| Gene Symbol | Pdxp |
|---|---|
| Entrez Gene | 57028 |
| Alt Symbol | 1600027H05Rik, AB041662, PLPP |
| Species | Mouse |
| Gene Type | protein-coding |
| Description | pyridoxal (pyridoxine, vitamin B6) phosphatase |
| Other Description | PLP phosphatase|PLP-phosophatase|chronophilin|chronophin|pyridoxal phosphate phosphatase |
| Swissprots | P60487 |
| Accessions | P60487 AB041662 BAA95107 AI845716 AI852697 AK043228 AK212826 AY366300 AAR12209 BC037010 AAH37010 BC046955 BC049107 BC058388 AAH58388 BC069982 AAH69982 BU148105 BY060098 CX236940 NM_020271 NP_064667 |
| Function | Protein serine phosphatase that dephosphorylates 'Ser-3' in cofilin and probably also dephosphorylates phospho-serine residues in DSTN. Regulates cofilin-dependent actin cytoskeleton reorganization. Required for normal progress through mitosis and normal cytokinesis (By similarity). Does not dephosphorylate phospho-threonines in LIMK1. Does not dephosphorylate peptides containing phospho-tyrosine. Pyridoxal phosphate phosphatase. Has some activity towards pyridoxal 5'-phosphate (PLP), pyridoxine 5'- phosphate (PMP) and pyridoxine 5'-phosphate (PNP), with a highest activity with PLP followed by PNP. {ECO:0000250, ECO:0000269|PubMed:24338687, ECO:0000269|Ref.4}. |
| Subcellular Location | Cytoplasm, cytosol {ECO:0000250}. Cytoplasm, cytoskeleton {ECO:0000250}. Cell projection, ruffle membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}; Cytoplasmic side {ECO:0000250}. Cell projection, lamellipodium membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}; Cytoplasmic side {ECO:0000250}. Cell membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}; Cytoplasmic side {ECO:0000250}. Note=Colocalizes with the actin cytoskeleton in membrane ruffles and lamellipodia. Diffusely distributed throughout the cytosol during pro-metaphase and metaphase. Detected at the dynamic cell poles during telophase. Detected at the cleavage furrow and contractile ring during cytokinesis. Transiently detected at the plasma membrane in late stages of cytokinesis. Detected at the midbody (By similarity). {ECO:0000250}. |
| Tissue Specificity | Ubiquitous. highly expressed in brain (at protein level). {ECO:0000269|Ref.4}. |
| Top Pathways | Vitamin B6 metabolism |
pyridoxal phosphatase CRISPR/Cas9 KO Plasmid (m) - sc-425336 from Santa Cruz Biotechnology
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pyridoxal phosphatase HDR Plasmid (m) - sc-425336-HDR from Santa Cruz Biotechnology
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pyridoxal phosphatase Double Nickase Plasmid (m) - sc-425336-NIC from Santa Cruz Biotechnology
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pyridoxal phosphatase Double Nickase Plasmid (m2) - sc-425336-NIC-2 from Santa Cruz Biotechnology
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pyridoxal phosphatase CRISPR Activation Plasmid (m) - sc-425336-ACT from Santa Cruz Biotechnology
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pyridoxal phosphatase CRISPR Activation Plasmid (m2) - sc-425336-ACT-2 from Santa Cruz Biotechnology
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pyridoxal phosphatase Lentiviral Activation Particles (m) - sc-425336-LAC from Santa Cruz Biotechnology
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pyridoxal phosphatase Lentiviral Activation Particles (m2) - sc-425336-LAC-2 from Santa Cruz Biotechnology
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pyridoxal phosphatase siRNA (m) - sc-61426 from Santa Cruz Biotechnology
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pyridoxal phosphatase shRNA Plasmid (m) - sc-61426-SH from Santa Cruz Biotechnology
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pyridoxal phosphatase shRNA (m) Lentiviral Particles - sc-61426-V from Santa Cruz Biotechnology
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MISSION® esiRNA - EMU095461 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN38516 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND38516 from Sigma-Aldrich
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PDXP siRNA (Mouse) - CRM5962 from Cohesion Biosciences
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shRNA set against Mouse PDXP (NM_020271.3) - SHH373156 from Creative biogene
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shRNA set against Mouse Pdxp(NM_020271.3) - SHR103362 from Creative biogene
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Mouse PDXP siRNA - orb285438 from Biorbyt
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PDXP shRNA Plasmid (Mouse) - CHM5962 from Cohesion Biosciences
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PDXP miRNA 3'UTR clone - MiUTR1M-09084 from Creative biogene
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