransferase 1
|
| Swissprots |
Q9BRS1 Q8NDK9 Q3LIB0 Q5SQI0 Q86X42 Q5SQI1 Q5JP39 Q9H8X5 A2AB28 Q5SU03 Q5JP40 Q5JP42
|
| Accessions |
EAX03306 EAX03307 EAX03308 EAX03309 Q5SQI0 AB075512 BAE45758 AK023220 BAB14472 AK225107 AK297661 BAH12643 AK298743 BAH12864 AL535697 AL833858 CAD38717 BC006105 AAH06105 BC025755 AAH25755 BC047303 AAH47303 BX418089 BX418559 BX442806 CX786272 DB090032 XM_005249414 XP_005249471 XM_005249415 XP_005249472 XM_005249416 XP_005249473 XM_005249417 XP_005249474 XM_005249418 XP_005249475 XM_005249419 XP_005249476 XM_005249420 XP_005249477 XM_005272895 XP_005272952 XM_005272896 XP_005272953 XM_005272897 XP_005272954 XM_005272898 XP_005272955 XM_005272899 XP_005272956 XM_005272900 XP_005272957 XM_005272901 XP_005272958 XM_005275050 XP_005275107 XM_005275051 XP_005275108 XM_005275052 XP_005275109 XM_005275053 XP_005275110 XM_005275054 XP_005275111 XM_005275055 XP_005275112 XM_005275056 XP_005275113 XM_005275185 XP_005275242 XM_005275186 XP_005275243 XM_005275187 XP_005275244 XM_005275188 XP_005275245 XM_005275189 XP_005275246 XM_005275190 XP_005275247 XM_005275191 XP_005275248 XM_005275307 XP_005275364 XM_005275308 XP_005275365 XM_005275309 XP_005275366 XM_005275310 XP_005275367 XM_005275311 XP_005275368 XM_005275312 XP_005275369 XM_005275313 XP_005275370 XM_005275480 XP_005275537 XM_005275481 XP_005275538 XM_005275482 XP_005275539 XM_005275483 XP_005275540 XM_005275484 XP_005275541 XM_005275485 XP_005275542 XM_005275486 XP_005275543 XM_005275611 XP_005275668 XM_005275612 XP_005275669 XM_005275613 XP_005275670 XM_005275614 XP_005275671 XM_005275615 XP_005275672 XM_005275616 XP_005275673 XM_005275617 XP_005275674 XM_011514918 XP_011513220 XM_011547316 XP_011545618 XM_011547718 XP_011546020 XM_011547935 XP_011546237 XM_011548104 XP_011546406 XM_011548303 XP_011546605 XM_011548488 XP_011546790 XR_241917 XR_241918 XR_241919 XR_241920 XR_246968 XR_246969 XR_246970 XR_246971 XR_247355 XR_247356 XR_247357 XR_247358 XR_247376 XR_247377 XR_247378 XR_247379 XR_247391 XR_247392 XR_247393 XR_247394 XR_247407 XR_247408 XR_247409 XR_247410 XR_247428 XR_247429 XR_247430 XR_247431 XR_926309 XR_926310 XR_926311 XR_926312 XR_952215 XR_952216 XR_952217 XR_952218 XR_952667 XR_952668 XR_952669 XR_952670 XR_952859 XR_952860 XR_952862 XR_952863 XR_952950 XR_952951 XR_952952 XR_952953 XR_953011 XR_953012 XR_953013 XR_953014 XR_953084 XR_953085 XR_953086 XR_953087 NM_001190724 NR_033821 NR_033823 NM_001031722 NP_001026892 NM_001254952 NP_001241881 NM_024909 NP_079185
|
| Function |
Specifically acetylates 'Lys-40' in alpha-tubulin on the lumenal side of microtubules. Required for normal sperm flagellar function. Promotes microtubule destabilization and accelerates microtubule dynamics; this activity may be independent of acetylation activity. Promotes directional cell locomotion and chemotaxis, through AP2A2-dependent acetylation of alpha-tubulin at clathrin-coated pits that are concentrated at the leading edge of migrating cells. May facilitate primary cilium assembly. {ECO:0000255|HAMAP-Rule:MF_03130, ECO:0000269|PubMed:20829795, ECO:0000269|PubMed:21068373, ECO:0000269|PubMed:24097348}.
|
| Subcellular Location |
Cytoplasm {ECO:0000255|HAMAP-Rule:MF_03130, ECO:0000269|PubMed:24097348}. Membrane, clathrin-coated pit {ECO:0000255|HAMAP-Rule:MF_03130, ECO:0000269|PubMed:24097348}. Cell junction, focal adhesion {ECO:0000255|HAMAP-Rule:MF_03130, ECO:0000269|PubMed:24097348}. Cell projection, axon {ECO:0000255|HAMAP-Rule:MF_03130}. Cytoplasm, cytoskeleton {ECO:0000255|HAMAP-Rule:MF_03130}. Cytoplasm, cytoskeleton, spindle {ECO:0000255|HAMAP-Rule:MF_03130}.
|