EP300

Gene Symbol EP300
Entrez Gene 2033
Alt Symbol KAT3B, RSTS2, p300
Species Human
Gene Type protein-coding
Description E1A binding protein p300
Other Description E1A-associated protein p300|E1A-binding protein, 300kD|histone acetyltransferase p300|p300 HAT
Swissprots Q09472 B1AKC2
Accessions ABB16440 CAM82745 EAW60408 Q09472 AA235167 AB385004 BAG10860 AI302618 BC053889 AAH53889 BC172280 AAI72280 BQ428177 BQ921059 BQ930911 CA393789 CB132795 CB155618 CF130065 CN278277 CN278282 D53020 DB047746 N57495 U01877 AAA18639 XM_006724165 XP_006724228 NM_001429 NP_001420
Function Functions as histone acetyltransferase and regulates transcription via chromatin remodeling. Acetylates all four core histones in nucleosomes. Histone acetylation gives an epigenetic tag for transcriptional activation. Mediates cAMP-gene regulation by binding specifically to phosphorylated CREB protein. Mediates acetylation of histone H3 at 'Lys-122' (H3K122ac), a modification that localizes at the surface of the histone octamer and stimulates transcription, possibly by promoting nucleosome instability. Mediates acetylation of histone H3 at 'Lys-27' (H3K27ac). Also functions as acetyltransferase for nonhistone targets. Acetylates 'Lys-131' of ALX1 and acts as its coactivator in the presence of CREBBP. Acetylates SIRT2 and is proposed to indirectly increase the transcriptional activity of TP53 through acetylation and subsequent attenuation of SIRT2 deacetylase function. Acetylates HDAC1 leading to its inactivation and modulation of transcription. Acts as a TFAP2A-mediated transcriptiona
Subcellular Location Cytoplasm. Nucleus. Note=In the presence of ALX1 relocalizes from the cytoplasm to the nucleus. Colocalizes with ROCK2 in the nucleus.
Top Pathways Viral carcinogenesis, Glucagon signaling pathway, Epstein-Barr virus infection, MicroRNAs in cancer, cAMP signaling pathway

Human KAT3B / p300 full length protein - ab82235 from Abcam

Category Protein
Source Baculovirus
Species Human

Human KAT3B / p300 protein fragment - ab105913 from Abcam

Category Protein
Source Baculovirus infected sf9 cells
Species Human
SDS-PAGE showing ab105913 at approximately 120kDa.

Human KAT3B / p300 protein fragment - ab198116 from Abcam

Category Protein
Source E. coli
Species Human
4-20% SDS-PAGE analysis of ab198116. Lane 1: 3.6 µg ab198116 Lane 2: Protein marker Stained with Coomassie Blue

Human KAT3B / p300 protein fragment - ab56274 from Abcam

Category Protein
Source Baculovirus infected sf9 cells
Species Human
ab56274 on SDS-PAGE.

Human KAT3B / p300 protein fragment - ab82076 from Abcam

Category Protein
Source E. coli
Species Human

Human KAT3B / p300 protein fragment - ab82234 from Abcam

Category Protein
Source Baculovirus
Species Human

KAT3B / p300 peptide - ab4914 from Abcam

Category Peptide

EP300 / p300 Antibody Blocking Peptide - LS-E7300 from LifeSpan Bioscience

Category Peptide
Prices $145.00
Sizes 100 µg

Recombinant Human KAT3B/p300 Protein - H00002033-Q01 from Novus Biologicals

Category Protein
Prices $369.00, $529.00
Sizes 10 µg, 25 µg
Source Wheat Germ
Species Human

KAT3B/p300 Peptide - P1377 from Novus Biologicals

Category Peptide
Species Human

Phospho-EP300S89-Antibody-Blocking-peptide - BP3197a from Abgent, a WuXi AppTec company

Category Peptide
Prices $120.00
Sizes 100 µg

Biotinylated-P300-S89-Non-phospho-Control-Peptide - SP2042d from Abgent, a WuXi AppTec company

Category Peptide
Prices $150.00
Sizes 1 mg

P300-S89-Non-phospho-Control-Peptide - SP2042c from Abgent, a WuXi AppTec company

Category Peptide
Prices $132.00
Sizes 1 mg

Biotinylated-P300-S89-Phospho-Peptide - SP2042b from Abgent, a WuXi AppTec company

Category Peptide
Prices $300.00
Sizes 1 mg

P300-S89-Phospho-Peptide - SP2042a from Abgent, a WuXi AppTec company

Category Peptide
Prices $150.00
Sizes 1 mg

EP300 peptide - orb218819 from Biorbyt

Category Peptide
Prices $357.00, $723.00
Sizes 1 mg, 5 mg
Species Human, Mouse, Rat

HAT protein - 30R-2412 from Fitzgerald

Category Protein
Prices $335.00
Sizes 100 µg
Source E.coli
Species Human

p300 (phospho-Ser1834) Blocking Peptide - abx064150 from Abbexa

Category Peptide
Species Human, Mouse, Rat

p300 Blocking Peptide - abx062583 from Abbexa

Category Peptide
Species Human, Mouse, Rat, Bovine, Chicken, Dog, Pig

EP300 / P300 - H00002033-Q01-10 from Acris Antibodies

Category Protein
Prices $380.00
Sizes 10 µg
Source in vitro transl.
Species Human

EP300 / P300 - H00002033-Q01-25 from Acris Antibodies

Category Protein
Prices $500.00
Sizes 25 µg
Source in vitro transl.
Species Human

EP300 / P300 Control Peptide - SP5316CP from Acris Antibodies

Category Peptide
Prices $205.00
Sizes 50 µg

Recombinant p300 (1041-1161) protein - 31372 from ActiveMotif

Category Protein
Prices $395.00, $2,600.00
Sizes 100 µg, 1 mg
Source E. coli
Species Human
Recombinant p300 (1041-1161) protein gel. p300 (1041-1161) protein was run on a 10% SDS-PAGE gel and stained with Coomassie blue.

Recombinant p300 protein - 31124 from ActiveMotif

Category Protein
Prices $495.00
Sizes 4 µg
Source Baculovirus
Species Human

Recombinant p300 protein, catalytic domain - 31205 from ActiveMotif

Category Protein
Prices $390.00
Sizes 5 µg
Source Baculovirus
Species Human
Recombinant p300 protein activity assay. p300 activity using the fluorescent HAT assay kit (Catalog No. 56100). p300 was tested on both histone H3 (residues 5-23 of human H3) and H4 peptide (residues 1-19 of human H4) substrates. p300 activity was inhibited by anacardic acid.
Search more