Gene Symbol | RNF170 |
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Entrez Gene | 81790 |
Alt Symbol | ADSA, SNAX1 |
Species | Human |
Gene Type | protein-coding |
Description | ring finger protein 170 |
Other Description | E3 ubiquitin-protein ligase RNF170|putative LAG1-interacting protein |
Swissprots | Q8N5G9 Q8N2B5 E9PIL4 Q86YC0 Q8IXR7 Q9H0V6 D3DSY6 Q96K19 Q8NG30 Q7Z483 |
Accessions | CAI93421 EAW63201 EAW63202 EAW63203 EAW63204 Q96K19 AA973979 AF209504 AAM92891 AK027748 BAB55340 AK090864 BAC03534 AK095625 AK225086 AK225568 AL136620 CAB66555 BC013422 AAH13422 BC032393 AAH32393 BC039461 AAH39461 BC044566 AAH44566 BC058289 BG910500 DA751961 DQ586731 EU832307 ACE87564 EU832391 ACE86876 XM_006716404 XP_006716467 XM_006716405 XP_006716468 XM_006716406 XP_006716469 XM_006716407 XP_006716470 XM_011544666 XP_011542968 XR_949487 NM_001160223 NP_001153695 NM_001160224 NP_001153696 NM_001160225 NP_001153697 NM_030954 NP_112216 NR_027668 NR_027669 |
Function | E3 ubiquitin-protein ligase that plays an essential role in stimulus-induced inositol 1,4,5-trisphosphate receptor type 1 (ITPR1) ubiquitination and degradation via the endoplasmic reticulum-associated degradation (ERAD) pathway. Also involved in ITPR1 turnover in resting cells. {ECO:0000269|PubMed:21610068}. |
Subcellular Location | Endoplasmic reticulum membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}. |
Tissue Specificity | Expressed in the spinal chord. {ECO:0000269|PubMed:21115467}. |
RNF170 CRISPR/Cas9 KO Plasmid (h) - sc-410169 from Santa Cruz Biotechnology
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RNF170 HDR Plasmid (h) - sc-410169-HDR from Santa Cruz Biotechnology
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RNF170 Double Nickase Plasmid (h) - sc-410169-NIC from Santa Cruz Biotechnology
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RNF170 Double Nickase Plasmid (h2) - sc-410169-NIC-2 from Santa Cruz Biotechnology
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RNF170 CRISPR Activation Plasmid (h) - sc-410169-ACT from Santa Cruz Biotechnology
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RNF170 CRISPR Activation Plasmid (h2) - sc-410169-ACT-2 from Santa Cruz Biotechnology
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RNF170 Lentiviral Activation Particles (h) - sc-410169-LAC from Santa Cruz Biotechnology
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RNF170 Lentiviral Activation Particles (h2) - sc-410169-LAC-2 from Santa Cruz Biotechnology
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RNF170 siRNA (h) - sc-77659 from Santa Cruz Biotechnology
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RNF170 shRNA Plasmid (h) - sc-77659-SH from Santa Cruz Biotechnology
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RNF170 shRNA (h) Lentiviral Particles - sc-77659-V from Santa Cruz Biotechnology
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RNF170 RNAi - H00081790-R01 from Novus Biologicals
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MISSION® esiRNA - EHU075761 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN18403 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND18403 from Sigma-Aldrich
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RNF170 siRNA (Human) - CRJ3050 from Cohesion Biosciences
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RNF170 - MBS8204903 from MyBioSource
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shRNA set against Human RNF170 (NM_030954.3) - SHH396960 from Creative biogene
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Human RNF170 siRNA - orb273551 from Biorbyt
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RNF170 shRNA Plasmid (Human) - CHJ3050 from Cohesion Biosciences
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RNF170 miRNA 3'UTR clone - MiUTR3H-13341 from Creative biogene
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RNF170 miRNA 3'UTR clone - MiUTR4H-TG07595 from Creative biogene
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