| Gene Symbol | GRM2 |
|---|---|
| Entrez Gene | 2912 |
| Alt Symbol | GLUR2, GPRC1B, MGLUR2, mGlu2 |
| Species | Human |
| Gene Type | protein-coding |
| Description | glutamate receptor, metabotropic 2 |
| Other Description | glutamate metabotropic receptor 2|glutamate receptor homolog|metabotropic glutamate receptor 2 |
| Swissprots | Q52MC6 Q14CU5 Q9H3N6 B0M0K7 Q14416 |
| Accessions | BAB19817 EAW65150 Q14416 AB209164 BAD92401 AK289984 BAF82673 AK302671 BAG63904 AK313056 AK315816 BAF98707 AY999299 AAY14640 BC041447 AAH41447 BC113615 AAI13616 BC113619 AAI13620 BX648951 DA391442 EU432122 ABY87921 HQ258674 ADR83425 L35318 AAA76855 XM_011533635 XP_011531937 XM_011533636 XP_011531938 XM_011533637 XP_011531939 XM_011533638 XP_011531940 XM_011533639 XP_011531941 XM_011533640 XP_011531942 XM_011533641 XP_011531943 XM_011533642 XP_011531944 XM_011533643 XP_011531945 XM_011533644 XP_011531946 XM_011533645 XP_011531947 XM_011533646 XP_011531948 XM_011533647 XP_011531949 XR_940421 NM_000839 NP_000830 NM_001130063 NP_001123535 |
| Function | G-protein coupled receptor for glutamate. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Signaling inhibits adenylate cyclase activity. May mediate suppression of neurotransmission or may be involved in synaptogenesis or synaptic stabilization. {ECO:0000269|PubMed:18297054, ECO:0000269|PubMed:22300836, ECO:0000269|PubMed:23129762, ECO:0000269|PubMed:7620613}. |
| Subcellular Location | Cell membrane; Multi-pass membrane protein. Cell junction, synapse {ECO:0000250}. Cell projection, dendrite {ECO:0000250}. |
| Tissue Specificity | Detected in brain cortex (at protein level). Widely expressed in different regions of the adult brain as well as in fetal brain. {ECO:0000269|PubMed:18297054}. |
| Top Pathways | Glutamatergic synapse, Cocaine addiction, Neuroactive ligand-receptor interaction |