| Gene Symbol | SUPT6H |
|---|---|
| Entrez Gene | 6830 |
| Alt Symbol | SPT6, SPT6H, emb-5 |
| Species | Human |
| Gene Type | protein-coding |
| Description | suppressor of Ty 6 homolog (S. cerevisiae) |
| Other Description | hSPT6|histone chaperone suppressor of Ty6|tat-CT2 protein|tat-cotransactivator 2 protein|transcription elongation factor SPT6 |
| Swissprots | Q9BTI2 Q7LDK4 Q9BTH9 Q96AH3 Q6GMQ4 A7E2B4 Q8N526 Q92775 Q7KZ85 Q15737 Q7KYW9 |
| Accessions | CBX47552 CCQ43205 EAW51116 EAW51117 EAW51118 EAW51119 Q7KZ85 AF070532 AAC28631 AK126585 AL833607 BC003692 AAH03692 BC003696 AAH03696 BC017105 AAH17105 BC033074 AAH33074 BC073963 AAH73963 BC136522 AAI36523 BC136524 AAI36525 BC150268 AAI50269 D79984 BAA11479 U38623 AAC99996 U38658 AAB18949 XM_005258027 XP_005258084 XM_011525147 XP_011523449 XM_011525148 XP_011523450 XM_011525149 XP_011523451 XM_011525150 XP_011523452 XM_011525151 XP_011523453 XM_011525152 XP_011523454 NM_003170 NP_003161 |
| Function | Transcription elongation factor which binds histone H3 and plays a key role in the regulation of transcription elongation and mRNA processing. Enhances the transcription elongation by RNA polymerase II (RNAPII) and is also required for the efficient activation of transcriptional elongation by the HIV-1 nuclear transcriptional activator, Tat. Besides chaperoning histones in transcription, acts to transport and splice mRNA by forming a complex with IWS1 and the C-terminal domain (CTD) of the RNAPII subunit RPB1 (POLR2A). The SUPT6H:IWS1:CTD complex recruits mRNA export factors (ALYREF/THOC4, EXOSC10) as well as histone modifying enzymes (such as SETD2), to ensure proper mRNA splicing, efficient mRNA export and elongation-coupled H3K36 methylation, a signature chromatin mark of active transcription. SUPT6H via its association with SETD1A, regulates both class-switch recombination and somatic hypermutation through formation of H3K4me3 epigenetic marks on activation-induced cytidine deamina |
| Subcellular Location | Nucleus {ECO:0000305}. |
| Tissue Specificity | Ubiquitously expressed. |
SPT6 CRISPR/Cas9 KO Plasmid (h) - sc-406219 from Santa Cruz Biotechnology
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SPT6 HDR Plasmid (h) - sc-406219-HDR from Santa Cruz Biotechnology
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SPT6 Double Nickase Plasmid (h) - sc-406219-NIC from Santa Cruz Biotechnology
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SPT6 Double Nickase Plasmid (h2) - sc-406219-NIC-2 from Santa Cruz Biotechnology
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SPT6 CRISPR Activation Plasmid (h) - sc-406219-ACT from Santa Cruz Biotechnology
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SPT6 CRISPR Activation Plasmid (h2) - sc-406219-ACT-2 from Santa Cruz Biotechnology
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SPT6 Lentiviral Activation Particles (h) - sc-406219-LAC from Santa Cruz Biotechnology
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SPT6 Lentiviral Activation Particles (h2) - sc-406219-LAC-2 from Santa Cruz Biotechnology
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SPT6 siRNA (h) - sc-93909 from Santa Cruz Biotechnology
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SPT6 shRNA Plasmid (h) - sc-93909-SH from Santa Cruz Biotechnology
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SPT6 shRNA (h) Lentiviral Particles - sc-93909-V from Santa Cruz Biotechnology
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Spt6 RNAi - H00006830-R01 from Novus Biologicals
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MISSION® esiRNA - EHU156821 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN20845 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND20845 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR04569 from Sigma-Aldrich
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SUPT6H siRNA (Human) - CRH4669 from Cohesion Biosciences
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SUPT6H - MBS8204083 from MyBioSource
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shRNA set against Human SUPT6H(NM_003170.3) - SHH222522 from Creative biogene
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Human SUPT6H siRNA - orb265171 from Biorbyt
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SUPT6H shRNA Plasmid (Human) - CHH4669 from Cohesion Biosciences
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SUPT6H miRNA 3'UTR clone - MiUTR1H-10071 from Creative biogene
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