GRM2

Gene Symbol GRM2
Entrez Gene 2912
Alt Symbol GLUR2, GPRC1B, MGLUR2, mGlu2
Species Human
Gene Type protein-coding
Description glutamate receptor, metabotropic 2
Other Description glutamate metabotropic receptor 2|glutamate receptor homolog|metabotropic glutamate receptor 2
Swissprots Q52MC6 Q14CU5 Q9H3N6 B0M0K7 Q14416
Accessions BAB19817 EAW65150 Q14416 AB209164 BAD92401 AK289984 BAF82673 AK302671 BAG63904 AK313056 AK315816 BAF98707 AY999299 AAY14640 BC041447 AAH41447 BC113615 AAI13616 BC113619 AAI13620 BX648951 DA391442 EU432122 ABY87921 HQ258674 ADR83425 L35318 AAA76855 XM_011533635 XP_011531937 XM_011533636 XP_011531938 XM_011533637 XP_011531939 XM_011533638 XP_011531940 XM_011533639 XP_011531941 XM_011533640 XP_011531942 XM_011533641 XP_011531943 XM_011533642 XP_011531944 XM_011533643 XP_011531945 XM_011533644 XP_011531946 XM_011533645 XP_011531947 XM_011533646 XP_011531948 XM_011533647 XP_011531949 XR_940421 NM_000839 NP_000830 NM_001130063 NP_001123535
Function G-protein coupled receptor for glutamate. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Signaling inhibits adenylate cyclase activity. May mediate suppression of neurotransmission or may be involved in synaptogenesis or synaptic stabilization. {ECO:0000269|PubMed:18297054, ECO:0000269|PubMed:22300836, ECO:0000269|PubMed:23129762, ECO:0000269|PubMed:7620613}.
Subcellular Location Cell membrane; Multi-pass membrane protein. Cell junction, synapse {ECO:0000250}. Cell projection, dendrite {ECO:0000250}.
Tissue Specificity Detected in brain cortex (at protein level). Widely expressed in different regions of the adult brain as well as in fetal brain. {ECO:0000269|PubMed:18297054}.
Top Pathways Glutamatergic synapse, Cocaine addiction, Neuroactive ligand-receptor interaction

mGluR-2 CRISPR/Cas9 KO Plasmid (h) - sc-403054 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

mGluR-2 HDR Plasmid (h) - sc-403054-HDR from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

mGluR-2 Double Nickase Plasmid (h) - sc-403054-NIC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

mGluR-2 Double Nickase Plasmid (h2) - sc-403054-NIC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

mGluR-2 CRISPR Activation Plasmid (h) - sc-403054-ACT from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

mGluR-2 CRISPR Activation Plasmid (h2) - sc-403054-ACT-2 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

mGluR-2 Lentiviral Activation Particles (h) - sc-403054-LAC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

mGluR-2 Lentiviral Activation Particles (h2) - sc-403054-LAC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

mGluR-2 siRNA (h) - sc-61028 from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

mGluR-2 shRNA Plasmid (h) - sc-61028-SH from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

mGluR-2 shRNA (h) Lentiviral Particles - sc-61028-V from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

mGluR2 RNAi - H00002912-R02 from Novus Biologicals

Category siRNA
Prices $399.00
Sizes 20 nmol
Species Reactivities Human

CompoZr® Knockout ZFN Kit - CKOZFN9702 from Sigma-Aldrich

Category ZFN Kit
Prices $4,999.00
Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND9702 from Sigma-Aldrich

Category ZFN Kit
Prices $3,999.00
Sizes 1 kt

MISSION® 3′UTR Lenti GoClone™ - HUTR12199 from Sigma-Aldrich

Category miRNA
Prices $350.00
Sizes hutr12199

GRM2 siRNA (Human) - CRH1965 from Cohesion Biosciences

Category siRNA
Prices $340.00, $510.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

GRM2 - MBS8215183 from MyBioSource

Prices $365.00, $515.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

Human GRM2 siRNA - orb262467 from Biorbyt

Category siRNA
Prices $485.00, $629.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

GRM2 shRNA Plasmid (Human) - CHH1965 from Cohesion Biosciences

Category siRNA
Prices $500.00, $750.00
Sizes 150 µg, 300 µg
Species Reactivities Human
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