Gene Symbol | PTBP3 |
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Entrez Gene | 9991 |
Alt Symbol | ROD1 |
Species | Human |
Gene Type | protein-coding |
Description | polypyrimidine tract binding protein 3 |
Other Description | ROD1 regulator of differentiation 1|fission yeast differentiation regulator|polypyrimidine tract-binding protein 3|regulator of differentiation 1 |
Swissprots | B1ALY6 Q68DB9 B1ALY5 B1ALY2 B3KME7 Q86YB3 Q86YH9 O95758 B1ALY3 |
Accessions | EAW59099 EAW59100 EAW59101 EAW59102 O95758 AB023967 BAA75466 AK001685 BAG50959 AK302558 BAG63824 AL710523 BC039896 AAH39896 BC044585 AAH44585 BC045825 BI463123 BQ006891 BX097575 BX422279 CN371677 CR749471 CAH18301 XM_005252324 XP_005252381 XM_006717343 XP_006717406 XM_006717346 XP_006717409 XM_011519265 XP_011517567 XM_011519266 XP_011517568 XM_011519267 XP_011517569 NM_001163788 NP_001157260 NM_001163790 NP_001157262 NM_001244896 NP_001231825 NM_001244897 NP_001231826 NM_001244898 NP_001231827 NM_005156 NP_005147 |
Function | RNA-binding protein that mediates pre-mRNA alternative splicing regulation. Plays a role in the regulation of cell proliferation, differentiation and migration. Positive regulator of EPO-dependent erythropoiesis. Participates in cell differentiation regulation by repressing tissue-specific exons. Promotes FAS exon 6 skipping. Binds RNA, preferentially to both poly(G) and poly(U). {ECO:0000269|PubMed:10207106, ECO:0000269|PubMed:18335065, ECO:0000269|PubMed:19441079, ECO:0000269|PubMed:20937273}. |
Tissue Specificity | Expressed in several hematopoietic cell lines examined. {ECO:0000269|PubMed:10207106}. |
ROD1 CRISPR/Cas9 KO Plasmid (h) - sc-417557 from Santa Cruz Biotechnology
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ROD1 HDR Plasmid (h) - sc-417557-HDR from Santa Cruz Biotechnology
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ROD1 Double Nickase Plasmid (h) - sc-417557-NIC from Santa Cruz Biotechnology
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ROD1 Double Nickase Plasmid (h2) - sc-417557-NIC-2 from Santa Cruz Biotechnology
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ROD1 CRISPR Activation Plasmid (h) - sc-417557-ACT from Santa Cruz Biotechnology
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ROD1 CRISPR Activation Plasmid (h2) - sc-417557-ACT-2 from Santa Cruz Biotechnology
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ROD1 Lentiviral Activation Particles (h) - sc-417557-LAC from Santa Cruz Biotechnology
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ROD1 Lentiviral Activation Particles (h2) - sc-417557-LAC-2 from Santa Cruz Biotechnology
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ROD1 siRNA (h) - sc-106897 from Santa Cruz Biotechnology
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ROD1 shRNA Plasmid (h) - sc-106897-SH from Santa Cruz Biotechnology
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ROD1 shRNA (h) Lentiviral Particles - sc-106897-V from Santa Cruz Biotechnology
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ROD1 RNAi - H00009991-R01 from Novus Biologicals
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MISSION® esiRNA - EHU071961 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN18499 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND18499 from Sigma-Aldrich
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PTBP3 siRNA (Human) - CRH6723 from Cohesion Biosciences
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shRNA set against Human ROD1 (NM_005156.6) - SHH397648 from Creative biogene
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Human PTBP3 siRNA - orb267225 from Biorbyt
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PTBP3 shRNA Plasmid (Human) - CHH6723 from Cohesion Biosciences
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