EIF3E

Gene Symbol	EIF3E
Entrez Gene	3646
Alt Symbol	EIF3-P48, EIF3S6, INT6, eIF3-p46
Species	Human
Gene Type	protein-coding
Description	eukaryotic translation initiation factor 3, subunit E
Other Description	eIF-3 p48|eukaryotic translation initiation factor 3 subunit 6|eukaryotic translation initiation factor 3 subunit E|eukaryotic translation initiation factor 3, subunit 6 (48kD)|eukaryotic translation initiation factor 3, subunit 6 48kDa|mammary tumor-associated protein INT6|murine mammary tumor integration site 6 (oncogene homolog)|viral integration site protein INT-6 homolog
Swissprots	P60228 Q8WVK4 Q6FG33 Q64058 O43902 Q64252 Q64059
Accessions	AAC51917 EAW91918 EAW91919 P60228 AK124178 BAG54018 AK310902 AK313186 BAG36003 BC000734 AAH00734 BC005944 BC008419 AAH08419 BC016706 AAH16706 BC017887 AAH17887 BC021679 AAH21679 BG498300 CR457029 CAG33310 CR542275 CAG47071 DQ892278 ABM83204 DQ895478 ABM86404 U54562 AAC51760 U62962 AAB58251 U85947 AAB88873 U94175 AAC51919 NM_001568 NP_001559
Function	Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis. The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S preinitiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation. Required for nonsense- mediated mRNA decay (NMD); may act in conjunction with UPF2 to divert mRNAs from translation to the NMD pathway. May interact with MCM7 and EPAS1 and regulate the proteasome-mediated degradation of these proteins. {ECO:0000255|HAMAP-Rule:MF_03004, ECO:0000269|PubMed:17310990, ECO:0000269|PubMed:17324924, ECO:0000269|PubMe
Subcellular Location	Cytoplasm. Nucleus, PML body.
Tissue Specificity	Ubiquitously expressed. Expressed at highest levels in appendix, lymph, pancreas, skeletal muscle, spleen and thymus. {ECO:0000269|PubMed:8688078, ECO:0000269|PubMed:9295280}.
Top Pathways	RNA transport, Hepatitis C

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Int-6 (D-8) - sc-376899 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Mouse Clonality Monoclonal

Int-6 (A-11) - sc-133251 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Mouse Clonality Monoclonal

Int-6 (H-6) - sc-376109 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Mouse Clonality Monoclonal

Int-6 (H-5) - sc-376110 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Mouse Clonality Monoclonal

Int-6 (A-8) - sc-74505 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Mouse Clonality Monoclonal

Int-6 (G-7) - sc-376821 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Mouse Clonality Monoclonal

Int-6 (K-20) - sc-31746 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Goat Clonality Polyclonal

Int-6 (A-1) - sc-74506 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Mouse Clonality Monoclonal

Int-6 (H-200) - sc-28859 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Rabbit Clonality Polyclonal

Int-6 (C-20) - sc-16370 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Goat Clonality Polyclonal

Anti-eIF3e antibody - ab154397 from Abcam Prices $370.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

Anti-eIF3e antibody [EPR6877] - ab125033 from Abcam Prices $313.00 Sizes 100 µl Host Rabbit Clonality Monoclonal Clone EPR6877

Anti-eIF3e antibody [EPR6878(2)] - ab134958 from Abcam Prices $313.00 Sizes 100 µl Host Rabbit Clonality Monoclonal Clone EPR6878(2)

Anti-eIF3e antibody - C-terminal - ab194335 from Abcam Prices $370.00 Sizes 50 µl Host Mouse Clonality Polyclonal

Anti-EIF3E Antibody - LS-C170819 from LifeSpan Bioscience Prices $365.00 Sizes 100 µg Host Rabbit Clonality Polyclonal

Anti-EIF3E Antibody (aa360-409) - LS-C102294 from LifeSpan Bioscience Prices $365.00 Sizes 50 µg Host Rabbit Clonality Polyclonal

Anti-EIF3E Antibody (aa247-276, APC) - LS-C213731 from LifeSpan Bioscience Prices $545.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-EIF3E Antibody (aa247-276, AP) - LS-C213732 from LifeSpan Bioscience Prices $545.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-EIF3E Antibody (aa247-276, Biotin) - LS-C213733 from LifeSpan Bioscience Prices $545.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-EIF3E Antibody (aa247-276, FITC) - LS-C213734 from LifeSpan Bioscience Prices $545.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-EIF3E Antibody (aa247-276, PE) - LS-C213735 from LifeSpan Bioscience Prices $545.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-EIF3E Antibody (aa247-276, Azide-free, HRP) - LS-C213736 from LifeSpan Bioscience Prices $545.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-EIF3E Antibody (aa1-50) - LS-C289693 from LifeSpan Bioscience Prices $375.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

Anti-EIF3E Antibody (aa247-276) - LS-C321065 from LifeSpan Bioscience Prices $345.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-EIF3E Antibody (Internal, clone EPR6877) - LS-C138968 from LifeSpan Bioscience Prices $395.00 Sizes 100 µl Host Rabbit Clonality Monoclonal Clone EPR6877

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