| Gene Symbol |
EP300
|
| Entrez Gene |
2033
|
| Alt Symbol |
KAT3B, RSTS2, p300
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
E1A binding protein p300
|
| Other Description |
E1A-associated protein p300|E1A-binding protein, 300kD|histone acetyltransferase p300|p300 HAT
|
| Swissprots |
Q09472 B1AKC2
|
| Accessions |
ABB16440 CAM82745 EAW60408 Q09472 AA235167 AB385004 BAG10860 AI302618 BC053889 AAH53889 BC172280 AAI72280 BQ428177 BQ921059 BQ930911 CA393789 CB132795 CB155618 CF130065 CN278277 CN278282 D53020 DB047746 N57495 U01877 AAA18639 XM_006724165 XP_006724228 NM_001429 NP_001420
|
| Function |
Functions as histone acetyltransferase and regulates transcription via chromatin remodeling. Acetylates all four core histones in nucleosomes. Histone acetylation gives an epigenetic tag for transcriptional activation. Mediates cAMP-gene regulation by binding specifically to phosphorylated CREB protein. Mediates acetylation of histone H3 at 'Lys-122' (H3K122ac), a modification that localizes at the surface of the histone octamer and stimulates transcription, possibly by promoting nucleosome instability. Mediates acetylation of histone H3 at 'Lys-27' (H3K27ac). Also functions as acetyltransferase for nonhistone targets. Acetylates 'Lys-131' of ALX1 and acts as its coactivator in the presence of CREBBP. Acetylates SIRT2 and is proposed to indirectly increase the transcriptional activity of TP53 through acetylation and subsequent attenuation of SIRT2 deacetylase function. Acetylates HDAC1 leading to its inactivation and modulation of transcription. Acts as a TFAP2A-mediated transcriptiona
|
| Subcellular Location |
Cytoplasm. Nucleus. Note=In the presence of ALX1 relocalizes from the cytoplasm to the nucleus. Colocalizes with ROCK2 in the nucleus.
|
| Top Pathways |
Viral carcinogenesis, Glucagon signaling pathway, Epstein-Barr virus infection, MicroRNAs in cancer, cAMP signaling pathway
|