| Gene Symbol |
PRKAG2
|
| Entrez Gene |
51422
|
| Alt Symbol |
AAKG, AAKG2, CMH6, H91620p, WPWS
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
protein kinase, AMP-activated, gamma 2 non-catalytic subunit
|
| Other Description |
5'-AMP-activated protein kinase subunit gamma-2|AMPK subunit gamma-2|hypothetical protein
|
| Swissprots |
Q53Y07 Q9NUZ9 Q6NUI0 Q9ULX8 Q75MP4 Q9UDN8 Q9UGJ0
|
| Accessions |
AAF03528 AAS02032 EAL24516 EAW53983 EAW53984 Q9UGJ0 AB025580 BAA84695 AF087875 AAK00413 AI084919 AJ249976 CAB65116 AK001887 BAA91962 AK074675 BAC11129 AK092716 AK301123 BAH13414 AK307798 AK308116 AK314646 AW664063 BC020540 AAH20540 BC068598 AAH68598 BM988346 BT007127 AAP35791 CR933725 CAI46256 DA084454 DA123009 DA151645 DA187928 DA697901 DC379218 HQ447509 ADQ31995 XM_005250002 XP_005250059 XM_005250004 XP_005250061 XM_005250006 XP_005250063 XM_006716021 XP_006716084 XM_011516282 XP_011514584 XM_011516283 XP_011514585 XM_011516284 XP_011514586 XM_011516285 XP_011514587 XM_011516286 XP_011514588 XM_011516287 XP_011514589 NM_001040633 NP_001035723 NM_001304527 NP_001291456 NM_001304531 NP_001291460 NM_016203 NP_057287 NM_024429 NP_077747
|
| Function |
AMP/ATP-binding subunit of AMP-activated protein kinase (AMPK), an energy sensor protein kinase that plays a key role in regulating cellular energy metabolism. In response to reduction of intracellular ATP levels, AMPK activates energy-producing pathways and inhibits energy-consuming processes: inhibits protein, carbohydrate and lipid biosynthesis, as well as cell growth and proliferation. AMPK acts via direct phosphorylation of metabolic enzymes, and by longer-term effects via phosphorylation of transcription regulators. Also acts as a regulator of cellular polarity by remodeling the actin cytoskeleton; probably by indirectly activating myosin. Gamma non-catalytic subunit mediates binding to AMP, ADP and ATP, leading to activate or inhibit AMPK: AMP-binding results in allosteric activation of alpha catalytic subunit (PRKAA1 or PRKAA2) both by inducing phosphorylation and preventing dephosphorylation of catalytic subunits. ADP also stimulates phosphorylation, without stimulating alread
|
| Tissue Specificity |
Isoform B is ubiquitously expressed except in liver and thymus. The highest level is detected in heart with abundant expression in placenta and testis.
|
| Top Pathways |
Non-alcoholic fatty liver disease (NAFLD), Glucagon signaling pathway, AMPK signaling pathway, Oxytocin signaling pathway, Circadian rhythm
|