PRKAG2

Gene Symbol PRKAG2
Entrez Gene 51422
Alt Symbol AAKG, AAKG2, CMH6, H91620p, WPWS
Species Human
Gene Type protein-coding
Description protein kinase, AMP-activated, gamma 2 non-catalytic subunit
Other Description 5'-AMP-activated protein kinase subunit gamma-2|AMPK subunit gamma-2|hypothetical protein
Swissprots Q53Y07 Q9NUZ9 Q6NUI0 Q9ULX8 Q75MP4 Q9UDN8 Q9UGJ0
Accessions AAF03528 AAS02032 EAL24516 EAW53983 EAW53984 Q9UGJ0 AB025580 BAA84695 AF087875 AAK00413 AI084919 AJ249976 CAB65116 AK001887 BAA91962 AK074675 BAC11129 AK092716 AK301123 BAH13414 AK307798 AK308116 AK314646 AW664063 BC020540 AAH20540 BC068598 AAH68598 BM988346 BT007127 AAP35791 CR933725 CAI46256 DA084454 DA123009 DA151645 DA187928 DA697901 DC379218 HQ447509 ADQ31995 XM_005250002 XP_005250059 XM_005250004 XP_005250061 XM_005250006 XP_005250063 XM_006716021 XP_006716084 XM_011516282 XP_011514584 XM_011516283 XP_011514585 XM_011516284 XP_011514586 XM_011516285 XP_011514587 XM_011516286 XP_011514588 XM_011516287 XP_011514589 NM_001040633 NP_001035723 NM_001304527 NP_001291456 NM_001304531 NP_001291460 NM_016203 NP_057287 NM_024429 NP_077747
Function AMP/ATP-binding subunit of AMP-activated protein kinase (AMPK), an energy sensor protein kinase that plays a key role in regulating cellular energy metabolism. In response to reduction of intracellular ATP levels, AMPK activates energy-producing pathways and inhibits energy-consuming processes: inhibits protein, carbohydrate and lipid biosynthesis, as well as cell growth and proliferation. AMPK acts via direct phosphorylation of metabolic enzymes, and by longer-term effects via phosphorylation of transcription regulators. Also acts as a regulator of cellular polarity by remodeling the actin cytoskeleton; probably by indirectly activating myosin. Gamma non-catalytic subunit mediates binding to AMP, ADP and ATP, leading to activate or inhibit AMPK: AMP-binding results in allosteric activation of alpha catalytic subunit (PRKAA1 or PRKAA2) both by inducing phosphorylation and preventing dephosphorylation of catalytic subunits. ADP also stimulates phosphorylation, without stimulating alread
Tissue Specificity Isoform B is ubiquitously expressed except in liver and thymus. The highest level is detected in heart with abundant expression in placenta and testis.
Top Pathways Non-alcoholic fatty liver disease (NAFLD), Glucagon signaling pathway, AMPK signaling pathway, Oxytocin signaling pathway, Circadian rhythm

AMPKγ2 Antibody - 2536 from Cell Signaling Technology

Prices $99.00, $246.00
Sizes 20 µl (2 western blots), 100 µl (10 western blots)
Host Rabbit
Clonality Polyclonal
Western blot analysis of extracts from 293 (human), NBT-II (rat), and Neuro-2A (mouse) cells, using AMPKγ2 Antibody.

AMPKγ2 (F-2) - sc-398804 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
AMPKγ2 (F-2): sc-398804. Western blot analysis of AMPKγ2 expression in non-transfected: sc-117752 (A) and mouse AMPKγ2 transfected: sc-118382 (B) whole cell lysates.

AMPKγ2 (H-260) - sc-20165 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
AMPKγ2 (H-260): sc-20165. Immunoperoxidase staining of formalin fixed, paraffin-embedded human heart muscle tissue showing cytoplasmic staining of myocytes.

AMPKγ2 (N-20) - sc-19141 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
AMPKγ2 (N-20): sc-19141. Western blot analysis of AMPKγ2 expression in non-transfected: sc-117752 (A) and mouse AMPKγ2 transfected: sc-118382 (B) 293T whole cell lysates.

Anti-PRKAG2 antibody - ab196730 from Abcam

Prices $370.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
All lanes : Anti-PRKAG2 antibody (ab196730) at 1/500 dilutionLane 1 : K562 cell extractLane 2 : K562 cell extract with immunizing peptide

Anti-PRKAG2 antibody - ab169170 from Abcam

Prices $370.00
Sizes 50 µg
Host Mouse
Clonality Polyclonal
All lanes : Anti-PRKAG2 antibody (ab169170) at 1 µg/mlLane 1 : PRKAG2 transfected 293T cell lysate (36.08 KDa)Lane 2 : Non-transfected 293T cell lysateLysates/proteins at 15 µl per lane.SecondaryGoat anti-mouse HRP at 1/2500 dilution

Anti-PRKAG2 antibody - ab169149 from Abcam

Prices $370.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
All lanes : Anti-PRKAG2 antibody (ab169149) at 1 µgLane 1 : PRKAG2-transfected 293T cell lysateLane 2 : Non-transfected 293T cell lysateLysates/proteins at 15 µl per lane.SecondaryGoat Anti-Mouse IgG developed using the ECL technique

Anti-PRKAG2 / AMPK Gamma 2 Antibody (N-Terminus) - LS-C3638 from LifeSpan Bioscience

