SUPT6H

Gene Symbol SUPT6H
Entrez Gene 6830
Alt Symbol SPT6, SPT6H, emb-5
Species Human
Gene Type protein-coding
Description suppressor of Ty 6 homolog (S. cerevisiae)
Other Description hSPT6|histone chaperone suppressor of Ty6|tat-CT2 protein|tat-cotransactivator 2 protein|transcription elongation factor SPT6
Swissprots Q9BTI2 Q7LDK4 Q9BTH9 Q96AH3 Q6GMQ4 A7E2B4 Q8N526 Q92775 Q7KZ85 Q15737 Q7KYW9
Accessions CBX47552 CCQ43205 EAW51116 EAW51117 EAW51118 EAW51119 Q7KZ85 AF070532 AAC28631 AK126585 AL833607 BC003692 AAH03692 BC003696 AAH03696 BC017105 AAH17105 BC033074 AAH33074 BC073963 AAH73963 BC136522 AAI36523 BC136524 AAI36525 BC150268 AAI50269 D79984 BAA11479 U38623 AAC99996 U38658 AAB18949 XM_005258027 XP_005258084 XM_011525147 XP_011523449 XM_011525148 XP_011523450 XM_011525149 XP_011523451 XM_011525150 XP_011523452 XM_011525151 XP_011523453 XM_011525152 XP_011523454 NM_003170 NP_003161
Function Transcription elongation factor which binds histone H3 and plays a key role in the regulation of transcription elongation and mRNA processing. Enhances the transcription elongation by RNA polymerase II (RNAPII) and is also required for the efficient activation of transcriptional elongation by the HIV-1 nuclear transcriptional activator, Tat. Besides chaperoning histones in transcription, acts to transport and splice mRNA by forming a complex with IWS1 and the C-terminal domain (CTD) of the RNAPII subunit RPB1 (POLR2A). The SUPT6H:IWS1:CTD complex recruits mRNA export factors (ALYREF/THOC4, EXOSC10) as well as histone modifying enzymes (such as SETD2), to ensure proper mRNA splicing, efficient mRNA export and elongation-coupled H3K36 methylation, a signature chromatin mark of active transcription. SUPT6H via its association with SETD1A, regulates both class-switch recombination and somatic hypermutation through formation of H3K4me3 epigenetic marks on activation-induced cytidine deamina
Subcellular Location Nucleus {ECO:0000305}.
Tissue Specificity Ubiquitously expressed.

SPT6 (E-4) - sc-393920 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
SPT6 (E-4): sc-393920. Western blot analysis of SPT6 expression in Jurkat whole cell lysate (A) and HeLa nuclear extract (B).

SPT6 (C-6) - sc-393938 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
SPT6 (C-6): sc-393938. Western blot analysis of SPT6 expression in Jurkat (A) and Hep G2 (B) whole cell lysates and HeLa nuclear extract (C).

SPT6 (C-16) - sc-109433 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

SPT6 (H-227) - sc-367017 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
SPT6 (H-227): sc-367017. Western blot analysis of SPT6 expression in A-431 whole cell lysate (A) and Jurkat (B) and HeLa (C) nuclear extracts.

SPT6 (E-12) - sc-109434 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

SPT6 (L-22) - sc-134032 from Santa Cruz Biotechnology

Prices $279.00
Sizes 100 µg/ml
Host Rabbit
Clonality Polyclonal
SPT6 (L-22): sc-134032. Western blot analysis of SPT6 expression in Jurkat whole cell lysate.

Anti-Spt6 antibody - ab32820 from Abcam

Prices $380.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Lane 1 : MarkerLanes 2 - 4 : Anti-Spt6 antibody (ab32820) at 1/500 dilutionLane 5 : High Mark markerLane 1 : As aboveLane 2 : HeLa (Human epithelial carcinoma cell line) Whole Cell Lysate at 10 µgLane 3 : Jurkat (Human T cell lymphoblast-like cell line) Whole Cell Lysate (ab7899) at 20 µgLane 4 : HeLa (Human epithelial carcinoma cell line) Nuclear Lysate at 20 µgLane 5 : As aboveSecondaryLanes 2 - 4 : IR Dye 680 Conjugated Goat anti Rabbit IgG (H+L) at 1/21250 dilutionPerformed under reducing conditions.

Anti-Spt6 antibody - ab49066 from Abcam

Prices $370.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Lane 1 : Lane 2 : Anti-Spt6 antibody (ab49066) at 2.5 µg/mlLane 1 : MARKERLane 2 : Jurkat cell lysate at 10 µgSecondaryLane 2 : HRP conjugated anti-Rabbit IgG at 1/50000 dilution

Anti-Spt6 antibody - ab129632 from Abcam

Prices $370.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
Anti-Spt6 antibody (ab129632) at 1/100 dilution + 293 cell line lysates at 35 µg

Anti-SUPT6H / SPT6 Antibody (aa1050-1100) - LS-C91858 from LifeSpan Bioscience

Prices $545.00
Sizes 20 µg
Host Rabbit
Clonality Polyclonal

Anti-SUPT6H / SPT6 Antibody (C-Terminus) - LS-C91859 from LifeSpan Bioscience

Prices $545.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-SUPT6H / SPT6 Antibody (aa98-127, AP) - LS-C270739 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-SUPT6H / SPT6 Antibody (aa98-127, APC) - LS-C270740 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-SUPT6H / SPT6 Antibody (N-Terminus) - LS-C31490 from LifeSpan Bioscience

Prices $325.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
A: Marker, B: Jurkat Cell Lysate

Anti-SUPT6H / SPT6 Antibody (aa98-127, Biotin) - LS-C270741 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-SUPT6H / SPT6 Antibody (aa98-127, FITC) - LS-C270742 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-SUPT6H / SPT6 Antibody (aa98-127, Azide-free, HRP) - LS-C270743 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-SUPT6H / SPT6 Antibody (aa98-127, PE) - LS-C270744 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-SUPT6H / SPT6 Antibody (aa98-127) - LS-C325503 from LifeSpan Bioscience

Prices $345.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-SUPT6H / SPT6 Antibody (C-Terminus) - LS-C287659 from LifeSpan Bioscience

Prices $375.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Anti-SUPT6H / SPT6 Antibody (aa71-120) - LS-C109784 from LifeSpan Bioscience

Prices $365.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
SUPT6H antibody LS-C109784 Western blot of Jurkat lysate.

Anti-SUPT6H / SPT6 Antibody (N-Terminus) - LS-C201276 from LifeSpan Bioscience

Prices $365.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Western blot of Human Lung Tumor. SUPT6H antibody dilution 1.0 ug/ml.

Anti-SUPT6H / SPT6 Antibody (aa1660-1709) - LS-C205693 from LifeSpan Bioscience

Prices $365.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
SUPT6H / SPT6 antibody Western Blot of Colorectal Tumor. Antibody dilution: 1 ug/ml.

Anti-SUPT6H / SPT6 Antibody (aa98-127) - LS-C161621 from LifeSpan Bioscience

Prices $295.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
SUPT6H Antibody western blot of 293 cell line lysates (35 ug/lane). The SUPT6H antibody detected the SUPT6H protein (arrow).

Anti-SUPT6H / SPT6 Antibody (aa1050-1100) - LS-C287660 from LifeSpan Bioscience

Prices $375.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Detection of Human and Mouse SUPT6H by Immunohistochemistry. Sample: FFPE sections of human breast carcinoma (left) and mouse squamous cell carcinoma (right). Antibody: Affinity purified rabbit anti-SUPT6H used at a dilution of 1:200 (1 ug/ml). Detection: DAB.
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