| Gene Symbol |
KCNJ4
|
| Entrez Gene |
3761
|
| Alt Symbol |
HIR, HIRK2, HRK1, IRK-3, IRK3, Kir2.3
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
potassium channel, inwardly rectifying subfamily J, member 4
|
| Other Description |
hippocampal inward rectifier potassium channel|inward rectifier K(+) channel Kir2.3|inward rectifier K+ channel Kir2.3|inward rectifier potassium channel 4|potassium channel, inwardly rectifying subfamily J member 4|potassium inwardly-rectifying channel, subfamily J, member 4
|
| Swissprots |
P48050 Q14D44
|
| Accessions |
EAW60235 EAW60236 P48050 BC032562 AAH32562 BC039618 BC113506 AAI13507 BC113508 AAI13509 BM475496 CR456507 CAG30393 CU013106 CAK54537 CU013394 CAK54836 S72503 AAC60632 U07364 AAA19962 U24056 AAA66076 NM_004981 NP_004972 NM_152868 NP_690607
|
| Function |
Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium. Can be blocked by extracellular barium and cesium (By similarity). {ECO:0000250}.
|
| Subcellular Location |
Cell membrane; Multi-pass membrane protein. Cell junction, synapse, postsynaptic cell membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}. Cytoplasmic vesicle membrane {ECO:0000250}. Note=TAX1BP3 binding promotes dissociation of KCNJ4 from LIN7 famaly members and KCNJ4 internalization. {ECO:0000250}.
|
| Tissue Specificity |
Heart, skeletal muscle, and several different brain regions including the hippocampus.
|
| Top Pathways |
Oxytocin signaling pathway
|
![Western Blot: KIR2.3 Overexpression Lysate (Adult Normal) [NBL1-12171] Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for KIR2.3.](http://www.bioprodhub.com/system/product_images/cel_products/5/sub_2/8789_KIR2.3%2520Overexpression%2520Lysate%2520(Adult%2520Normal)-Western%2520Blot-NBL1-12171-img0002.jpg)