Prices $495.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-PRKAG2 / AMPK Gamma 2 Antibody (C-Terminus) - LS-C203267 from LifeSpan Bioscience

Prices $245.00
Sizes 40 µg
Host Rabbit
Clonality Polyclonal

Anti-PRKAG2 / AMPK Gamma 2 Antibody (phospho-Ser60) - LS-C20506 from LifeSpan Bioscience

Prices $405.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Anti-PRKAG2 / AMPK Gamma 2 Antibody (aa290-508, Biotin) - LS-C301080 from LifeSpan Bioscience

Prices $435.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-PRKAG2 / AMPK Gamma 2 Antibody (aa290-508, FITC) - LS-C303769 from LifeSpan Bioscience

Prices $465.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-PRKAG2 / AMPK Gamma 2 Antibody (aa290-508) - LS-C296124 from LifeSpan Bioscience

Prices $415.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Western blot of recombinant PRKAG2 / AMPK Gamma 2.

Anti-PRKAG2 / AMPK Gamma 2 Antibody (aa1-50) - LS-C119303 from LifeSpan Bioscience

Prices $315.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
IHC of paraffin-embedded human heart tissue, using PRKAG2 Antibody. The picture on the right is treated with the synthesized peptide.

Anti-PRKAG2 / AMPK Gamma 2 Antibody (aa386-569) - LS-C186349 from LifeSpan Bioscience

Prices $335.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
AMPK gamma 2 antibody [C2C3], C-term detects PRKAG2 protein at nucleus and cytosol on hepatoma by immunohistochemical analysis. Sample: Paraffin-embedded hepatoma. AMPK gamma 2 antibody [C2C3], C-term dilution:1:500.

Anti-PRKAG2 / AMPK Gamma 2 Antibody (aa192-569) - LS-C186045 from LifeSpan Bioscience

Prices $335.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
AMPK gamma 2 antibody detects PRKAG2 protein at cytosol on gastric carcinoma by immunohistochemical analysis. Sample: Paraffin-embedded gastric carcinoma tissue. AMPK gamma 2 antibody dilution:1:500.

PRKAG2 Antibody - NBP1-89324 from Novus Biologicals

Prices $419.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Western Blot: PRKAG2 Antibody [NBP1-89324] - Western blot analysis in mouse cell line NIH-3T3, rat cell line NBT-II and rat cell line pC12.

PRKAG2 Antibody - NBP1-32697 from Novus Biologicals

Prices $329.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

PRKAG2 Antibody - H00051422-B01 from Novus Biologicals

Prices $359.00
Sizes 50 µl
Host Mouse
Clonality Polyclonal
Western Blot: PRKAG2 Antibody [H00051422-B01] - Analysis of PRKAG2 expression in transfected 293T cell line by PRKAG2 polyclonal antibody. Lane 1: PRKAG2 transfected lysate(36.08 KDa). Lane 2: Non-transfected lysate.

PRKAG2 Antibody - H00051422-B01P from Novus Biologicals

Prices $359.00
Sizes 50 µg
Host Mouse
Clonality Polyclonal
Western Blot: PRKAG2 Antibody [H00051422-B01P] - Analysis of PRKAG2 expression in transfected 293T cell line by PRKAG2 polyclonal antibody.  Lane 1: PRKAG2 transfected lysate(36.08 KDa). Lane 2: Non-transfected lysate.

PRKAG2 Antibody (3C4) - H00051422-M01 from Novus Biologicals

Prices $359.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone 3C4
Western Blot: PRKAG2 Antibody (3C4) [H00051422-M01] - Analysis of PRKAG2 expression in transfected 293T cell line by PRKAG2 monoclonal antibody (M01), clone 3C4.Lane 1: PRKAG2 transfected lysate (Predicted MW: 37.5 KDa).Lane 2: Non-transfected lysate.

PRKAG2 Antibody - H00051422-D01P from Novus Biologicals

Prices $399.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Western Blot: PRKAG2 Antibody [H00051422-D01P] - Analysis of PRKAG2 expression in human stomach.

Anti-PRKAG2 antibody produced in mouse - SAB1407488 from Sigma-Aldrich

Prices $347.00
Sizes 50 µg
Host Mouse
Clonality Polyclonal
<B>Immunofluorescence</B><BR/>Anti-PRKAG2: <B>Cat. No. SAB1407488</B>: Antibody concentration: 10 μg/mL using HeLa cell.

Monoclonal Anti-PRKAG2 antibody produced in mouse - WH0051422M1 from Sigma-Aldrich

Prices $347.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone 3C4
<B>Sandwich ELISA</B><BR/>Monoclonal Anti-PRKAG2, <B>Cat. No. WH0051422M1</B>: the detection limit for recombinant GST tagged PRKAG2 is approximately 0.03ng/mL.

Anti-PRKAG2 antibody produced in rabbit - SAB1410927 from Sigma-Aldrich

Prices $347.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
<B>Immunoblotting</B><BR/>Anti-PRKAG2: <B>Cat. No. SAB1410927</B>: Antibody concentration: 0.1-5 μg/mL. Specific band of ~37.5 kDa using PRKAG2 transfected 293T lysate.<BR/><B>Lanes</B><BR/>1. Transfected 293T lysate.<BR/>2. Non-transfected 293T lysate.
Search more