| Gene Symbol |
PLEKHH2
|
| Entrez Gene |
130271
|
| Alt Symbol |
PLEKHH1L
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
pleckstrin homology domain containing, family H (with MyTH4 domain) member 2
|
| Other Description |
pleckstrin homology domain-containing family H member 2
|
| Swissprots |
Q8N3Q3 Q5JPJ6 Q8IVE3 Q6P4Q1
|
| Accessions |
Q8IVE3 AB095948 BAC23124 AK124381 AK126308 AL832207 CAI46132 AL833400 CAD38637 AL833473 AL833546 AM392539 CAL37417 BC031914 BC063310 AAH63310 XM_011532539 XP_011530841 XR_244924 XR_426981 XR_939656 XR_939657 NM_172069 NP_742066
|
| Function |
In the kidney glomerulus may play a role in linking podocyte foot processes to the glomerular basement membrane. May be involved in stabilization of F-actin by attenuating its depolymerization. Can recruit TGFB1I1 from focal adhesions to podocyte lamellipodia.
|
| Subcellular Location |
Cytoplasm {ECO:0000269|PubMed:22832517}. Cytoplasm, cytoskeleton {ECO:0000269|PubMed:22832517}. Cell membrane {ECO:0000269|PubMed:22832517}; Peripheral membrane protein {ECO:0000269|PubMed:22832517}; Cytoplasmic side {ECO:0000269|PubMed:22832517}. Cell projection, lamellipodium {ECO:0000269|PubMed:22832517}. Note=Localizes to foot process of podocytes. Localization to peripheral regions of lamellipodia seems to be dependent on PI3K.
|
| Tissue Specificity |
Kidney. Reduced expression in patients with focal segmental glomerulosclerosis. {ECO:0000269|PubMed:22832517}.
|