EIF3E

Gene Symbol	EIF3E
Entrez Gene	3646
Alt Symbol	EIF3-P48, EIF3S6, INT6, eIF3-p46
Species	Human
Gene Type	protein-coding
Description	eukaryotic translation initiation factor 3, subunit E
Other Description	eIF-3 p48|eukaryotic translation initiation factor 3 subunit 6|eukaryotic translation initiation factor 3 subunit E|eukaryotic translation initiation factor 3, subunit 6 (48kD)|eukaryotic translation initiation factor 3, subunit 6 48kDa|mammary tumor-associated protein INT6|murine mammary tumor integration site 6 (oncogene homolog)|viral integration site protein INT-6 homolog
Swissprots	P60228 Q8WVK4 Q6FG33 Q64058 O43902 Q64252 Q64059
Accessions	AAC51917 EAW91918 EAW91919 P60228 AK124178 BAG54018 AK310902 AK313186 BAG36003 BC000734 AAH00734 BC005944 BC008419 AAH08419 BC016706 AAH16706 BC017887 AAH17887 BC021679 AAH21679 BG498300 CR457029 CAG33310 CR542275 CAG47071 DQ892278 ABM83204 DQ895478 ABM86404 U54562 AAC51760 U62962 AAB58251 U85947 AAB88873 U94175 AAC51919 NM_001568 NP_001559
Function	Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis. The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S preinitiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation. Required for nonsense- mediated mRNA decay (NMD); may act in conjunction with UPF2 to divert mRNAs from translation to the NMD pathway. May interact with MCM7 and EPAS1 and regulate the proteasome-mediated degradation of these proteins. {ECO:0000255|HAMAP-Rule:MF_03004, ECO:0000269|PubMed:17310990, ECO:0000269|PubMed:17324924, ECO:0000269|PubMe
Subcellular Location	Cytoplasm. Nucleus, PML body.
Tissue Specificity	Ubiquitously expressed. Expressed at highest levels in appendix, lymph, pancreas, skeletal muscle, spleen and thymus. {ECO:0000269|PubMed:8688078, ECO:0000269|PubMed:9295280}.
Top Pathways	RNA transport, Hepatitis C

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human EIF3E Gene cDNA Clone - orb142999 from Biorbyt Prices $255.00 Sizes 10 μg Species Human

Human-EIF3E-cDNA-Clone - DC04341 from Abgent, a WuXi AppTec company Prices $600.75 Sizes 10 µg Species Human Accession BC000734

EIF3E cDNA (ANA11542) - ANA11542 from Aviva Systems Biology Prices $189.00 Sizes 1 µg Accession NM_001568.2

EIF3E - MBS1270656 from MyBioSource Prices $175.00 Sizes 10ug plasmid + 200ul glycerol stock Species Human Accession BC005944

EIF3E - MBS1272484 from MyBioSource Prices $175.00 Sizes 10ug plasmid + 200ul glycerol stock Species Human Accession BC000734

EIF3E - MBS1273769 from MyBioSource Prices $175.00 Sizes 10ug plasmid + 200ul glycerol stock Species Human Accession BC016706

EIF3E - MBS1272009 from MyBioSource Prices $175.00 Sizes 10ug plasmid + 200ul glycerol stock Species Human Accession BC008419

Human EIF3E cDNA clone(NM_001568.2) - CDFH005783 from Creative Biomart Species Human Accession NM_001568.2

Human EIF3E ORF Clone(NM_001568.2) - CDCR281091 from Creative Biomart Species Human Accession NM_001568.2

Human EIF3E ORF Clone(NM_001568.2) - CDCR281092 from Creative Biomart Species Human Accession NM_001568.2

Human EIF3E ORF Clone(NM_001568.2) - CDCR281093 from Creative Biomart Species Human Accession NM_001568.2

Human EIF3E ORF Clone(NM_001568.2) - CDCL162133 from Creative Biomart Species Human Accession NM_001568.2

Human EIF3E ORF Clone(NM_001568.2) - CDCL162134 from Creative Biomart Species Human Accession NM_001568.2

Human EIF3E Gene ORF cDNA clone in cloning vector - HG14066-G from Sino Biological Species Human

Human EIF3E Gene ORF cDNA clone expression plasmid, C-HA tag - HG14066-CY from Sino Biological Species Human

Human EIF3E Gene ORF cDNA clone expression plasmid, C-GFPSpark tag - HG14066-ACG from Sino Biological Species Human

Human EIF3E Gene ORF cDNA clone expression plasmid, N-His tag - HG14066-NH from Sino Biological Species Human

Human EIF3E Gene ORF cDNA clone expression plasmid, N-Flag tag - HG14066-NF from Sino Biological Species Human

Human EIF3E Gene ORF cDNA clone expression plasmid, N-Myc tag - HG14066-NM from Sino Biological Species Human

Human EIF3E Gene ORF cDNA clone expression plasmid, C-Flag tag - HG14066-CF from Sino Biological Species Human

Human EIF3E Gene ORF cDNA clone expression plasmid, C-His tag - HG14066-CH from Sino Biological Species Human

Human EIF3E Gene ORF cDNA clone expression plasmid, C-Myc tag - HG14066-CM from Sino Biological Species Human

Human EIF3E Gene ORF cDNA clone expression plasmid, N-HA tag - HG14066-NY from Sino Biological Species Human

Human EIF3E Gene ORF cDNA clone expression plasmid, N-GFPSpark tag - HG14066-ANG from Sino Biological Species Human

Human EIF3E Gene ORF cDNA clone expression plasmid, C-OFPSpark tag - HG14066-ACR from Sino Biological Species Human

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